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Kinase Inhibitors from Polygonum cuspidatum
Open accessAbstract
Bioassay-directed fractionation of a medicinal plant, Polygonum cuspidatum (Polygonaceae), has led to the discovery of a hydroxystilbene, resveratrol [1], as an inhibitor of a protein-tyrosine kinase (p56lck) partially purified from bovine thymus. Both trans and cis isomers of resveratrol possess comparable protein-tyrosine kinase inhibitory activity. Comparison of the IC50 values of resveratrol for protein-tyrosine kinase inhibitory activity with those of piceid (resveratrol-O3-beta-glucoside) [2] and resveratrol-O4'-beta-glucoside [3] shows the requirement of free hydroxyl groups on both phenyl rings for the protein-tyrosine kinase inhibition. Protein kinase C inhibitory analysis suggests the requirements of two free hydroxyl groups on one phenyl ring only.
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Cited by
Cancer chemopreventive activity of resveratrol, a natural product derived from grapes
Jang, M., Cai, L., Udeani, G. O., Slowing, K. V., Thomas, C. F., Beecher, C. W. W., Fong, H. H. S., Farnsworth, N. R., Kinghorn, A. D., Mehta, R. G., et al. (1997) · Science · doi:10.1126/science.275.5297.218 · Cited by 4,935
Yang, Y., Li, S., Yang, Q., Shi, Y., Zheng, M., Liu, Y., Chen, F., Song, G., Xu, H., Wan, T., et al. (2014) · Cellular Physiology and Biochemistry · doi:10.1159/000358696 · Cited by 3,253
Resveratrol: A molecule whose time has come? And gone?
Soleas, G. J., Diamandis, E. P., & Goldberg, D. M. (1997) · Clinical Biochemistry · doi:10.1016/s0009-9120(96)00155-5 · Cited by 849
Metabolism and roles of stilbenes in plants
Chong, J., Poutaraud, A., & Hugueney, P. (2009) · Plant Science · doi:10.1016/j.plantsci.2009.05.012 · Cited by 664
Biological Effects of Resveratrol
Bhat, K. P. L., Kosmeder, J. W., & Pezzuto, J. M. (2001) · Antioxidants & Redox Signaling · doi:10.1089/152308601317203567 · Cited by 507
Metadata
- Authors
- Jayatilake, G. S., Jayasuriya, H., Lee, E.-S., Koonchanok, N. M., Geahlen, R. L., Ashendel, C. L., McLaughlin, J. L., & Chang, C.-J.
- Venue
- Journal of Natural Products
- Publisher
- American Chemical Society (ACS)
- Published
- 1993-10
- Volume
- 56
- Issue
- 10
- Pages
- 1805-1810
- ISSN
- 0163-3864 (ISSN-L)
- 1520-6025
- OpenAlex
- W1987062124
- Cited by
- 233
- References
- 0
- FWCI
- 5.80
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Jayatilake, G. S., Jayasuriya, H., Lee, E.-S., Koonchanok, N. M., Geahlen, R. L., Ashendel, C. L., McLaughlin, J. L., & Chang, C.-J. (1993). Kinase Inhibitors from Polygonum cuspidatum. Journal of Natural Products. https://doi.org/10.1021/np50100a021
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