Synthesis of labelled dihydroartemisinic acid
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The final transformations to artemisinin (495) in phase 3 may be non-enzymatic, supported by in vivo and in vitro studies under conditions relevant to the living plant.
“The proposal that the final transformations to artemisinin (495) in phase 3 may be non-enzymatic also receives strong support both from in vivo studies [168,185] and from experiments which have been performed in vitro [167,193,218], under conditions that are relevant to the living plant.”
From The Biosynthesis of Artemisinin (Qinghaosu) and the Phytochemistry of Artemisia annua L. (Qinghao) (2010) · cites this paper as [168]
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- Authors
- Brown, G. D., & Sy, L.-K.
- Affiliations
- University Grants Committee (HK)
- Corresponding author
- Brown, Geoffrey D
- ORCID
- Brown, Geoffrey D
- Venue
- Tetrahedron
- Publisher
- Elsevier BV
- Published
- 2004-01
- Volume
- 60
- Issue
- 5
- Pages
- 1125-1138
- ISSN
- 0040-4020 (ISSN-L)
- OpenAlex
- W1998162025
- Cited by
- 23
- References
- 24
- Citations by year
- 2025: 3 · 2024: 1 · 2020: 2 · 2019: 1 · 2017: 1 · 2016: 2 · 2015: 2 · 2013: 1 · 2012: 1
- FWCI
- 0.46
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Tetrahedron (publishedVersion)
- The HKU Scholars Hub (University of Hong Kong) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Plant biochemistry and biosynthesis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Sesquiterpenes and Asteraceae Studies
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Chemical Reactions and Isotopes
- Keywords
- dihydroartemisinic acid, artemisinin, isotopic labeling, isotope enrichment, biosynthesis, sesquiterpenes, Artemisia annua
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