Cytochrome P3A4 Inhibitors and Other Constituents of Fibraurea tinctoria
Abstract
Four new furanoditerpenoids, fibrauretin A ( 1), fibrauretinoside A ( 2), epi-fibrauretinoside A ( 3), and epi-12-palmatoside G ( 4), and a new ecdysteroid glucoside, fibraurecdyside A ( 5), together with seven known compounds including two furanoditerpenoids ( 6 and 7), an ecdysteroid ( 8), and four quaternary protoberberine alkaloids ( 9- 12) were isolated from the stems of Fibraurea tinctoria. The structures of 1- 5 were established on the basis of spectroscopic evidence. Among these compounds, palmatine ( 9) and jatrorrhizine ( 10) showed inhibitory effects against cytochrome P450 3A4 (CYP3A4) with IC 50 values of 0.9 and 2.1 microM, respectively.
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Fibraurecdyside A showed no significant inhibition of CYP3A4.
“Evaluated inhibitory effects against cytochrome P450 3A4 (CYP3A4) and no significant activity have been observed.”
From The Phytochemical, Biological, and Medicinal Attributes of Phytoecdysteroids: An Updated Review (2021) · cites this paper as [139]
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The Phytochemical, Biological, and Medicinal Attributes of Phytoecdysteroids: An Updated Review
Das, N., Mishra, S. K., Bishayee, A., Ali, E. S., & Bishayee, A. (2021) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2020.10.012 · Cited by 115 · see citing works
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- Authors
- Su, C.-R., Ueng, Y.-F., Dung, N. X., Vijaya Bhaskar Reddy, M., & Wu, T.-S.
- Affiliations
- Providence University (TW)
- Department of Chemistry, National Cheng Kung University, Tainan 701, Taiwan, Republic of China, National Research Institute of Chinese Medicine, Taipei 112, Taiwan, Republic of China, Department of Chemistry, College of Natural Sciences, Hanoi National University, Hanoi 10000, Vietnam, and Department of Applied Chemistry, Providence University, Taichung 433, Taiwan, Republic of China
- Corresponding author
- Wu, Tian-Shung
- Venue
- Journal of Natural Products
- Publisher
- American Chemical Society (ACS)
- Published
- 2007-11-10
- Volume
- 70
- Issue
- 12
- Pages
- 1930-1933
- ISSN
- 0163-3864 (ISSN-L)
- 1520-6025
- OpenAlex
- W1978676888
- Cited by
- 39
- References
- 14
- Citations by year
- 2026: 3 · 2024: 2 · 2023: 4 · 2022: 2 · 2021: 1 · 2020: 2 · 2019: 2 · 2018: 1 · 2017: 2 · 2016: 1 · 2015: 1 · 2014: 6 · 2013: 4 · 2012: 4
- FWCI
- 0.27
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Natural Products (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bioactive Natural Diterpenoids Research
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Phytochemistry and Biological Activities
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Biological Activity of Diterpenoids and Biflavonoids
- Keywords
- protoberberine alkaloids, CYP3A4 inhibitors, palmatine, jatrorrhizine, natural product isolation, structure elucidation
- MeSH terms
- Diterpenes, Enzyme Inhibitors, Furans, Plants, Medicinal, Vietnam, Molecular Structure, Plant Stems, Menispermaceae, Cytochrome P-450 CYP3A, Cytochrome P-450 Enzyme Inhibitors
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