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Annonaceous Acetogenins: A Review
Abstract
The Annonaceous acetogenins are a series of apparently polyketide-derived fatty acid derivatives that possess tetrahydrofuran rings and a methylated gamma-lactone (sometimes rearranged to a methyl ketolactone) with various hydroxyl, acetoxyl, and/or ketoxyl groups along the hydrocarbon chain. They exhibit a broad range of potent biological activities (cytotoxicity, antitumor, antimalarial, antimicrobial, immunosuppressant, antifeedant, and pesticidal). The sources, isolation, chemistry, biogenesis, and biological actions of these compounds, published to date, are tabulated and discussed. Strategies for structural elucidation are reviewed, and structural revisions and refinements are suggested for some of the previously published compounds.
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Cited by
Annonaceous Acetogenins: Recent Progress
Alali, F. Q., Liu, X.-X., & McLaughlin, J. L. (1999) · Journal of Natural Products · doi:10.1021/np980406d · Cited by 818
Self-citationMoghadamtousi, S., Fadaeinasab, M., Nikzad, S., Mohan, G., Ali, H., & Kadir, H. (2015) · International Journal of Molecular Sciences · doi:10.3390/ijms160715625 · Cited by 577
Recent advances in annonaceous acetogenins
Zeng, L., Ye, Q., Oberlies, N. H., Shi, G., Gu, Z.-M., He, K., & McLaughlin, J. L. (1996) · Natural Product Reports · doi:10.1039/np9961300275 · Cited by 355
Self-citationPaw Paw and Cancer: Annonaceous Acetogenins from Discovery to Commercial Products
McLaughlin, J. L. (2008) · Journal of Natural Products · doi:10.1021/np800191t · Cited by 294
Self-citationMoghadamtousi, S. Z., Rouhollahi, E., Hajrezaie, M., Karimian, H., Abdulla, M. A., & Kadir, H. A. (2015) · International Journal of Surgery · doi:10.1016/j.ijsu.2015.03.026 · Cited by 93
Metadata
- Authors
- Rupprecht, J. K., Hui, Y.-H., & McLaughlin, J. L.
- Venue
- Journal of Natural Products
- Publisher
- American Chemical Society (ACS)
- Published
- 1990-03
- Volume
- 53
- Issue
- 2
- Pages
- 237-278
- ISSN
- 0163-3864 (ISSN-L)
- 1520-6025
- OpenAlex
- W2000756267
- Cited by
- 508
- References
- 0
- FWCI
- 8.80
- Type
- journal article
- Language
- en
- Open access
- closed
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