Cited by 95Advanced Polymer Synthesis and CharacterizationBlock Copolymer Self-AssemblySurfactants and Colloidal Systems

Multicompartment Micelle Morphology Evolution in Degradable Miktoarm Star Terpolymers

Saito, Naohiko, Liu, Chun, Lodge, Timothy P., Hillmyer, Marc A.·2010·ACS Nano

Abstract

Multicompartment micelles with segmented wormlike structures consisting of alternating poly(ethylethylene) (PEE) and poly(gamma-methyl-epsilon-caprolactone) (PMCL) layers were formed upon dispersing samples of micro-[PEE][poly(ethylene oxide)][PMCL] (micro-EOC) miktoarm star block terpolymers in neutral water. Subjecting these dispersions to a pH 12 aqueous buffer at 50 degrees C led to the hydrolytic degradation of the PMCL chains. After 4 weeks, the majority of the micro-EOC molecules were degraded into PEE-b-poly(ethylene oxide) (EO) diblocks and PMCL homopolymers. Although the resulting EO diblocks were expected to assemble into simple cylindrical micelles, the actual "daughter micelle" morphologies were much richer. The initial segmented wormlike micelles evolved into raspberry-like vesicle structures composed of spherical PMCL subdomains embedded in a PEE matrix. This dramatic change in the morphology of the multicompartment micelles is due to rearrangement of micro-EOC/EO/PMCL composite micelles to a structure that minimizes unfavorable interfacial interactions between the three mutually immiscible polymers. This type of micelle-to-micelle morphological evolution induced by block degradation in a miktoarm star terpolymer system holds promise for the development of "smart" delivery capabilities.

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Crossref · 10.1021/nn9016873

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29 of 29 references verified0 citation errors · 0 not checkable

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  • Time-resolved cryo-TEM can efficiently monitor the kinetics of amphiphilic polymers assembly and disassembly in solution, allowing real-time observation of nanosystems formation and disruption.

    “the kinetics of amphiphilic polymers assembly and disassembly in solution can be efficiently monitored using timeresolved cryo-TEM, which allows the real-time observation of nanosystems formation and disruption.”
  • Saito et al. evaluated the morphological changes of μ-EOC micelles in aqueous buffer at pH 12 and 50°C after 2, 7, 14 and 28 days to determine the impact of alkaline hydrolysis on micelles shape and integrity.

    “Saito et al. [181] evaluated the morphological changes of micelles composed of μ-[PEE][poly(ethylene oxide)][PMCL] (μ-EOC) in an aqueous buffer at pH 12 and 50 • C after 2, 7, 14 and 28 days, to determine the impact of alkaline hydrolysis on micelles shape and integrity.”
  • Cryo-TEM images showed a transition from cylindrical wormlike micelles (water, time zero) to sheet-like structures (pH 12, 2 days) and finally to large spherical assembly (pH 12, 14 days) for μ-EOC micelles.

    “Cryo-TEM images showed the transition from cylindrical wormlike micelles (water, time zero), to sheet-like structures (pH 12, 2 days) and finally to large spherical assembly (pH 12, 14 days) allowing the authors to figure out the mechanisms driving micelles transition.”

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Authors
Saito, N., Liu, C., Lodge, T. P., & Hillmyer, M. A.
Affiliations
  • University of Minnesota (US)
  • University of Minnesota, Duluth (US)
Corresponding author
  • Lodge, Timothy P.
  • Hillmyer, Marc A.
Venue
ACS Nano
Published
2010-03-10
Volume
4
Issue
4
Pages
1907-1912
ISSN
  • 1936-0851 (ISSN-L)
  • 1936-086X
OpenAlex
W2080448490
Cited by
95
References
29
Citations by year
2026: 1 · 2025: 3 · 2024: 4 · 2022: 2 · 2021: 3 · 2020: 2 · 2019: 6 · 2018: 1 · 2017: 8 · 2016: 8 · 2015: 7 · 2014: 7 · 2013: 6 · 2012: 21
FWCI
6.66
Type
journal article
Language
en
Open access
closed
Locations
  • ACS Nano (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Physical Sciences › Chemistry › Organic Chemistry › Advanced Polymer Synthesis and Characterization
  • Physical Sciences › Materials Science › Materials Chemistry › Block Copolymer Self-Assembly
  • Physical Sciences › Chemistry › Organic Chemistry › Surfactants and Colloidal Systems
Keywords
multicompartment micelles, poly(ethylene oxide), hydrolytic degradation, wormlike micelles, interfacial interactions, drug delivery

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