Isolation of Dolastatin 10 from the Marine Cyanobacterium Symploca Species VP642 and Total Stereochemistry and Biological Evaluation of Its Analogue Symplostatin 1

New Colorimetric Cytotoxicity Assay for Anticancer-Drug Screening

Skehan, P., Storeng, R., Scudiero, D. A., Monks, A. P., McMahon, J., Vistica, D. T., Warren, J. T., Bokesch, H. R., Kenney, S., & Boyd, M. R. (1990) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/82.13.1107 · Cited by 9,801 · see citing works

Progress in the chemistry of organic natural products

Habermehl, G. (1983) · Toxicon · doi:10.1016/0041-0101(83)90119-8 · Cited by 541 · see citing works

Isolation of dolastatins 10–15 from the marine mollusc

Pettit, G. R., Kamano, Y., Herald, C. L., Fujii, Y., Kizu, H., Boyd, M. R., Boettner, F. E., Doubek, D. L., Schmidt, J. M., Chapuis, J., et al. (1993) · Tetrahedron · doi:10.1016/0040-4020(93)80003-c · Cited by 159 · see citing works

Synthesis and Antitumor Activity of Novel Dolastatin 10 Analogs.

MIYAZAKI, K., Kobayashi, M., Natsume, T., Gondo, M., Mikami, T., SAKAKIBARA, K., & Tsukagoshi, S. (1995) · Chemical and Pharmaceutical Bulletin · doi:10.1248/cpb.43.1706 · Cited by 111 · see citing works

Cytotoxic Anticancer Drugs: Models and Concepts for Drug Discovery and Development

(1992) · Springer eBooks · doi:10.1007/978-1-4615-3492-1 · Cited by 105 · see citing works

In Vivo Methods for Screening and Preclinical Testing

Corbett, T. H., Valeriote, F. A., LoRusso, P. M., Polin, L., Panchapor, C., Pugh, S., White, K., Knight, J., Demchik, L. L., Jones, J. L., et al. (1997) · Humana Press eBooks · doi:10.1007/978-1-4615-8152-9_5 · Cited by 75 · see citing works

Dolastatin 3 and Two Novel Cyclic Peptides from a Palauan Collection of Lyngbya majuscula

Mitchell, S. S., Faulkner, D. J., Rubins, K., & Bushman, F. D. (2000) · Journal of Natural Products · doi:10.1021/np990353f · Cited by 70 · see citing works

Discovery of Solid Tumor Active Agents Using a Soft-Agar-Colony-Formation Disk-Diffusion-Assay

Corbett, T. H., Valeriote, F. A., Polin, L., Panchapor, C., Pugh, S., White, K., Lowichik, N., Knight, J., Bissery, M.-C., Wozniak, A., et al. (1992) · Springer eBooks · doi:10.1007/978-1-4615-3492-1_3 · Cited by 62 · see citing works

Dolastatin H and Isodolastatin H, Potent Cytotoxic Peptides from the Sea Hare Dolabella auricularia: Isolation, Stereostructures, and Synthesis

Sone, H., Shibata, T., Fujita, T., Ojika, M., & Yamada, K. (1996) · Journal of the American Chemical Society · doi:10.1021/ja9519086 · Cited by 62 · see citing works

Lyngbyastatin 2 and Norlyngbyastatin 2, Analogues of Dolastatin G and Nordolastatin G from the Marine Cyanobacterium Lyngbya majuscula

Luesch, H., Yoshida, W. Y., Moore, R. E., & Paul, V. J. (1999) · Journal of Natural Products · doi:10.1021/np990310z · Cited by 48 · see citing works

Isolation and stereostructure of dolastatin I, a cytotoxic cyclic hexapeptide from the Japanese sea hare Dolabella auricularia

Sone, H., Kigoshi, H., & Yamada, K. (1997) · Tetrahedron · doi:10.1016/s0040-4020(97)00504-8 · Cited by 47 · see citing works

Procedures for the Analyses of Dolastatins 10 and 15 by High Performance Liquid Chromatography

Pettit, G. R., Kantoci, D., Herald, D. L., Barkoczy, J., & Slack, J. A. (1994) · Journal of Liquid Chromatography · doi:10.1080/10826079408013444 · Cited by 6 · see citing works

High-value products from microalgae—their development and commercialisation

Borowitzka, M. A. (2013) · Journal of Applied Phycology · doi:10.1007/s10811-013-9983-9 · Cited by 1,585 · see citing works

Natural products to drugs: natural product-derived compounds in clinical trials

Butler, M. S. (2008) · Natural Product Reports · doi:10.1039/b514294f · Cited by 1,075 · see citing works

Natural product and natural product derived drugs in clinical trials

Butler, M. S., Robertson, A. A. B., & Cooper, M. A. (2014) · Natural Product Reports · doi:10.1039/c4np00064a · Cited by 604 · see citing works

Lessons from the Past and Charting the Future of Marine Natural Products Drug Discovery and Chemical Biology

Gerwick, W. H., & Moore, B. S. (2012) · Chemistry & Biology · doi:10.1016/j.chembiol.2011.12.014 · Cited by 607 · see citing works

Marine natural products as anticancer drugs

Simmons, T. L., Andrianasolo, E., McPhail, K., Flatt, P., & Gerwick, W. H. (2005) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.333.4.2 · Cited by 597 · see citing works

Metabolites from symbiotic bacteria

Piel, J. (2008) · Natural Product Reports · doi:10.1039/b703499g · Cited by 579 · see citing works

Drugs from the seas - current status and microbiological implications

Proksch, P., Edrada‐Ebel, R., & Ebel, R. (2002) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-002-1006-8 · Cited by 572 · see citing works

Marine Natural Products: A Source of Novel Anticancer Drugs

Khalifa, S. A. M., Elias, N., Farag, M. A., Chen, L., Saeed, A., Hegazy, M.-E. F., Moustafa, M. S., Abd El-Wahed, A., Al-Mousawi, S. M., Musharraf, S. G., et al. (2019) · Marine Drugs · doi:10.3390/md17090491 · Cited by 555 · see citing works

Natural products to drugs: natural product derived compounds in clinical trials

Butler, M. S. (2005) · Natural Product Reports · doi:10.1039/b402985m · Cited by 493 · see citing works

Nonproteinogenic Amino Acid Building Blocks for Nonribosomal Peptide and Hybrid Polyketide Scaffolds

Walsh, C. T., O’Brien, R. V., & Khosla, C. (2013) · Angewandte Chemie International Edition · doi:10.1002/anie.201208344 · Cited by 408 · see citing works

Anticancer Drugs from Marine Flora: An Overview

Boopathy, N. S., & Kathiresan, K. (2010) · Journal of Oncology · doi:10.1155/2010/214186 · Cited by 402 · see citing works

Marine Peptides: Bioactivities and Applications

Cheung, R. C. F., Ng, T. B., & Wong, J. H. (2015) · Marine Drugs · doi:10.3390/md13074006 · Cited by 394 · see citing works

Cyanobacteria: an emerging source for drug discovery

Singh, R. K., Tiwari, S. P., Rai, A. K., & Mohapatra, T. M. (2011) · The Journal of Antibiotics · doi:10.1038/ja.2011.21 · Cited by 370 · see citing works

Bio-mining the microbial treasures of the ocean: New natural products

Imhoff, J. F., Labes, A., & Wiese, J. (2011) · Biotechnology Advances · doi:10.1016/j.biotechadv.2011.03.001 · Cited by 347 · see citing works

Natural Products from Cyanobacteria: Focus on Beneficial Activities

Demay, J., Bernard, C., Reinhardt, A., & Marie, B. (2019) · Marine Drugs · doi:10.3390/md17060320 · Cited by 331 · see citing works

Marine-Derived Pharmaceuticals - Challenges and Opportunities

Lindequist, U. (2016) · Biomolecules & Therapeutics · doi:10.4062/biomolther.2016.181 · Cited by 241 · see citing works

An Updated Review on Marine Anticancer Compounds: The Use of Virtual Screening for the Discovery of Small-Molecule Cancer Drugs

Ruiz-Torres, V., Encinar, J. A., Herranz‐López, M., Pérez-Sánchez, A., Galiano, V., Barrajón‐Catalán, E., & Micol, V. (2017) · Molecules · doi:10.3390/molecules22071037 · Cited by 229 · see citing works

A Convolutional Neural Network-Based Approach for the Rapid Annotation of Molecularly Diverse Natural Products

Reher, R., Kim, H. W., Zhang, C., Mao, H. H., Wang, M., Nothias-Scaglia, L.-F., Caraballo‐Rodríguez, A. M., Glukhov, E., Teke, B., Leão, T., et al. (2020) · Journal of the American Chemical Society · doi:10.1021/jacs.9b13786 · Cited by 216 · see citing works

Biosynthetic origin of natural products isolated from marine microorganism–invertebrate assemblages

Simmons, T. L., Coates, R. C., Clark, B. R., Engene, N., Gonzalez, D. J., Esquenazi, E., Dorrestein, P. C., & Gerwick, W. H. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0709851105 · Cited by 215 · see citing works

Pharmaceutical applications of cyanobacteria—A review

Vijayakumar, S., & Menakha, M. (2015) · Journal of Acute Medicine · doi:10.1016/j.jacme.2015.02.004 · Cited by 205 · see citing works

Cyanobacterial bioactive metabolites—A review of their chemistry and biology

Huang, I., & Zimba, P. V. (2019) · Harmful Algae · doi:10.1016/j.hal.2018.11.008 · Cited by 183 · see citing works

Natural products and drug discovery

Newman, D. J. (2022) · National Science Review · doi:10.1093/nsr/nwac206 · Cited by 176 · see citing works

Largazole: From discovery to broad-spectrum therapy

Hong, J., & Luesch, H. (2012) · Natural Product Reports · doi:10.1039/c2np00066k · Cited by 174 · see citing works

Antimalarial Peptides from Marine Cyanobacteria: Isolation and Structural Elucidation of Gallinamide A

Linington, R. G., Clark, B. R., Trimble, E. E., Almanza, A., Ureña, L.-D., Kyle, D. E., & Gerwick, W. H. (2008) · Journal of Natural Products · doi:10.1021/np8003529 · Cited by 167 · see citing works

Bispecific Antibodies and Antibody–Drug Conjugates for Cancer Therapy: Technological Considerations

Shim, H. (2020) · Biomolecules · doi:10.3390/biom10030360 · Cited by 167 · see citing works

New apratoxins of marine cyanobacterial origin from guam and palau

Luesch, H. (2002) · Bioorganic & Medicinal Chemistry · doi:10.1016/s0968-0896(02)00014-7 · Cited by 165 · see citing works

Biological targets and mechanisms of action of natural products from marine cyanobacteria

Salvador‐Reyes, L. A., & Luesch, H. (2015) · Natural Product Reports · doi:10.1039/c4np00104d · Cited by 165 · see citing works

Antimalarial Linear Lipopeptides from a Panamanian Strain of the Marine Cyanobacterium Lyngbya majuscula

McPhail, K. L., Correa, J., Linington, R. G., González, J., Ortega‐Barría, E., Capson, T. L., & Gerwick, W. H. (2007) · Journal of Natural Products · doi:10.1021/np0700772 · Cited by 163 · see citing works

Isolation, Crystal and Solution Structure Determination, and Biosynthesis of Tubulysins—Powerful Inhibitors of Tubulin Polymerization from Myxobacteria

Steinmetz, H., Glaser, N., Herdtweck, E., Sasse, F., Reichenbach, H., & Höfle, G. (2004) · Angewandte Chemie International Edition · doi:10.1002/anie.200460147 · Cited by 163 · see citing works

A functional genomics approach to the mode of action of apratoxin A

Luesch, H., Chanda, S. K., Raya, R. M., DeJesus, P., Orth, A. P., Walker, J. R., Belmonte, J. C. I., & Schultz, P. G. (2006) · Nature Chemical Biology · doi:10.1038/nchembio769 · Cited by 161 · see citing works

Drugs and Drug Candidates from Marine Sources: An Assessment of the Current “State of Play”

Newman, D. M., & Cragg, G. M. L. (2016) · Planta Medica · doi:10.1055/s-0042-101353 · Cited by 160 · see citing works

Mechanism of Action of Tubulysin, an Antimitotic Peptide from Myxobacteria

Khalil, M. W., Sasse, F., Lünsdorf, H., Elnakady, Y. A., & Reichenbach, H. (2006) · ChemBioChem · doi:10.1002/cbic.200500421 · Cited by 159 · see citing works

Potential drugs used in the antibody–drug conjugate (ADC) architecture for cancer therapy

Yaghoubi, S., Karimi, M. H., Lotfinia, M., Gharibi, T., Mahi‐Birjand, M., Kavi, E., Hosseini, F., Sepehr, K. S., Khatami, M., Bagheri, N., et al. (2019) · Journal of Cellular Physiology · doi:10.1002/jcp.28967 · Cited by 153 · see citing works

Marine Anticancer Agents: An Overview with a Particular Focus on Their Chemical Classes

Barreca, M., Spanò, V., Montalbano, A., Cueto, M., Díaz‐Marrero, A. R., Deniz, İ., Erdoğan, A., Bilela, L. L., Moulin, C., de Givenchy, E. T., et al. (2020) · Marine Drugs · doi:10.3390/md18120619 · Cited by 150 · see citing works

Marine cyanobacteria compounds with anticancer properties: A review on the implication of apoptosis

Costa, M., Costa-Rodrigues, J., Fernandes, M. H., Barros, P., Vasconcelos, V., & Martins, R. (2012) · Marine Drugs · doi:10.3390/md10102181 · Cited by 147 · see citing works

Antitumor Peptides from Marine Organisms

Zheng, L.-H., Wang, Y.-J., Sheng, J., Wang, F., Zheng, Y., Lin, X.-K., & Sun, M. (2011) · Marine Drugs · doi:10.3390/md9101840 · Cited by 146 · see citing works

The expanding role of marine microbes in pharmaceutical development

Waters, A. L., Hill, R. T., Place, A. R., & Hamann, M. T. (2010) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2010.09.013 · Cited by 145 · see citing works

Bisebromoamide, a Potent Cytotoxic Peptide from the Marine Cyanobacterium Lyngbya sp.: Isolation, Stereostructure, and Biological Activity

Teruya, T., Sasaki, H., Fukazawa, H., & Suenaga, K. (2009) · Organic Letters · doi:10.1021/ol9020546 · Cited by 141 · see citing works

Discovery of Cytotoxic Dolastatin 10 Analogues with N-Terminal Modifications

Maderna, A., Doroski, M., Subramanyam, C., Porte, A. M., Leverett, C. A., Vetelino, B. C., Chen, Z., Risley, H., Parris, K. D., Pandit, J., et al. (2014) · Journal of Medicinal Chemistry · doi:10.1021/jm501649k · Cited by 136 · see citing works

Marine Organisms as a Rich Source of Biologically Active Peptides

Macedo, M. W. F. S., da Cunha, N. B., Carneiro, J. A., da Costa, R. A., de Alencar, S. A., Cardoso, M. H. E. S., Franco, O. L., & Dias, S. C. (2021) · Frontiers in Marine Science · doi:10.3389/fmars.2021.667764 · Cited by 136 · see citing works

Filamentous tropical marine cyanobacteria: a rich source of natural products for anticancer drug discovery

Tan, L. T. (2010) · Journal of Applied Phycology · doi:10.1007/s10811-010-9506-x · Cited by 135 · see citing works

Unconventional high-value products from microalgae: A review

Abu‐Ghosh, S., Dubinsky, Z., Verdelho, V., & Iluz, D. (2021) · Bioresource Technology · doi:10.1016/j.biortech.2021.124895 · Cited by 135 · see citing works

The intriguing chemistry and biology of sulfur-containing natural products from marine microorganisms (1987–2020)

Hai, Y., Wei, M., Wang, C., Gu, Y., & Shao, C. (2021) · Marine Life Science & Technology · doi:10.1007/s42995-021-00101-2 · Cited by 133 · see citing works

Medicinals for the Millennia

Cragg, G. M. L., & Newman, D. J. (2001) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2001.tb11356.x · Cited by 131 · see citing works

Can Some Marine-Derived Fungal Metabolites Become Actual Anticancer Agents?

Gomes, N. G. M., Lefranc, F., Kijjoa, A., & Robert Kiss, A. (2015) · Marine Drugs · doi:10.3390/md13063950 · Cited by 130 · see citing works

Drug Discovery from Marine Microbes

Gerwick, W. H., & Fenner, A. M. (2012) · Microbial Ecology · doi:10.1007/s00248-012-0169-9 · Cited by 132 · see citing works

Cyanobacteria—From the Oceans to the Potential Biotechnological and Biomedical Applications

Khalifa, S. A. M., Shedid, E. S., Saied, E. M., Jassbi, A. R., Jamebozorgi, F. H., Rateb, M. E., Du, M., Abdel‐Daim, M. M., Kai, G., Alhammady, M. A., et al. (2021) · Marine Drugs · doi:10.3390/md19050241 · Cited by 133 · see citing works

The unique mechanistic transformations involved in the biosynthesis of modular natural products from marine cyanobacteria

Jones, A. C., Monroe, E. A., Eisman, E. B., Gerwick, L. G., Sherman, D. H., & Gerwick, W. H. (2010) · Natural Product Reports · doi:10.1039/c000535e · Cited by 120 · see citing works

Cyanobacterial factories for the production of green energy and value-added products: An integrated approach for economic viability

Rajneesh, Singh, S. P., Pathak, J., & Sinha, R. P. (2016) · Renewable and Sustainable Energy Reviews · doi:10.1016/j.rser.2016.11.110 · Cited by 120 · see citing works

The Natural Products Chemistry of Cyanobacteria

Tidgewell, K. J., Clark, B. R., & Gerwick, W. H. (2010) · Elsevier eBooks · doi:10.1016/b978-008045382-8.00041-1 · Cited by 116 · see citing works

Future directions for the discovery of natural product-derived immunomodulating drugs: an IUPHAR positional review

Wainwright, C. L., Teixeira, M. M., Adelson, D. L., Braga, F. C., Buenz, E. J., Campana, P. R. V., David, B., Glaser, K. B., Harata‐Lee, Y., Howes, M. R., et al. (2022) · Pharmacological Research · doi:10.1016/j.phrs.2022.106076 · Cited by 113 · see citing works

Drugs from the Sea - Opportunities and Obstacles

Proksch, P., Edrada‐Ebel, R., & Ebel, R. (2003) · Marine Drugs · doi:10.3390/md101005 · Cited by 113 · see citing works

Cyanobacteria: potential candidates for drug discovery

Dixit, R. B., & Suseela, M. R. (2013) · Antonie van Leeuwenhoek · doi:10.1007/s10482-013-9898-0 · Cited by 113 · see citing works

Structural diversity of marine cyclic peptides and their molecular mechanisms for anticancer, antibacterial, antifungal, and other clinical applications

Lee, Y., Phat, C., & Hong, S. (2017) · Peptides · doi:10.1016/j.peptides.2017.06.002 · Cited by 109 · see citing works

Hoiamide A, a Sodium Channel Activator of Unusual Architecture from a Consortium of Two Papua New Guinea Cyanobacteria

Pereira, A. R., Cao, Z., Murray, T. F., & Gerwick, W. H. (2009) · Chemistry & Biology · doi:10.1016/j.chembiol.2009.06.012 · Cited by 105 · see citing works

New Drugs from the Sea: Pro-Apoptotic Activity of Sponges and Algae Derived Compounds

Ercolano, G., Cicco, P. D., & Ianaro, A. (2019) · Marine Drugs · doi:10.3390/md17010031 · Cited by 102 · see citing works

Marine Invertebrate Metabolites with Anticancer Activities: Solutions to the “Supply Problem”

Gomes, N. G. M., Dasari, R., Chandra, S., Robert Kiss, A., & Kornienko, A. (2016) · Marine Drugs · doi:10.3390/md14050098 · Cited by 104 · see citing works

Chemical Ecology of Plants: Allelopathy in Aquatic and Terrestrial Ecosystems

(2002) · Birkhäuser Basel eBooks · doi:10.1007/978-3-0348-8109-8 · Cited by 102 · see citing works

Recent Advances in the Development of New Auristatins: Structural Modifications and Application in Antibody Drug Conjugates

Maderna, A., & Leverett, C. A. (2015) · Molecular Pharmaceutics · doi:10.1021/mp500762u · Cited by 98 · see citing works

Gatorbulin-1, a distinct cyclodepsipeptide chemotype, targets a seventh tubulin pharmacological site

Matthew, S., Chen, Q.-Y., Ratnayake, R., Fermaintt, C. S., Lucena‐Agell, D., Bonato, F., Prota, A. E., Lim, S. T., Wang, X., Díaz, J. F., et al. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2021847118 · Cited by 94 · see citing works

Biotechnological Applications of Bioactive Peptides From Marine Sources

Giordano, D., Costantini, M., Coppola, D., Lauritano, C., Núñez‐Pons, L., Ruocco, N., di Prisco, G., Ianora, A., & Verde, C. (2018) · Advances in microbial physiology/Advances in Microbial Physiology · doi:10.1016/bs.ampbs.2018.05.002 · Cited by 92 · see citing works

Santacruzamate A, a Potent and Selective Histone Deacetylase Inhibitor from the Panamanian Marine Cyanobacterium cf. Symploca sp.

Pavlik, C. M., Wong, C. Y. B., Ononye, S. N., Lopéz, D., Engene, N., McPhail, K. L., Gerwick, W. H., & Balunas, M. J. (2013) · Journal of Natural Products · doi:10.1021/np400198r · Cited by 92 · see citing works

Catalytic Asymmetric Synthesis of Trifluoromethylated γ‐Amino Acids through the Umpolung Addition of Trifluoromethyl Imines to Carboxylic Acid Derivatives

Hu, B., & Deng, L. (2017) · Angewandte Chemie International Edition · doi:10.1002/anie.201710915 · Cited by 91 · see citing works

Secondary Metabolites of Marine Microbes: From Natural Products Chemistry to Chemical Ecology

Petersen, L.-E., Kellermann, M. Y., & Schupp, P. J. (2019) · Springer eBooks · doi:10.1007/978-3-030-20389-4_8 · Cited by 92 · see citing works

Cyanobacterial bioactive metabolites—A review of their chemistry and biology

Huang, I., & Zimba, P. V. (2019) · Harmful Algae · doi:10.1016/j.hal.2019.05.001 · Cited by 93 · see citing works

Allelopathy and allelochemicals from microalgae: An innovative source for bio-herbicidal compounds and biocontrol research

Chaïb, S., Pistevos, J. C. A., Bertrand, C., & Bonnard, I. (2021) · Algal Research · doi:10.1016/j.algal.2021.102213 · Cited by 91 · see citing works

A review of pharmacological and toxicological potentials of marine cyanobacterial metabolites

Nagarajan, M., Veerabadhran, M., & Sundararaman, M. (2011) · Journal of Applied Toxicology · doi:10.1002/jat.1717 · Cited by 90 · see citing works

Marine bacteria associated with marine macroorganisms: the potential antimicrobial resources

Zheng, L., Han, X., Chen, H., Lin, W., & Yan, X. (2005) · Annals of Microbiology · Cited by 89 · see citing works

The molecular pharmacology of symplostatin 1: A new antimitotic dolastatin 10 analog

Mooberry, S. L., Leal, R. M., Tinley, T. L., Luesch, H., Moore, R. E., & Corbett, T. H. (2003) · International Journal of Cancer · doi:10.1002/ijc.10982 · Cited by 87 · see citing works

Marine Microorganism-Invertebrate Assemblages: Perspectives to Solve the “Supply Problem” in the Initial Steps of Drug Discovery

Leal, M. C., Sheridan, C., Osinga, R., Dionísio, G., Rocha, R. J. M., Silva, B. B. F. F. D., Rosa, R., & Calado, R. (2014) · Marine Drugs · doi:10.3390/md12073929 · Cited by 88 · see citing works

Integrating Molecular Networking and Biological Assays To Target the Isolation of a Cytotoxic Cyclic Octapeptide, Samoamide A, from an American Samoan Marine Cyanobacterium

Naman, C. B., Rattan, R., Nikoulina, S. E., Lee, J., Miller, B. W., Moss, N. A., Armstrong, L., Boudreau, P. D., Debonsi, H. M., Valeriote, F. A., et al. (2017) · Journal of Natural Products · doi:10.1021/acs.jnatprod.6b00907 · Cited by 84 · see citing works

Sepia Ink Oligopeptide Induces Apoptosis in Prostate Cancer Cell Lines via Caspase-3 Activation and Elevation of Bax/Bcl-2 Ratio

Huang, F., Yang, Z., Yu, D., Wang, J., Li, R., & Ding, G. (2012) · Marine Drugs · doi:10.3390/md10102153 · Cited by 84 · see citing works

Belamide A, a new antimitotic tetrapeptide from a Panamanian marine cyanobacterium

Simmons, T. L., McPhail, K. L., Ortega‐Barría, E., Mooberry, S. L., & Gerwick, W. H. (2006) · Tetrahedron Letters · doi:10.1016/j.tetlet.2006.03.082 · Cited by 84 · see citing works

Developments of Cyanobacteria for Nano-Marine Drugs: Relevance of Nanoformulations in Cancer Therapies

Bajpai, V. K., Shukla, S., Kang, S., Hwang, S. K., Song, X., Huh, Y. S., & Han, Y. (2018) · Marine Drugs · doi:10.3390/md16060179 · Cited by 81 · see citing works

Combinatorial Strategies by Marine Cyanobacteria: Symplostatin 4, an Antimitotic Natural Dolastatin 10/15 Hybrid that Synergizes with the Coproduced HDAC Inhibitor Largazole

Taori, K., Liu, Y., Paul, V. J., & Luesch, H. (2009) · ChemBioChem · doi:10.1002/cbic.200900192 · Cited by 81 · see citing works

Combined LC–MS/MS and Molecular Networking Approach Reveals New Cyanotoxins from the 2014 Cyanobacterial Bloom in Green Lake, Seattle

Teta, R., Sala, G. D., Glukhov, E., Gerwick, L. G., Gerwick, W. H., Mangoni, A., & Costantino, V. (2015) · Environmental Science & Technology · doi:10.1021/acs.est.5b04415 · Cited by 81 · see citing works

Biogenetic Diversity of Cyanobacterial Metabolites

Wagoner, R. M. V., Drummond, A. K., & Wright, J. L. C. (2007) · Advances in applied microbiology · doi:10.1016/s0065-2164(06)61004-6 · Cited by 80 · see citing works

Veraguamides A−G, Cyclic Hexadepsipeptides from a Dolastatin 16-Producing Cyanobacterium Symploca cf. hydnoides from Guam

Salvador, L. A., Biggs, J. S., Paul, V. J., & Luesch, H. (2011) · Journal of Natural Products · doi:10.1021/np200076t · Cited by 80 · see citing works

Microbial natural products: molecular blueprints for antitumor drugs

Giddings, L., & Newman, D. J. (2013) · Journal of Industrial Microbiology & Biotechnology · doi:10.1007/s10295-013-1331-1 · Cited by 78 · see citing works

Apoptosis inducing lead compounds isolated from marine organisms of potential relevance in cancer treatment

Beesoo, R., Neergheen, V. S., Bhagooli, R., & Bahorun, T. (2014) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2014.03.005 · Cited by 78 · see citing works

Natural product-derived compounds in clinical trials and drug approvals

Butler, M. S., Capon, R. J., Blaskovich, M. A. T., & Henderson, I. R. (2025) · Natural Product Reports · doi:10.1039/d5np00031a · Cited by 77 · see citing works

The Marine Cyanobacterial Metabolite Gallinamide A Is a Potent and Selective Inhibitor of Human Cathepsin L

Miller, B. W., Friedman, A. J., Choi, H., Hogan, J., McCammon, J. A., HOOK, V. Y. H., & Gerwick, W. H. (2013) · Journal of Natural Products · doi:10.1021/np400727r · Cited by 74 · see citing works

Cytotoxic and antitumor peptides as novel chemotherapeutics

Luan, X., Wu, Y., Shen, Y., Zhang, H., Zhou, Y., Chen, H., Nagle, D. G., & Zhang, W. (2020) · Natural Product Reports · doi:10.1039/d0np00019a · Cited by 72 · see citing works

Caldora penicillata gen. nov., comb. nov. (Cyanobacteria), a pantropical marine species with biomedical relevance

Engene, N., Tronholm, A., Salvador‐Reyes, L. A., Luesch, H., & Paul, V. J. (2015) · Journal of Phycology · doi:10.1111/jpy.12309 · Cited by 71 · see citing works

Utilizing the Power of Microbial Genetics to Bridge the Gap Between the Promise and the Application of Marine Natural Products

Fortman, J. L., & Sherman, D. H. (2005) · ChemBioChem · doi:10.1002/cbic.200400428 · Cited by 68 · see citing works

Cyanobacteria as Natural Therapeutics and Pharmaceutical Potential: Role in Antitumor Activity and as Nanovectors

Qamar, H., Hussain, K., Soni, A., Khan, A., Hussain, T., & Chénais, B. (2021) · Molecules · doi:10.3390/molecules26010247 · Cited by 69 · see citing works

Caylobolide B, a Macrolactone from Symplostatin 1-Producing Marine Cyanobacteria Phormidium spp. from Florida

Salvador, L. A., Paul, V. J., & Luesch, H. (2010) · Journal of Natural Products · doi:10.1021/np100467d · Cited by 66 · see citing works

Cyanobacteria and microalgae: A renewable source of bioactive compounds and other chemicals

Encarnação, T., Pais, A. A. C. C., Campos, M. G., & Burrows, H. D. (2015) · Science Progress · doi:10.3184/003685015x14298590596266 · Cited by 65 · see citing works

Discovery and Development of Dolastatin 10-Derived Antibody Drug Conjugate Anticancer Drugs

Singh, S. B. (2022) · Journal of Natural Products · doi:10.1021/acs.jnatprod.1c01135 · Cited by 65 · see citing works

Emerging biopharmaceuticals from bioactive peptides derived from marine organisms

Anjum, K., Abbas, S. Q., Akhter, N., Shagufta, B. I., Shah, S. A. A., & Hassan, S. S. U. (2016) · Chemical Biology & Drug Design · doi:10.1111/cbdd.12925 · Cited by 63 · see citing works

Long-read metagenomics of soil communities reveals phylum-specific secondary metabolite dynamics

Goethem, M. W. V., Osborn, A. R., Bowen, B. P., Andeer, P. F., Swenson, T. L., Clum, A., Riley, R. W., He, G., Koriabine, M., Sandor, L., et al. (2021) · Communications Biology · doi:10.1038/s42003-021-02809-4 · Cited by 62 · see citing works

Alkynyl-Containing Peptides of Marine Origin: A Review

Chai, Q.-Y., Yang, Z., Lin, H., & Han, B. (2016) · Marine Drugs · doi:10.3390/md14110216 · Cited by 63 · see citing works

The chemistry of gliding bacteria

Nett, M., & König, G. M. (2007) · Natural Product Reports · doi:10.1039/b612668p · Cited by 60 · see citing works

From Seabed to Bedside: A Review on Promising Marine Anticancer Compounds

Wang, E., Sorolla, M. A., Krishnan, P. D. G., & Sorolla, A. (2020) · Biomolecules · doi:10.3390/biom10020248 · Cited by 59 · see citing works

Natural Bioactive Thiazole-Based Peptides from Marine Resources: Structural and Pharmacological Aspects

Dahiya, R., Dahiya, S., Fuloria, N. K., Kumar, S., Mourya, R., Chennupati, S. V., Jankie, S., Gautam, H., Singh, S. K., Karan, S. K., et al. (2020) · Marine Drugs · doi:10.3390/md18060329 · Cited by 59 · see citing works

A Chemical Study of Cyclic Depsipeptides Produced by a Sponge-Derived Fungus

Amagata, T., Morinaka, B. I., Amagata, A., Tenney, K., Valeriote, F. A., Lobkovsky, E. B., Clardy, J., & Crews, P. (2006) · Journal of Natural Products · doi:10.1021/np060178k · Cited by 58 · see citing works

Peptides with anticancer use or potential

Janin, Y. L. (2003) · Amino Acids · doi:10.1007/s00726-002-0349-x · Cited by 56 · see citing works

Microalgae in Medicine and Human Health

Borowitzka, M. A. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-811405-6.00009-8 · Cited by 56 · see citing works

Biomedical Applications of Biosynthesized Gold Nanoparticles from Cyanobacteria: an Overview

Mandhata, C. P., Sahoo, C. R., & Padhy, R. N. (2022) · Biological Trace Element Research · doi:10.1007/s12011-021-03078-2 · Cited by 55 · see citing works

Antimicrobial Potential of Bacteria Associated with Marine Sea Slugs from North Sulawesi, Indonesia

Böhringer, N., Fisch, K. M., Schillo, D., Bara, R. A., Hertzer, C., Grein, F., Eisenbarth, J.-H., Kaligis, F. G., Schneider, T., Wägele, H., et al. (2017) · Frontiers in Microbiology · doi:10.3389/fmicb.2017.01092 · Cited by 54 · see citing works

Symplostatin 3, a New Dolastatin 10 Analogue from the Marine Cyanobacterium Symploca sp. VP452

Luesch, H., Yoshida, W. Y., Moore, R. E., Paul, V. J., Mooberry, S. L., & Corbett, T. H. (2001) · Journal of Natural Products · doi:10.1021/np010317s · Cited by 84 · see citing works

Symplostatin 1: A Dolastatin 10 Analogue from the Marine Cyanobacterium Symploca hydnoides

Harrigan, G. G., Luesch, H., Yoshida, W. Y., Moore, R. E., Nagle, D. G., Paul, V. J., Mooberry, S. L., Corbett, T. H., & Valeriote, F. A. (1998) · Journal of Natural Products · doi:10.1021/np980321c · Cited by 133 · see citing works

The molecular pharmacology of symplostatin 1: A new antimitotic dolastatin 10 analog

Mooberry, S. L., Leal, R. M., Tinley, T. L., Luesch, H., Moore, R. E., & Corbett, T. H. (2003) · International Journal of Cancer · doi:10.1002/ijc.10982 · Cited by 87 · see citing works

Symplostatin 2: A Dolastatin 13 Analogue from the Marine Cyanobacterium Symploca hydnoides

Harrigan, G. G., Luesch, H., Yoshida, W. Y., Moore, R. E., Nagle, D. G., & Paul, V. J. (1999) · Journal of Natural Products · doi:10.1021/np980553b · Cited by 148 · see citing works

Research advances on marine antitumor peptides dolastatin 10

Jia-xi, S. (2011) · Yixue yanjiusheng xuebao · Cited by 2 · see citing works