Mansouramycins A–D, cytotoxic isoquinolinequinones from a marine Streptomycete
Abstract
Chemical screening of the ethyl acetate extract from the marine-derived Streptomyces sp. isolate Mei37 resulted in five isoquinolinequinones, four new derivatives, mansouramycin A-D (1, 3-5), and the known 3-methyl-7-(methylamino)-5,8-isoquinolinedione (2). Their structures were elucidated by NMR and MS techniques and by comparison with related compounds. Cytotoxicity profiling of the mansouramycins in a panel of up to 36 tumor cell lines indicated significant cytotoxicity of several derivatives, with pronounced selectivity for non-small cell lung cancer, breast cancer, melanoma, and prostate cancer cells.
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- Authors
- Hawas, U. W., Shaaban, M., Shaaban, K. A., Speitling, M., Maier, A., Kelter, G., Fiebig, H. H., Meiners, M., Helmke, E., & Laatsch, H.
- Affiliations
- Alfred-Wegener-Institut Helmholtz-Zentrum für Polar- und Meeresforschung (DE)
- Corresponding author
- Laatsch, Hartmut
- ORCID
- Venue
- Journal of Natural Products
- Publisher
- American Chemical Society (ACS)
- Published
- 2009-11-18
- Volume
- 72
- Issue
- 12
- Pages
- 2120-2124
- ISSN
- 0163-3864 (ISSN-L)
- 1520-6025
- OpenAlex
- W1966128411
- Cited by
- 116
- References
- 27
- Citations by year
- 2026: 3 · 2025: 7 · 2024: 8 · 2023: 9 · 2022: 10 · 2021: 6 · 2020: 6 · 2019: 8 · 2018: 3 · 2017: 10 · 2016: 9 · 2015: 4 · 2014: 6 · 2013: 7 · 2012: 9
- FWCI
- 4.57
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Natural Products (publishedVersion)
- PubMed (publishedVersion)
- Helmholtz-Zentrum für Polar-und Meeresforschung (Alfred-Wegener-Institut) (submittedVersion)
- Topics
- Health Sciences › Medicine › Pharmacology › Microbial Natural Products and Biosynthesis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Synthesis and Biological Activity
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biotechnology › Marine Sponges and Natural Products
- Keywords
- marine Streptomyces, cytotoxic natural products, structure elucidation, cancer cell lines, tumor selectivity, non-small cell lung cancer, breast cancer, melanoma, prostate cancer
- MeSH terms
- Antineoplastic Agents, Drug Screening Assays, Antitumor, Female, Humans, Isoquinolines, Male, Marine Biology, Microbial Sensitivity Tests, Streptomyces, Molecular Structure, Nuclear Magnetic Resonance, Biomolecular
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