Multicompartment Micelle Morphology Evolution in Degradable Miktoarm Star Terpolymers
Abstract
Multicompartment micelles with segmented wormlike structures consisting of alternating poly(ethylethylene) (PEE) and poly(gamma-methyl-epsilon-caprolactone) (PMCL) layers were formed upon dispersing samples of micro-[PEE][poly(ethylene oxide)][PMCL] (micro-EOC) miktoarm star block terpolymers in neutral water. Subjecting these dispersions to a pH 12 aqueous buffer at 50 degrees C led to the hydrolytic degradation of the PMCL chains. After 4 weeks, the majority of the micro-EOC molecules were degraded into PEE-b-poly(ethylene oxide) (EO) diblocks and PMCL homopolymers. Although the resulting EO diblocks were expected to assemble into simple cylindrical micelles, the actual "daughter micelle" morphologies were much richer. The initial segmented wormlike micelles evolved into raspberry-like vesicle structures composed of spherical PMCL subdomains embedded in a PEE matrix. This dramatic change in the morphology of the multicompartment micelles is due to rearrangement of micro-EOC/EO/PMCL composite micelles to a structure that minimizes unfavorable interfacial interactions between the three mutually immiscible polymers. This type of micelle-to-micelle morphological evolution induced by block degradation in a miktoarm star terpolymer system holds promise for the development of "smart" delivery capabilities.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Time-resolved cryo-TEM can efficiently monitor the kinetics of amphiphilic polymers assembly and disassembly in solution, allowing real-time observation of nanosystems formation and disruption.
“the kinetics of amphiphilic polymers assembly and disassembly in solution can be efficiently monitored using timeresolved cryo-TEM, which allows the real-time observation of nanosystems formation and disruption.”
From Polymeric micelles in drug delivery: An insight of the techniques for their characterization and assessment in biorelevant conditions (2021) · cites this paper as [180]
Saito et al. evaluated the morphological changes of μ-EOC micelles in aqueous buffer at pH 12 and 50°C after 2, 7, 14 and 28 days to determine the impact of alkaline hydrolysis on micelles shape and integrity.
“Saito et al. [181] evaluated the morphological changes of micelles composed of μ-[PEE][poly(ethylene oxide)][PMCL] (μ-EOC) in an aqueous buffer at pH 12 and 50 • C after 2, 7, 14 and 28 days, to determine the impact of alkaline hydrolysis on micelles shape and integrity.”
From Polymeric micelles in drug delivery: An insight of the techniques for their characterization and assessment in biorelevant conditions (2021) · cites this paper as [181]
Cryo-TEM images showed a transition from cylindrical wormlike micelles (water, time zero) to sheet-like structures (pH 12, 2 days) and finally to large spherical assembly (pH 12, 14 days) for μ-EOC micelles.
“Cryo-TEM images showed the transition from cylindrical wormlike micelles (water, time zero), to sheet-like structures (pH 12, 2 days) and finally to large spherical assembly (pH 12, 14 days) allowing the authors to figure out the mechanisms driving micelles transition.”
From Polymeric micelles in drug delivery: An insight of the techniques for their characterization and assessment in biorelevant conditions (2021) · cites this paper as [181]
Cites
Pluronic® block copolymers as novel polymer therapeutics for drug and gene delivery
Kabanov, A. V., Batrakova, E. V., & Alakhov, V. Y. (2002) · Journal of Controlled Release · doi:10.1016/s0168-3659(02)00009-3 · Cited by 1,474 · see citing works
Multicompartment Micelles from ABC Miktoarm Stars in Water
Li, Z., Kesselman, E., Talmon, Y., Hillmyer, M. A., & Lodge, T. P. (2004) · Science · doi:10.1126/science.1103350 · Cited by 947 · see citing works
Self-citationCurrent status of polymeric gene delivery systems☆
Park, T. G., JEONG, J., & KIM, S. (2006) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2006.03.007 · Cited by 945 · see citing works
Toward ‘smart’ nano-objects by self-assembly of block copolymers in solution
Rodríguez‐Hernández, J., Chécot, F., Gnanou, Y., & Lecommandoux, S. (2005) · Progress in Polymer Science · doi:10.1016/j.progpolymsci.2005.04.002 · Cited by 795 · see citing works
Controlled environment vitrification system: An improved sample preparation technique
Bellare, J., DAVIS, H. T., Scriven, L. E., & Talmon, Y. (1988) · Journal of Electron Microscopy Technique · doi:10.1002/jemt.1060100111 · Cited by 614 · see citing works
Multi-Stimuli Sensitive Amphiphilic Block Copolymer Assemblies
Klaikherd, A., Nagamani, C., & Thayumanavan, S. (2009) · Journal of the American Chemical Society · doi:10.1021/ja809475a · Cited by 594 · see citing works
Stimuli-responsive polymer vesicles
Li, M., & Keller, P. (2009) · Soft Matter · doi:10.1039/b815725a · Cited by 466 · see citing works
Synthetic Micelle Sensitive to IR Light via a Two-Photon Process
Goodwin, A. P., Mynar, J. L., Ma, Y., Fleming, G. R., & Fréchet, J. M. J. (2005) · Journal of the American Chemical Society · doi:10.1021/ja0523035 · Cited by 352 · see citing works
Kubowicz, S., Baussard, J., Lutz, J., Thünemann, A. F., von Berlepsch, H., & Laschewsky, A. (2005) · Angewandte Chemie International Edition · doi:10.1002/anie.200500584 · Cited by 299 · see citing works
Liggins, R. T., & Burt, H. M. (2002) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(02)00016-9 · Cited by 286 · see citing works
Morphologies of Multicompartment Micelles Formed by ABC Miktoarm Star Terpolymers
Li, Z., Hillmyer, M. A., & Lodge, T. P. (2006) · Langmuir · doi:10.1021/la0620051 · Cited by 270 · see citing works
Self-citationHydrolytic Degradation of Poly(ethylene oxide)-block-Polycaprolactone Worm Micelles
Geng, Y., & Discher, D. E. (2005) · Journal of the American Chemical Society · doi:10.1021/ja053902e · Cited by 269 · see citing works
Simultaneous, Segregated Storage of Two Agents in a Multicompartment Micelle
Lodge, T. P., Rasdal, A., Li, Z., & Hillmyer, M. A. (2005) · Journal of the American Chemical Society · doi:10.1021/ja056841t · Cited by 257 · see citing works
Self-citationLaterally Nanostructured Vesicles, Polygonal Bilayer Sheets, and Segmented Wormlike Micelles
Li, Z., Hillmyer, M. A., & Lodge, T. P. (2006) · Nano Letters · doi:10.1021/nl0608700 · Cited by 198 · see citing works
Self-citationLi, Z., Hillmyer, M. A., & Lodge, T. P. (2005) · Macromolecules · doi:10.1021/ma052199b · Cited by 176 · see citing works
Self-citationZhou, Z., Li, Z., Ren, Y. J., Hillmyer, M. A., & Lodge, T. P. (2003) · Journal of the American Chemical Society · doi:10.1021/ja036551h · Cited by 176 · see citing works
Self-citationEnzymatically Triggered Self-Assembly of Block Copolymers
Amir, R. J., Zhong, S., Pochan, D. J., & Hawker, C. J. (2009) · Journal of the American Chemical Society · doi:10.1021/ja9060917 · Cited by 158 · see citing works
Multicompartment Micelles: Has the Long‐Standing Dream Become a Reality?
Lutz, J., & Laschewsky, A. (2005) · Macromolecular Chemistry and Physics · doi:10.1002/macp.200500067 · Cited by 152 · see citing works
Polymerized micelles with compartments
Laschewsky, A. (2003) · Current Opinion in Colloid & Interface Science · doi:10.1016/s1359-0294(03)00049-9 · Cited by 150 · see citing works
Multicompartment Micelles from Polyester-Containing ABC Miktoarm Star Terpolymers
Saito, N., Liu, C., Lodge, T. P., & Hillmyer, M. A. (2008) · Macromolecules · doi:10.1021/ma801001s · Cited by 131 · see citing works
Self-citationFang, B., Walther, A., Wolf, A. M., Xu, Y., Yuan, J., & Müller, A. H. E. (2009) · Angewandte Chemie International Edition · doi:10.1002/anie.200806051 · Cited by 123 · see citing works
von Berlepsch, H., Böttcher, C., Skrabania, K., & Laschewsky, A. (2009) · Chemical Communications · doi:10.1039/b903658j · Cited by 105 · see citing works
Multicompartment Core Micelles of Triblock Terpolymers in Organic Media
Schacher, F. H., Walther, A., Ruppel, M., Drechsler, M., & Müller, A. H. E. (2009) · Macromolecules · doi:10.1021/ma9002424 · Cited by 104 · see citing works
Aqueous Dispersions of Poly(ethylene oxide)-b-poly(γ-methyl-ε-caprolactone) Block Copolymers
Zupancich, J. A., Bates, F. S., & Hillmyer, M. A. (2006) · Macromolecules · doi:10.1021/ma060642s · Cited by 92 · see citing works
Self-citationSkrabania, K., Laschewsky, A., von Berlepsch, H., & Böttcher, C. (2009) · Langmuir · doi:10.1021/la900253j · Cited by 91 · see citing works
Multicompartment Micelles from pH-Responsive Miktoarm Star Block Terpolymers
Liu, C., Hillmyer, M. A., & Lodge, T. P. (2009) · Langmuir · doi:10.1021/la900845u · Cited by 91 · see citing works
Self-citationSynthesis and Characterization of Triptych μ-ABC Star Triblock Copolymers
Li, Z., Hillmyer, M. A., & Lodge, T. P. (2004) · Macromolecules · doi:10.1021/ma048607d · Cited by 82 · see citing works
Self-citationEvolution of Multicompartment Micelles to Mixed Corona Micelles Using Solvent Mixtures
Liu, C., Hillmyer, M. A., & Lodge, T. P. (2008) · Langmuir · doi:10.1021/la802336k · Cited by 71 · see citing works
Self-citationWalther, A., & Müller, A. H. E. (2009) · Chemical Communications · doi:10.1039/b820507h · Cited by 55 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Ghezzi, M., Pescina, S., Padula, C., Santi, P., Del Favero, E., Cantù, L., & Nicoli, S. (2021) · Journal of Controlled Release · doi:10.1016/j.jconrel.2021.02.031 · Cited by 1,135 · see citing works
Functional Block Copolymers: Nanostructured Materials with Emerging Applications
Schacher, F. H., Rupar, P. A., & Manners, I. (2012) · Angewandte Chemie International Edition · doi:10.1002/anie.201200310 · Cited by 693 · see citing works
Precise hierarchical self-assembly of multicompartment micelles
Gröschel, A. H., Schacher, F. H., Schmalz, H., Borisov, O. V., Zhulina, E. B., Walther, A., & Müller, A. H. E. (2012) · Nature Communications · doi:10.1038/ncomms1707 · Cited by 550 · see citing works
The effects of polymeric nanostructure shape on drug delivery
Venkataraman, S., Hedrick, J. L., Ong, Z. Y., Yang, C. H., Ee, P. L. R., Hammond, P. T., & Yang, Y. Y. (2011) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2011.06.016 · Cited by 509 · see citing works
Multicompartment Block Polymer Micelles
Moughton, A. O., Hillmyer, M. A., & Lodge, T. P. (2011) · Macromolecules · doi:10.1021/ma201865s · Cited by 469 · see citing works
Self-citationSelf-assembly concepts for multicompartment nanostructures
Gröschel, A. H., & Müller, A. H. E. (2015) · Nanoscale · doi:10.1039/c5nr02448j · Cited by 321 · see citing works
Theory of Block Polymer Micelles: Recent Advances and Current Challenges
Zhulina, E. B., & Borisov, O. V. (2012) · Macromolecules · doi:10.1021/ma300195n · Cited by 225 · see citing works
Shi, P., Qu, Y., Liu, C., Khan, H. R., Sun, P., & Zhang, W. (2015) · ACS Macro Letters · doi:10.1021/acsmacrolett.5b00928 · Cited by 116 · see citing works
Self-citationMarsat, J., Heydenreich, M., Kleinpeter, E., von Berlepsch, H., Böttcher, C., & Laschewsky, A. (2011) · Macromolecules · doi:10.1021/ma200032j · Cited by 112 · see citing works
Supramolecular ABC Miktoarm Star Terpolymer Based on Host–Guest Inclusion Complexation
Huan, X., Wang, D., Dong, R., Tu, C., Zhu, B., Yan, D., & Zhu, X. (2012) · Macromolecules · doi:10.1021/ma300693h · Cited by 106 · see citing works
Duong, H. T. T., Marquis, C. P., Whittaker, M. R., Davis, T. P., & Boyer, C. A. (2011) · Macromolecules · doi:10.1021/ma201085z · Cited by 101 · see citing works
Huo, M., Zeng, M., Li, D., Liu, L., Wei, Y., & Yuan, J. (2017) · Macromolecules · doi:10.1021/acs.macromol.7b01629 · Cited by 99 · see citing works
Liu, G., Ma, R., Ren, J., Li, Z., Zhang, H., Zhang, Z., An, Y., & Shi, L. (2012) · Soft Matter · doi:10.1039/c2sm26690c · Cited by 91 · see citing works
Counterion-Mediated Hierarchical Self-Assembly of an ABC Miktoarm Star Terpolymer
Hanisch, A., Gröschel, A. H., Förtsch, M., Drechsler, M., Jinnai, H., Ruhland, T. M., Schacher, F. H., & Müller, A. H. E. (2013) · ACS Nano · doi:10.1021/nn400031u · Cited by 91 · see citing works
Micellar structures of linear triblock terpolymers: Three blocks but many possibilities
Wyman, I., & Liu, G. (2013) · Polymer · doi:10.1016/j.polymer.2012.12.079 · Cited by 89 · see citing works
Polymeric Micelles for Multidrug Delivery and Combination Therapy
Aw, M. S., Kurian, M., & Lošić, D. (2013) · Chemistry - A European Journal · doi:10.1002/chem.201302097 · Cited by 80 · see citing works
Multicompartment Polymer Nanostructures with Ratiometric Dual-Emission pH-Sensitivity
Sun, G., Cui, H., Lin, L. Y., Lee, N. S., Yang, C., Neumann, W. L., Freskos, J. N., Shieh, J. J., Dorshow, R. B., & Wooley, K. L. (2011) · Journal of the American Chemical Society · doi:10.1021/ja200182t · Cited by 80 · see citing works
Betthausen, E., Drechsler, M., Förtsch, M., Schacher, F. H., & Müller, A. H. E. (2011) · Soft Matter · doi:10.1039/c1sm05822c · Cited by 79 · see citing works
Jiang, T., Wang, L., Lin, S., Lin, J., & Li, Y. (2011) · Langmuir · doi:10.1021/la201080z · Cited by 77 · see citing works
Newcomb, C. J., Moyer, T. J., Lee, S. S., & Stupp, S. I. (2012) · Current Opinion in Colloid & Interface Science · doi:10.1016/j.cocis.2012.09.004 · Cited by 76 · see citing works
A Close Look at Molecular Self-Assembly with the Transmission Electron Microscope
Rizvi, A., Mulvey, J. T., Carpenter, B. P., Talosig, A. R., & Patterson, J. P. (2021) · Chemical Reviews · doi:10.1021/acs.chemrev.1c00189 · Cited by 74 · see citing works
Miktoarm Star Polymers: Synthesis and Applications
Liu, M., Blankenship, J. R., Levi, A. E., Fu, Q., Hudson, Z. M., & Bates, C. M. (2022) · Chemistry of Materials · doi:10.1021/acs.chemmater.2c01220 · Cited by 74 · see citing works
Zhu, J., Zhang, S., Zhang, F., Wooley, K. L., & Pochan, D. J. (2012) · Advanced Functional Materials · doi:10.1002/adfm.201202323 · Cited by 72 · see citing works
Multicompartment block copolymer nanoparticles: recent advances and future perspectives
Huang, J., Guo, Y., Gu, S. T., Han, G., Duan, W., Gao, C., & Zhang, W. (2019) · Polymer Chemistry · doi:10.1039/c9py00452a · Cited by 72 · see citing works
Water-Soluble Stimuli Responsive Star-Shaped Segmented Macromolecules
Iatridi, Z., & Tsitsilianis, C. (2011) · Polymers · doi:10.3390/polym3041911 · Cited by 66 · see citing works
Iatridi, Z., & Tsitsilianis, C. (2011) · Chemical Communications · doi:10.1039/c0cc05507g · Cited by 62 · see citing works
Polymers with Star-Related Structures
Hadjichristidis, N., Pitsikalis, M., Iatrou, H., Driva, P., Σακελλαρίου, Γ., & Chatzichristidi, M. (2012) · Elsevier eBooks · doi:10.1016/b978-0-444-53349-4.00161-8 · Cited by 61 · see citing works
Funktionale Blockcopolymere: nanostrukturierte Materialien mit neuen Anwendungsmöglichkeiten
Schacher, F. H., Rupar, P. A., & Manners, I. (2012) · Angewandte Chemie · doi:10.1002/ange.201200310 · Cited by 60 · see citing works
Wang, L., & Lin, J. (2011) · Soft Matter · doi:10.1039/c0sm01079k · Cited by 58 · see citing works
Li, S., He, X. H., Li, Q., Shi, P., & Zhang, W. (2014) · ACS Macro Letters · doi:10.1021/mz500466x · Cited by 53 · see citing works
Solution‐Based Fabrication of Narrow‐Disperse ABC Three‐Segment and Θ‐Shaped Nanoparticles
Zhang, Z., Zhou, C., Dong, H., & Chen, D. (2016) · Angewandte Chemie International Edition · doi:10.1002/anie.201511768 · Cited by 51 · see citing works
Shi, P., Li, Q., He, X. H., Li, S., Sun, P., & Zhang, W. (2014) · Macromolecules · doi:10.1021/ma501598k · Cited by 50 · see citing works
Suo, A., Qian, J., Zhang, Y., Liu, R., Xu, W., & Wang, H. (2016) · Materials Science and Engineering C · doi:10.1016/j.msec.2016.02.007 · Cited by 48 · see citing works
Reversible Light-Triggered Transition of Amphiphilic Random Copolymers
Feng, K., Xie, N., Chen, B., Zhang, L., Tung, C., & Wu, L. (2012) · Macromolecules · doi:10.1021/ma300734z · Cited by 44 · see citing works
Sun, W., He, X., Gao, C., Liao, X., Xie, M., Lin, S., & Yan, D. (2013) · Polymer Chemistry · doi:10.1039/c2py21043f · Cited by 43 · see citing works
Multi-Dimensional Self-Assembly of a Dual-Responsive ABC Miktoarm Star Terpolymer
Xu, F., Wu, D., Huang, Y., Wei, H., Gao, Y., Feng, X., Yan, D., & Mai, Y. (2017) · ACS Macro Letters · doi:10.1021/acsmacrolett.7b00031 · Cited by 43 · see citing works
Core-crosslinked compartmentalized cylinders
Schacher, F. H., Rudolph, T., Drechsler, M., & Müller, A. H. E. (2010) · Nanoscale · doi:10.1039/c0nr00649a · Cited by 41 · see citing works
Mu, C., Fan, X., Tian, W. J., Bai, Y., & Zhou, X. (2012) · Polymer Chemistry · doi:10.1039/c2py20029e · Cited by 40 · see citing works
Chen, Y., Zhang, K., Wang, X., Zhang, F., Zhu, J., Mays, J. W., Wooley, K. L., & Pochan, D. J. (2015) · Macromolecules · doi:10.1021/acs.macromol.5b00752 · Cited by 40 · see citing works
Facile Synthesis of Multicompartment Micelles Based on Biocompatible Poly(3‐hydroxyalkanoate)
Babinot, J., Renard, E., Droumaguet, B. L., Guigner, J., Mura, S., Nicolas, J., Couvreur, P., & Langlois, V. (2012) · Macromolecular Rapid Communications · doi:10.1002/marc.201200692 · Cited by 39 · see citing works
Temperature-Directed Self-Assembly of Multifunctional Polymeric Tadpoles
Bobrin, V. A., & Monteiro, M. J. (2015) · Journal of the American Chemical Society · doi:10.1021/jacs.5b11037 · Cited by 36 · see citing works
Nunns, A., Whittell, G. R., Winnik, M. A., & Ian Manners, A. (2014) · Macromolecules · doi:10.1021/ma501725h · Cited by 36 · see citing works
Kong, W., Jiang, W. J., Zhu, Y., & Li, B. (2012) · Langmuir · doi:10.1021/la3014943 · Cited by 33 · see citing works
pH responsive MWCNT–star terpolymer nanohybrids
Iatridi, Z., & Tsitsilianis, C. (2012) · Soft Matter · doi:10.1039/c2sm27211c · Cited by 33 · see citing works
Synthesis of block polymer miktobrushes
Moughton, A. O., Sagawa, T., Gramlich, W. M., Seo, M., Lodge, T. P., & Hillmyer, M. A. (2012) · Polymer Chemistry · doi:10.1039/c2py20656k · Cited by 32 · see citing works
Self-citationLi, B., Zhao, L., Qian, H., & Lu, Z. (2013) · Soft Matter · doi:10.1039/c3sm52660g · Cited by 30 · see citing works
Influence of Nanostructure Morphology on Host Capacity and Kinetics of Guest Release
Lee, N. S., Lin, L. Y., Neumann, W. L., Freskos, J. N., Karwa, A. S., Shieh, J. J., Dorshow, R. B., & Wooley, K. L. (2011) · Small · doi:10.1002/smll.201100567 · Cited by 28 · see citing works
Polymers with Star‐Related Structures
Hadjichristidis, N., Pitsikalis, M., & Iatrou, H. (2007) · Wiley eBooks · doi:10.1002/9783527631421.ch22 · Cited by 27 · see citing works
Xu, Z., Lü, C., Lindenberger, C., Cao, Y., Wulff, J. E., & Moffitt, M. G. (2017) · ACS Omega · doi:10.1021/acsomega.7b00829 · Cited by 25 · see citing works
Multicompartment Micelles by Aqueous Self-Assembly of μ-A(BC) n Mikto brush Terpolymers
Moughton, A. O., Sagawa, T., Yin, L., Lodge, T. P., & Hillmyer, M. A. (2016) · ACS Omega · doi:10.1021/acsomega.6b00284 · Cited by 24 · see citing works
Self-citationHuo, H., Liu, J., Kannan, S., Chen, L., Zhao, Y., Zhang, L., Chang, G., Zhang, Q., & Liu, F. (2020) · Macromolecules · doi:10.1021/acs.macromol.0c02213 · Cited by 23 · see citing works
Li, S., He, J., Zhang, M., Wang, H., & Ni, P. (2016) · Polymer Chemistry · doi:10.1039/c5py02017d · Cited by 23 · see citing works
Iatridi, Z., Lencina, M. M. S., & Tsitsilianis, C. (2015) · Polymer Chemistry · doi:10.1039/c5py00393h · Cited by 22 · see citing works
Wang, L., Xu, R., Wang, Z., & He, X. (2012) · Soft Matter · doi:10.1039/c2sm26886h · Cited by 22 · see citing works
Novel ABC miktoarm star terpolyphosphoesters: Facile construction and high‐flame retardant property
Qiu, J. X., Zhang, J., Yu, F., Wei, J., & Ding, L. (2015) · Journal of Polymer Science Part A Polymer Chemistry · doi:10.1002/pola.27895 · Cited by 21 · see citing works
Matter, Y., Enea, R., Casse, O., Lee, C., Baryza, J. L., & Meier, W. P. (2011) · Macromolecular Chemistry and Physics · doi:10.1002/macp.201000661 · Cited by 21 · see citing works
Li, C., Liu, H., Tang, D., & Zhao, Y. (2014) · Polymer Chemistry · doi:10.1039/c4py01495b · Cited by 20 · see citing works
Iatridi, Z., Roiter, Y., Stavrouli, N., Minko, S., & Tsitsilianis, C. (2011) · Polymer Chemistry · doi:10.1039/c1py00090j · Cited by 20 · see citing works
Khan, H. R., Chen, S., Zhou, H., Wang, S., & Zhang, W. (2017) · Macromolecules · doi:10.1021/acs.macromol.7b00242 · Cited by 20 · see citing works
Uniform Symmetric and Asymmetric Polymer Nanostructures via Directed Chain Organization
Bobrin, V. A., Chen, S. R., Jia, Z., & Monteiro, M. J. (2018) · Biomacromolecules · doi:10.1021/acs.biomac.8b01558 · Cited by 19 · see citing works
Interfacial behavior of pH responsive ampholytic heteroarm star block terpolymers
Kodiyath, R., Choi, I., Patterson, B. A., Tsitsilianis, C., & Tsukruk, V. V. (2012) · Polymer · doi:10.1016/j.polymer.2012.12.031 · Cited by 18 · see citing works
Bilayer Membrane Permeability of Ionic Liquid-Filled Block Copolymer Vesicles in Aqueous Solution
Bai, Z., Zhao, B., & Lodge, T. P. (2012) · The Journal of Physical Chemistry B · doi:10.1021/jp3033098 · Cited by 17 · see citing works
Self-citationSynthesis and stimulus-responsive micellization of a well-defined H-shaped terpolymer
Mu, C., Fan, X., Tian, W. J., Bai, Y., Yang, Z. C., Fan, W.-W., & Chen, H. (2012) · Polymer Chemistry · doi:10.1039/c2py20586f · Cited by 17 · see citing works
UV-Cross-Linked Polymer Nanostructures with Preserved Asymmetry and Surface Functionality
Chen, S. R., Jia, Z., Bobrin, V. A., & Monteiro, M. J. (2019) · Biomacromolecules · doi:10.1021/acs.biomac.9b01088 · Cited by 16 · see citing works
Coban, D., Gridina, O., Karg, M., & Gröschel, A. H. (2022) · Macromolecules · doi:10.1021/acs.macromol.1c01840 · Cited by 15 · see citing works
Bobrin, V. A., Chen, S. R., Jia, Z., & Monteiro, M. J. (2017) · ACS Macro Letters · doi:10.1021/acsmacrolett.7b00589 · Cited by 15 · see citing works
Multicompartment micelles from A2-star-(B-alt-C) block terpolymers in selective solvents
Huang, C., Liao, C.-H., & Lodge, T. P. (2011) · Soft Matter · doi:10.1039/c1sm05159h · Cited by 14 · see citing works
Self-citationXiao, Y., Lang, S., Zhou, M., Qin, J. Y., Yin, R., Gao, J., Heise, A., & Lang, M. (2016) · Journal of Materials Chemistry B · doi:10.1039/c6tb02507b · Cited by 14 · see citing works
Tuning Solvent Quality Induces Morphological Phase Transitions in Miktoarm Star Polymer Films
Workineh, Z. G., Pellicane, G., & Tsige, M. (2020) · Macromolecules · doi:10.1021/acs.macromol.0c00770 · Cited by 14 · see citing works
Li, S., Xu, Q., Li, K., Wang, Y., Yu, C., & Zhou, Y. (2019) · The Journal of Physical Chemistry B · doi:10.1021/acs.jpcb.9b07685 · Cited by 13 · see citing works
Guo, Y., Ma, Z., Ding, Z., & Li, R. K. Y. (2013) · Langmuir · doi:10.1021/la4023807 · Cited by 11 · see citing works
Chen, S., Chang, X., Sun, P., & Zhang, W. (2017) · Polymer Chemistry · doi:10.1039/c7py01182b · Cited by 11 · see citing works
Conditions for multicompartment polymeric tadpoles via temperature directed self-assembly
Bobrin, V. A., Jia, Z., & Monteiro, M. J. (2017) · Polymer Chemistry · doi:10.1039/c7py01024a · Cited by 10 · see citing works
Synthesis of star–comb‐shaped polymer with porphyrin‐core and its self‐assembly behavior study
Zhang, B., Wang, D., Li, M., Li, Y., & Chen, X. (2012) · Journal of Applied Polymer Science · doi:10.1002/app.36835 · Cited by 9 · see citing works
Solution‐Based Fabrication of Narrow‐Disperse ABC Three‐Segment and Θ‐Shaped Nanoparticles
Zhang, Z., Zhou, C., Dong, H., & Chen, D. (2016) · Angewandte Chemie · doi:10.1002/ange.201511768 · Cited by 9 · see citing works
Bobrin, V. A., Sharma-Brymer, S. E., & Monteiro, M. J. (2025) · ACS Nano · doi:10.1021/acsnano.4c14506 · Cited by 8 · see citing works
Liu, X., Ding, Y., Liu, J., Lin, S., & Zhuang, Q. (2019) · European Polymer Journal · doi:10.1016/j.eurpolymj.2019.04.020 · Cited by 7 · see citing works
Liu, J., Ding, Y., Liu, X., Lin, S., & Zhuang, Q. (2019) · European Polymer Journal · doi:10.1016/j.eurpolymj.2019.06.017 · Cited by 7 · see citing works
Synthesis, self-assembly and pH sensitivity of a novel fluorinated triphilic block copolymer
Li, X., Huo, X. P., Han, H.-J., & Lin, S. (2017) · Chinese Journal of Polymer Science · doi:10.1007/s10118-017-1963-0 · Cited by 6 · see citing works
Wu, J., Wang, Z., Yin, Y., Jiang, R., & Li, B. (2019) · Macromolecules · doi:10.1021/acs.macromol.9b00433 · Cited by 6 · see citing works
Segregation kinetics of miktoarm star polymers: A dissipative particle dynamics study
Gogoi, D., Puri, S., Chauhan, A., & Singh, A. (2024) · Physical review. E · doi:10.1103/physreve.110.034504 · Cited by 5 · see citing works
Kinetically Trapped Block Copolymer Nano‐Objects with Cylinder to Sphere Shape Transition Properties
Li, Y., Peng, B., & Chen, Y. (2014) · Macromolecular Chemistry and Physics · doi:10.1002/macp.201400505 · Cited by 4 · see citing works
Tan, Z., Lan, W., Mao, X., Zhang, L., Luo, X., Xu, J., & Zhu, J. (2021) · Langmuir · doi:10.1021/acs.langmuir.1c02259 · Cited by 3 · see citing works
Nasar, A. S., & Veerapandian, S. (2015) · Macromolecular Chemistry and Physics · doi:10.1002/macp.201500372 · Cited by 3 · see citing works
Jana, S., Byś, K., Štěpánek, M., Pavlová, E., Psurski, M., Mandal, T. K., Appavou, M., & Uchman, M. (2024) · European Polymer Journal · doi:10.1016/j.eurpolymj.2024.113344 · Cited by 2 · see citing works
Ma, Z., Liu, G., Hu, N., Chen, L., & Wei, J. (2024) · RSC Advances · doi:10.1039/d4ra04511d · Cited by 2 · see citing works
Verma, D. K., & Singh, A. (2025) · Soft Matter · doi:10.1039/d5sm00205b · Cited by 2 · see citing works
Hu, D., Yang, H., Liu, J., & Lei, Z. (2016) · Biotechnology and Applied Biochemistry · doi:10.1002/bab.1474 · Cited by 2 · see citing works
Individual Nano-Objects Obtained via Hierarchical Assembly of Polymer Building Blocks
Cauët, S. I., Lee, N. S., Lin, L. Y., & Wooley, K. L. (2012) · Elsevier eBooks · doi:10.1016/b978-0-444-53349-4.00178-3 · Cited by 1 · see citing works
Jiang, X., Zuckermann, R. N., & Balsara, N. P. (2024) · Physical Review Materials · doi:10.1103/physrevmaterials.8.020301 · Cited by 1 · see citing works
Functional mikto-arm star terpolymers by an association-and-reaction strategy
Hu, H., & Liu, G. (2014) · Materials Today Communications · doi:10.1016/j.mtcomm.2014.09.001
Wu, G., Chen, S., & Wang, Y. (2016) · Macromolecular Chemistry and Physics · doi:10.1002/macp.201600283
ABC MIKTOARM STAR TERPOLYMERS AND THEIR SPHERICAL CAPSULES BEARING PH-RESPONSIVE NANOCHANNELS
Hu, H. (2014) · QSpace (Queen's University Library)
Verma, D. K., Singh, A. K., & Singh, A. (2025) · Langmuir · doi:10.1021/acs.langmuir.5c03895
Topology and rigidity controlled coarsening in miktoarm star polymer melts
Gogoi, D., Puri, S., & Singh, A. (2026) · The Journal of Chemical Physics · doi:10.1063/5.0316591
- Authors
- Saito, N., Liu, C., Lodge, T. P., & Hillmyer, M. A.
- Affiliations
- University of Minnesota (US)
- University of Minnesota, Duluth (US)
- Corresponding author
- Lodge, Timothy P.
- Hillmyer, Marc A.
- Venue
- ACS Nano
- Publisher
- American Chemical Society (ACS)
- Published
- 2010-03-10
- Volume
- 4
- Issue
- 4
- Pages
- 1907-1912
- ISSN
- 1936-0851 (ISSN-L)
- 1936-086X
- OpenAlex
- W2080448490
- Cited by
- 95
- References
- 29
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 4 · 2022: 2 · 2021: 3 · 2020: 2 · 2019: 6 · 2018: 1 · 2017: 8 · 2016: 8 · 2015: 7 · 2014: 7 · 2013: 6 · 2012: 21
- FWCI
- 6.66
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- ACS Nano (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Chemistry › Organic Chemistry › Advanced Polymer Synthesis and Characterization
- Physical Sciences › Materials Science › Materials Chemistry › Block Copolymer Self-Assembly
- Physical Sciences › Chemistry › Organic Chemistry › Surfactants and Colloidal Systems
- Keywords
- multicompartment micelles, poly(ethylene oxide), hydrolytic degradation, wormlike micelles, interfacial interactions, drug delivery
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review