The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Bioactive Novel Polyphenols from the Fruit of Manilkara zapota (Sapodilla)
Abstract
Activity-guided fractionation of a methanol extract from the fruit of Manilkara zapota cv. Tikal resulted in the isolation of two new antioxidants, methyl 4-O-galloylchlorogenate (1) and 4-O-galloylchlorogenic acid (2), along with eight known polyphenolic antioxidants, namely, methyl chlorogenate (3), dihydromyricetin (4), quercitrin (5), myricitrin (6), (+)-catechin (7), (-)-epicatechin (8), (+)-gallocatechin (9), and gallic acid (10). Of the 10 polyphenols, 1 showed the highest antioxidant activity (IC(50) = 12.9 microM) in the 1,1-diphenyl-2-picrylhydrazyl (DPPH) free-radical assay and displayed cytotoxicity in the HCT-116 and SW-480 human colon cancer cell lines with IC(50) values of 190 and 160 microM, respectively. Compound 2 showed high antioxidant activity (IC(50) = 23.5 microM) in the DPPH free-radical assay and displayed cytotoxicity in the HCT-116 and SW-480 human colon cancer cell lines with IC(50) values of 154 and 134 microM, respectively.
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Cites
An investigation of antioxidant capacity of fruits in Singapore markets
Leong, L. P., & Shui, G. (2002) · Food Chemistry · doi:10.1016/s0308-8146(01)00251-5 · Cited by 1,091
Cited by
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Mahattanatawee, K., Manthey, J. A., Luzio, G., Talcott, S. T., Goodner, K., & Baldwin, E. A. (2006) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf060566s · Cited by 408
Priscilla, D. H., & Prince, P. S. M. (2009) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2008.12.012 · Cited by 342
Rahimifard, M., Baeeri, M., Bahadar, H., Moini-Nodeh, S., Khalid, M., Haghi-Aminjan, H., Mohammadian, H., & Abdollahi, M. (2020) · Molecules · doi:10.3390/molecules25245875 · Cited by 61
RetractedDevatkal, S. K., Kumboj, R., & Paul, D. (2014) · Journal of Food Science and Technology · doi:10.1007/s13197-011-0508-8 · Cited by 51
Metadata
- Authors
- Ma, J., Luo, X.-D., Protiva, P., Yang, H., Ma, C., Basile, M. J., Weinstein, I. B., & Kennelly, E. J.
- Venue
- Journal of Natural Products
- Publisher
- American Chemical Society (ACS)
- Published
- 2003-06-12
- Volume
- 66
- Issue
- 7
- Pages
- 983-986
- ISSN
- 0163-3864 (ISSN-L)
- 1520-6025
- OpenAlex
- W1997572728
- Cited by
- 191
- References
- 1
- FWCI
- 1.29
- Type
- journal article
- Language
- en
- Open access
- closed
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- Ma, J., Luo, X.-D., Protiva, P., Yang, H., Ma, C., Basile, M. J., Weinstein, I. B., & Kennelly, E. J. (2003). Bioactive Novel Polyphenols from the Fruit of Manilkara zapota (Sapodilla). Journal of Natural Products. https://doi.org/10.1021/np020576x
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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