Cited by 32Sesquiterpenes and Asteraceae StudiesPhytochemical compounds biological activitiesBioactive Natural Diterpenoids Research

Crystal structure of artemisinic acid: A possible biogenetic precursor of antimalarial artemisinin from Artemisia annua

Misra, L. N., Ahmad, A., Thakur, R. S., Lotter, H., Wagner, H.·1993·Journal of Natural Products

Abstract

Artemisinic acid [1], a possible biogenetic precursor of the antimalarial artemisinin [2], was isolated from the hexane extract of Artemisia annua. X-ray crystallography of the dimer of artemisinic acid shows that the cyclization during intermolecular hydrogen bonding occurs by the opposite orientation of the alpha, beta-methylene group in each molecule. Complete spectroscopic data of 1 are also given.

Integrity signals

Registry

Crossref · 10.1021/np50092a005

Cites

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Cited by

Sorted by citations

Authors
Misra, L. N., Ahmad, A., Thakur, R. S., Lotter, H., & Wagner, H.
Affiliations
Central Institute of Medicinal and Aromatic Plants (IN)
Venue
Journal of Natural Products
Published
1993-02
Volume
56
Issue
2
Pages
215-219
ISSN
  • 0163-3864 (ISSN-L)
  • 1520-6025
OpenAlex
W1987810203
Cited by
32
References
0
Citations by year
2025: 1 · 2024: 1 · 2022: 1 · 2020: 2 · 2019: 2 · 2018: 1 · 2017: 2 · 2014: 1 · 2013: 3 · 2012: 1
FWCI
0.80
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Natural Products (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Sesquiterpenes and Asteraceae Studies
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Phytochemical compounds biological activities
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bioactive Natural Diterpenoids Research
Keywords
artemisinic acid, artemisinin, Artemisia annua, crystal structure, dimers, biogenetic precursor, antimalarial compounds, intermolecular hydrogen bonding, cyclization, natural product isolation
MeSH terms
Antimalarials, Crystallization, Cyclization, Drugs, Chinese Herbal, Hydrogen Bonding, Molecular Conformation, Magnetic Resonance Spectroscopy, Sesquiterpenes, X-Ray Diffraction, Artemisinins

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review