Cited by 116Microbial Natural Products and BiosynthesisSynthesis and Biological ActivityMarine Sponges and Natural Products

Mansouramycins A–D, cytotoxic isoquinolinequinones from a marine Streptomycete

Hawas, Usama W., Shaaban, Mohamed, Shaaban, Khaled A., Speitling, Michael, Maier, Armin, Kelter, Gerhard, Fiebig, Heinz H., Meiners, Marinus +2 more·2009·Journal of Natural Products

Abstract

Chemical screening of the ethyl acetate extract from the marine-derived Streptomyces sp. isolate Mei37 resulted in five isoquinolinequinones, four new derivatives, mansouramycin A-D (1, 3-5), and the known 3-methyl-7-(methylamino)-5,8-isoquinolinedione (2). Their structures were elucidated by NMR and MS techniques and by comparison with related compounds. Cytotoxicity profiling of the mansouramycins in a panel of up to 36 tumor cell lines indicated significant cytotoxicity of several derivatives, with pronounced selectivity for non-small cell lung cancer, breast cancer, melanoma, and prostate cancer cells.

Integrity signals

Registry

Crossref · 10.1021/np900160g

Cites

27 of 27 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Hawas, U. W., Shaaban, M., Shaaban, K. A., Speitling, M., Maier, A., Kelter, G., Fiebig, H. H., Meiners, M., Helmke, E., & Laatsch, H.
Affiliations
Alfred-Wegener-Institut Helmholtz-Zentrum für Polar- und Meeresforschung (DE)
Corresponding author
Laatsch, Hartmut
Venue
Journal of Natural Products
Published
2009-11-18
Volume
72
Issue
12
Pages
2120-2124
ISSN
  • 0163-3864 (ISSN-L)
  • 1520-6025
OpenAlex
W1966128411
Cited by
116
References
27
Citations by year
2026: 3 · 2025: 7 · 2024: 8 · 2023: 9 · 2022: 10 · 2021: 6 · 2020: 6 · 2019: 8 · 2018: 3 · 2017: 10 · 2016: 9 · 2015: 4 · 2014: 6 · 2013: 7 · 2012: 9
FWCI
4.57
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Natural Products (publishedVersion)
  • PubMed (publishedVersion)
  • Helmholtz-Zentrum für Polar-und Meeresforschung (Alfred-Wegener-Institut) (submittedVersion)
Topics
  • Health Sciences › Medicine › Pharmacology › Microbial Natural Products and Biosynthesis
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Synthesis and Biological Activity
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Biotechnology › Marine Sponges and Natural Products
Keywords
marine Streptomyces, cytotoxic natural products, structure elucidation, cancer cell lines, tumor selectivity, non-small cell lung cancer, breast cancer, melanoma, prostate cancer
MeSH terms
Antineoplastic Agents, Drug Screening Assays, Antitumor, Female, Humans, Isoquinolines, Male, Marine Biology, Microbial Sensitivity Tests, Streptomyces, Molecular Structure, Nuclear Magnetic Resonance, Biomolecular

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review