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Kinase Inhibitors from Polygonum cuspidatum
Open accessAbstract
Bioassay-directed fractionation of a medicinal plant, Polygonum cuspidatum (Polygonaceae), has led to the discovery of a hydroxystilbene, resveratrol [1], as an inhibitor of a protein-tyrosine kinase (p56lck) partially purified from bovine thymus. Both trans and cis isomers of resveratrol possess comparable protein-tyrosine kinase inhibitory activity. Comparison of the IC50 values of resveratrol for protein-tyrosine kinase inhibitory activity with those of piceid (resveratrol-O3-beta-glucoside) [2] and resveratrol-O4'-beta-glucoside [3] shows the requirement of free hydroxyl groups on both phenyl rings for the protein-tyrosine kinase inhibition. Protein kinase C inhibitory analysis suggests the requirements of two free hydroxyl groups on one phenyl ring only.
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Cited by
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Jang, M., Cai, L., Udeani, G. O., Slowing, K. V., Thomas, C. F., Beecher, C. W. W., Fong, H. H. S., Farnsworth, N. R., Kinghorn, A. D., Mehta, R. G., et al. (1997) · Science · doi:10.1126/science.275.5297.218 · Cited by 4,935
Yang, Y., Li, S., Yang, Q., Shi, Y., Zheng, M., Liu, Y., Chen, F., Song, G., Xu, H., Wan, T., et al. (2014) · Cellular Physiology and Biochemistry · doi:10.1159/000358696 · Cited by 3,253
Resveratrol: A molecule whose time has come? And gone?
Soleas, G. J., Diamandis, E. P., & Goldberg, D. M. (1997) · Clinical Biochemistry · doi:10.1016/s0009-9120(96)00155-5 · Cited by 849
Metabolism and roles of stilbenes in plants
Chong, J., Poutaraud, A., & Hugueney, P. (2009) · Plant Science · doi:10.1016/j.plantsci.2009.05.012 · Cited by 664
Biological Effects of Resveratrol
Bhat, K. P. L., Kosmeder, J. W., & Pezzuto, J. M. (2001) · Antioxidants & Redox Signaling · doi:10.1089/152308601317203567 · Cited by 507
Interaction of β-Lactoglobulin with Resveratrol and its Biological Implications
Liang, L., Tajmir-Riahi, H. A., & Subirade, M. (2008) · Biomacromolecules · doi:10.1021/bm700728k · Cited by 472
Resveratrol: Isomeric Molar Absorptivities and Stability
Trela, B. C., & Waterhouse, A. L. (1996) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf9504576 · Cited by 440
Isoflavones, lignans and stilbenes - origins, metabolism and potential importance to human health
Cassidy, A., Hanley, B., & Lamuela-Raventos, R. M. (2000) · Journal of the Science of Food and Agriculture · doi:10.1002/(sici)1097-0010(20000515)80:7<1044::aid-jsfa586>3.0.co;2-n · Cited by 313
Saifi, S., Ashraf, A., Hasan, G. M., Shamsi, A., & Hassan, M. I. (2024) · Fitoterapia · doi:10.1016/j.fitote.2023.105811 · Cited by 25
Metadata
- Authors
- Jayatilake, G. S., Jayasuriya, H., Lee, E.-S., Koonchanok, N. M., Geahlen, R. L., Ashendel, C. L., McLaughlin, J. L., & Chang, C.-J.
- Venue
- Journal of Natural Products
- Publisher
- American Chemical Society (ACS)
- Published
- 1993-10
- Volume
- 56
- Issue
- 10
- Pages
- 1805-1810
- ISSN
- 0163-3864 (ISSN-L)
- 1520-6025
- OpenAlex
- W1987062124
- Cited by
- 233
- References
- 0
- FWCI
- 5.80
- Type
- journal article
- Language
- en
- Open access
- hybrid
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