Immense essence of excellence: Marine microbial bioactive compounds

Marine natural products

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Bioactive Microbial Metabolites: A Personal View

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Salinosporamide A: A Highly Cytotoxic Proteasome Inhibitor from a Novel Microbial Source, a Marine Bacterium of the New Genus <i>Salinospora</i>

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Marine cyanobacteria—a prolific source of natural products

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Biogeographical distribution and diversity of microbes in methane hydrate-bearing deep marine sediments on the Pacific Ocean Margin

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The odyssey of marine pharmaceuticals: a current pipeline perspective

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Bioactive compounds from cyanobacteria and microalgae: an overview

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Bioactive natural products from marine cyanobacteria for drug discovery

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Biosurfactants, bioemulsifiers and exopolysaccharides from marine microorganisms

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Methods for isolation of marine-derived endophytic fungi and their bioactive secondary products

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Chemical studies of marine bacteria: developing a new resource

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Marine Drugs from Sponge-Microbe Association—A Review

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Marine Biofilms as Mediators of Colonization by Marine Macroorganisms: Implications for Antifouling and Aquaculture

Qian, P., Lau, S. C. K., Dahms‬, H.-U., Dobretsov, S., & Harder, T. (2007) · Marine Biotechnology · doi:10.1007/s10126-007-9001-9 · Cited by 436 · see citing works

Production of microbial secondary metabolites: Regulation by the carbon source

Ruiz‐Villafán, B., Chávez, A., Forero, A. V. F., García-Huante, Y., Romero, A., Sánchez, M., Rocha-Mendoza, D., Sánchez, B., Rodrı́guez-Sanoja, R., Sánchez, S., et al. (2010) · Critical Reviews in Microbiology · doi:10.3109/10408410903489576 · Cited by 384 · see citing works

Bioactive Compound Synthetic Capacity and Ecological Significance of Marine Bacterial Genus Pseudoalteromonas

Bowman, J. P. (2007) · Marine Drugs · doi:10.3390/md504220 · Cited by 381 · see citing works

Bioactive metabolites of symbiotic marine microorganisms

Kobayashi, J., & Ishibashi, M. (1993) · Chemical Reviews · doi:10.1021/cr00021a005 · Cited by 369 · see citing works

Antitumor compounds from marine actinomycetes

Olano, C., Méndez, C., & Salas, J. A. (2009) · Marine Drugs · doi:10.3390/md7020210 · Cited by 330 · see citing works

Effect of phlorotannins isolated from Ecklonia cava on melanogenesis and their protective effect against photo-oxidative stress induced by UV-B radiation

Heo, S., Ko, S., Cha, S., Kang, D.-H., Park, H., Choi, Y., Kim, D., Jung, W., & Jeon, Y. (2009) · Toxicology in Vitro · doi:10.1016/j.tiv.2009.05.013 · Cited by 320 · see citing works

Natural Products from Marine Organisms and Their Associated Microbes

König, G. M., Kehraus, S., Seibert, S. F., Abdel‐Lateff, A., & Müller, D. (2005) · ChemBioChem · doi:10.1002/cbic.200500087 · Cited by 319 · see citing works

Improving production of bioactive secondary metabolites in actinomycetes by metabolic engineering

Olano, C., Lombó, F., Méndez, C., & Salas, J. A. (2008) · Metabolic Engineering · doi:10.1016/j.ymben.2008.07.001 · Cited by 299 · see citing works

Marine natural products

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A Fatty Acid from the Diatom Phaeodactylum tricornutum is Antibacterial Against Diverse Bacteria Including Multi-resistant Staphylococcus aureus (MRSA)

Desbois, A. P., Mearns-Spragg, A., & Smith, V. J. (2008) · Marine Biotechnology · doi:10.1007/s10126-008-9118-5 · Cited by 296 · see citing works

Marinomycins A−D, Antitumor-Antibiotics of a New Structure Class from a Marine Actinomycete of the Recently Discovered Genus “ Marinispora ”

Kwon, H. C., Kauffman, C. A., Jensen, P. R., & Fenical, W. (2006) · Journal of the American Chemical Society · doi:10.1021/ja0558948 · Cited by 294 · see citing works

MICROBIOLOGY TO 10,500 METERS IN THE DEEP SEA

Yayanos, A. A. (1995) · Annual Review of Microbiology · doi:10.1146/annurev.mi.49.100195.004021 · Cited by 294 · see citing works

Cyanobactins—ribosomal cyclic peptides produced by cyanobacteria

Sivonen, K., Leikoski, N., Fewer, D. P., & Jokela, J. (2010) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-010-2482-x · Cited by 275 · see citing works

Evidence for the Biosynthesis of Bryostatins by the Bacterial Symbiont “ Candidatus Endobugula sertula” of the Bryozoan Bugula neritina

Davidson, S. K., Allen, S. W., Lim, G. E., Anderson, C. M., & Haygood, M. G. (2001) · Applied and Environmental Microbiology · doi:10.1128/aem.67.10.4531-4537.2001 · Cited by 275 · see citing works

Prospective of the cosmeceuticals derived from marine organisms

Kim, S., Ravichandran, Y. D., Khan, S. B., & Kim, Y. T. (2008) · Biotechnology and Bioprocess Engineering · doi:10.1007/s12257-008-0113-5 · Cited by 267 · see citing works

Marine organisms as a source of new anticancer agents

Schwartsmann, G., da Rocha, A. B., Berlinck, R. G., & Jimeno, J. (2001) · The Lancet Oncology · doi:10.1016/s1470-2045(00)00292-8 · Cited by 261 · see citing works

The current status of natural products from marine fungi and their potential as anti-infective agents

Bhadury, P., Mohammad, B. T., & Wright, P. C. (2006) · Journal of Industrial Microbiology &amp; Biotechnology · doi:10.1007/s10295-005-0070-3 · Cited by 250 · see citing works

Calothrixins A and B, novel pentacyclic metabolites from Calothrix cyanobacteria with potent activity against malaria parasites and human cancer cells

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Exploring novel bioactive compounds from marine microbes

Zhang, L., An, R., Wang, J., Sun, N., Zhang, S., Hu, J., & Kuai, J. (2005) · Current Opinion in Microbiology · doi:10.1016/j.mib.2005.04.008 · Cited by 248 · see citing works

Marine Biofilm Bacteria Evade Eukaryotic Predation by Targeted Chemical Defense

Matz, C., Webb, J. S., Schupp, P. J., Phang, S. Y., Penesyan, A., Egan, S., Steinberg, P. D., & Kjelleberg, S. J. (2008) · PLoS ONE · doi:10.1371/journal.pone.0002744 · Cited by 227 · see citing works

Improved bioavailability and biodegradation of a model polyaromatic hydrocarbon by a biosurfactant producing bacterium of marine origin

Das, P., Mukherjee, S., & Sen, R. (2008) · Chemosphere · doi:10.1016/j.chemosphere.2008.05.015 · Cited by 215 · see citing works

Secondary metabolites from marine microorganisms

Kelecom, A. G. A. C. (2002) · Anais da Academia Brasileira de Ciências · doi:10.1590/s0001-37652002000100012 · Cited by 210 · see citing works

Secondary metabolites from marine microorganisms: bacteria, protozoa, algae and fungi. Achievements and prospects

Pietra, F. (1997) · Natural Product Reports · doi:10.1039/np9971400453 · Cited by 203 · see citing works

Marine Microorganisms as a Source of New Natural Products

Bernan, V., Greenstein, M. D., & Maiese, W. M. (1997) · Advances in applied microbiology · doi:10.1016/s0065-2164(08)70223-5 · Cited by 199 · see citing works

Marine Actinomycetes: A New Source of Compounds against the Human Malaria Parasite

Prudhomme, J. G., McDaniel, E., Ponts, N., Bertani, S., Fenical, W., Jensen, P. R., & Roch, K. G. L. (2008) · PLoS ONE · doi:10.1371/journal.pone.0002335 · Cited by 190 · see citing works

Optimization and production of novel antimicrobial agents from sponge associated marine actinomycetes Nocardiopsis dassonvillei MAD08

Selvin, J., Shanmughapriya, S., Gandhimathi, R., Kiran, G. S., Ravji, T. R., Natarajaseenivasan, K., & Hema, T. A. (2009) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-009-1878-y · Cited by 180 · see citing works

Bioactive natural products from blue-green algae

Patterson, G. M. L., Larsen, L. K., & Moore, R. E. (1994) · Journal of Applied Phycology · doi:10.1007/bf02186069 · Cited by 174 · see citing works

Potent antifouling compounds produced by marine Streptomyces

Xu, Y., He, H., Schulz, S., Liu, X., Fusetani, N., Xiong, H., Xiao, X. H., & Qian, P. (2009) · Bioresource Technology · doi:10.1016/j.biortech.2009.09.046 · Cited by 171 · see citing works

New dimensions in natural products research: Cultured marine microorganisms

Davidson, B. (1995) · Current Opinion in Biotechnology · doi:10.1016/0958-1669(95)80049-2 · Cited by 168 · see citing works

MC21-A, a Bactericidal Antibiotic Produced by a New Marine Bacterium, Pseudoalteromonas phenolica sp. nov. O-BC30 T , against Methicillin-Resistant Staphylococcus aureus

Isnansetyo, A., & Kamei, Y. (2003) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.47.2.480-488.2003 · Cited by 159 · see citing works

Anti-cancer and antibacterial trioxacarcins with high anti-malaria activity from a marine streptomycete and their absolute stereochemistry

MASKEY, R. P., HELMKE, E., KAYSER, O., FIEBIG, H. H., MAIER, A., BUSCHE, A., & LAATSCH, H. (2004) · The Journal of Antibiotics · doi:10.7164/antibiotics.57.771 · Cited by 158 · see citing works

Isolation of new actinomycete strains for the screening of new bioactive compounds.

Takahashi, Y. I., & Ōmura, S. (2003) · The Journal of General and Applied Microbiology · doi:10.2323/jgam.49.141 · Cited by 155 · see citing works

An exopolysaccharide produced by Geobacillus thermodenitrificans strain B3-72: Antiviral activity on immunocompetent cells

Arena, A., Gugliandolo, C., Stassi, G., Pavone, B., Iannello, D., Bisignano, G., & Maugeri, T. L. (2009) · Immunology Letters · doi:10.1016/j.imlet.2009.03.001 · Cited by 155 · see citing works

Lynamicins A−E, Chlorinated Bisindole Pyrrole Antibiotics from a Novel Marine Actinomycete

McArthur, K., Mitchell, S. S., Tsueng, G., Rheingold, A. L., White, D. J., Grodberg, J., Lam, K. S., & Potts, B. C. M. (2008) · Journal of Natural Products · doi:10.1021/np800286d · Cited by 151 · see citing works

Biosurfactant of marine origin exhibiting heavy metal remediation properties

Das, P., Mukherjee, S., & Sen, R. (2009) · Bioresource Technology · doi:10.1016/j.biortech.2009.05.028 · Cited by 151 · see citing works

New drugs from marine microbes: The tide is turning

Newman, D. J., & Hill, R. T. (2006) · Journal of Industrial Microbiology &amp; Biotechnology · doi:10.1007/s10295-006-0115-2 · Cited by 144 · see citing works

Epolactaene, a Novel Neuritogenic Compound in Human Neuroblastoma Cells, Produced by a Marine Fungus.

Kakeya, H., Takahashi, I., Okada, G., Isono, K., & Osada, H. (1995) · The Journal of Antibiotics · doi:10.7164/antibiotics.48.733 · Cited by 140 · see citing works

The Cyanobacterial Origin of Potent Anticancer Agents Originally Isolated from Sea Hares

Luesch, H., Harrigan, G. G., Goetz, G. H., & Horgen, F. D. (2002) · Current Medicinal Chemistry · doi:10.2174/0929867023369051 · Cited by 139 · see citing works

Viridamides A and B, Lipodepsipeptides with Antiprotozoal Activity from the Marine Cyanobacterium Oscillatoria nigro-viridis

Simmons, T. L., Engene, N., Urena, L. D., Romero, L. I., Ortega‐Barría, E., Gerwick, L. G., & Gerwick, W. H. (2008) · Journal of Natural Products · doi:10.1021/np800110e · Cited by 136 · see citing works

Correlation between pigmentation and antifouling compounds produced by Pseudoalteromonas tunicata

Egan, S., James, S., Holmström, C., & Kjelleberg, S. J. (2002) · Environmental Microbiology · doi:10.1046/j.1462-2920.2002.00322.x · Cited by 134 · see citing works

Fumiquinazolines, novel metabolites of a fungus isolated from a saltfish

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Medicinals for the Millennia

Cragg, G. M. L., & Newman, D. J. (2001) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2001.tb11356.x · Cited by 131 · see citing works

Marine Microorganisms and Drug Discovery: Current Status and Future Potential

Jensen, P. R., & Fenical, W. (2000) · KARGER eBooks · doi:10.1159/000062490 · Cited by 127 · see citing works

Octalactins A and B: cytotoxic eight-membered-ring lactones from a marine bacterium, Streptomyces sp

Tapiolas, D. M., Roman, M., Fenical, W., Stout, T. J., & Clardy, J. (1991) · Journal of the American Chemical Society · doi:10.1021/ja00012a048 · Cited by 126 · see citing works

Isolation, phylogenetic analysis and screening of marine mollusc-associated bacteria for antimicrobial, hemolytic and surface activities

Romanenko, L. A., Uchino, M., Kalinovskaya, N. I., & Mikhailov, V. V. (2008) · Microbiological Research · doi:10.1016/j.micres.2006.10.001 · Cited by 123 · see citing works

Salinamides A and B: anti-inflammatory depsipeptides from a marine streptomycete

Trischman, J. A., Tapiolas, D. M., Jensen, P. R., Dwight, R., Fenical, W., McKee, T. C., Ireland, C. M., Stout, T. J., & Clardy, J. (1994) · Journal of the American Chemical Society · doi:10.1021/ja00081a042 · Cited by 121 · see citing works

Lucentamycins A−D, Cytotoxic Peptides from the Marine-Derived Actinomycete <i>Nocardiopsis </i><i>lucentensis</i>

Cho, J. Y., Williams, P. G., Kwon, H. C., Jensen, P. R., & Fenical, W. (2007) · Journal of Natural Products · doi:10.1021/np070101b · Cited by 120 · see citing works

Mansouramycins A–D, cytotoxic isoquinolinequinones from a marine Streptomycete

Hawas, U. W., Shaaban, M., Shaaban, K. A., Speitling, M., Maier, A., Kelter, G., Fiebig, H. H., Meiners, M., Helmke, E., & Laatsch, H. (2009) · Journal of Natural Products · doi:10.1021/np900160g · Cited by 116 · see citing works

Isolation and Structure Elucidation of a Novel Yellow Pigment from the Marine Bacterium Pseudoalteromonas tunicata

Franks, A. E., Haywood, P. F., Holmström, C., Egan, S., Kjelleberg, S. J., & Kumar, N. (2005) · Molecules · doi:10.3390/10101286 · Cited by 116 · see citing works

New cytotoxic sesquiterpenoid nitrobenzoyl esters from a marine isolate of the fungus Aspergillus versicolor

Belofsky, G. N., Jensen, P. R., Renner, M. K., & Fenical, W. (1998) · Tetrahedron · doi:10.1016/s0040-4020(97)10396-9 · Cited by 113 · see citing works

Anti-photoaging activity and inhibition of matrix metalloproteinase (MMP) by marine red alga, Corallina pilulifera methanol extract

Ryu, B., Qian, Z.-J., Kim, M.-M., Nam, K. W., & Kim, S.-K. (2009) · Radiation Physics and Chemistry · doi:10.1016/j.radphyschem.2008.09.001 · Cited by 113 · see citing works

Novel Bioactive Metabolites from a Marine Derived Bacterium Nocardia sp. ALAA 2000

El-Gendy, M. M. A. A., Hawas, U. W., & Jaspars, M. (2008) · The Journal of Antibiotics · doi:10.1038/ja.2008.53 · Cited by 110 · see citing works

Marinone and debromomarinone: Antibiotic sesquiterpenoid naphthoquinones of a new structure class from a marine bacterium

Pathirana, C., Jensen, P. R., & Fenical, W. (1992) · Tetrahedron Letters · doi:10.1016/0040-4039(93)88010-g · Cited by 110 · see citing works

Halobacillin: A cytotoxic cyclic acylpeptide of the iturin class produced by a marine Bacillus

Trischman, J. A., Jensen, P. R., & Fenical, W. (1994) · Tetrahedron Letters · doi:10.1016/s0040-4039(00)77249-2 · Cited by 106 · see citing works

Alkaloids from a deep ocean sediment-derived fungus Penicillium sp. and their antitumor activities

Du, L., Feng, T., Zhao, B., Li, D., Cai, S., Zhu, T., Wang, F., Xiao, X., & Gu, Q. (2010) · The Journal of Antibiotics · doi:10.1038/ja.2010.11 · Cited by 106 · see citing works

Drugs from the Sea

(2000) · KARGER eBooks · doi:10.1159/isbn.978-3-318-00599-8 · Cited by 98 · see citing works

Antifungal Metabolites (Monorden, Monocillin IV, and Cerebrosides) from Humicola fuscoatra Traaen NRRL 22980, a Mycoparasite of Aspergillus flavus Sclerotia

Wicklow, D. T., Joshi, B. K., Gamble, W. R., Gloer, J. B., & Dowd, P. F. (1998) · Applied and Environmental Microbiology · doi:10.1128/aem.64.11.4482-4484.1998 · Cited by 96 · see citing works

Lodopyridone, a Structurally Unprecedented Alkaloid from a Marine Actinomycete

Maloney, K. N., MacMillan, J. B., Kauffman, C. A., Jensen, P. R., DiPasquale, A. G., Rheingold, A. L., & Fenical, W. (2009) · Organic Letters · doi:10.1021/ol901997k · Cited by 92 · see citing works

Isolation and Characterization of Tirandamycins from a Marine-Derived Streptomyces sp.

Carlson, J. C., Li, S., Burr, D. A., & Sherman, D. H. (2009) · Journal of Natural Products · doi:10.1021/np9005597 · Cited by 91 · see citing works

A New Antibacterial Dioxopiperazine Alkaloid Related to Gliotoxin from a Marine Isolate of the Fungus Pseudallescheria

Li, X., Kim, S., Nam, K. W., Kang, J. S., Choi, H. D., & Son, B. W. (2006) · The Journal of Antibiotics · doi:10.1038/ja.2006.35 · Cited by 90 · see citing works

Daryamides A−C, Weakly Cytotoxic Polyketides from a Marine-Derived Actinomycete of the Genus Streptomyces Strain CNQ-085

Asolkar, R. N., Jensen, P. R., Kauffman, C. A., & Fenical, W. (2006) · Journal of Natural Products · doi:10.1021/np0603828 · Cited by 89 · see citing works

Marine bacteria associated with marine macroorganisms: the potential antimicrobial resources

Zheng, L., Han, X., Chen, H., Lin, W., & Yan, X. (2005) · Annals of Microbiology · Cited by 89 · see citing works

Bioactive substances produced by marine isolates of Pseudomonas

Isnansetyo, A., & Kamei, Y. (2009) · Journal of Industrial Microbiology &amp; Biotechnology · doi:10.1007/s10295-009-0611-2 · Cited by 86 · see citing works

Aspergiolide A, a novel anthraquinone derivative with naphtho [1, 2, 3-de] chromene-2, 7-dione skeleton isolated from a marine-derived fungus Aspergillus glaucus

Du, L., Zhu, T., Fang, Y., Liu, H., Gu, Q., & Zhu, W. (2007) · Tetrahedron · doi:10.1016/j.tet.2006.11.074 · Cited by 84 · see citing works

Antimicrobial potential of sponge associated marine actinomycetes

Gandhimathi, R., Arunkumar, M., Selvin, J., Thangavelu, T., Sivaramakrishnan, S., Kiran, G. S., Shanmughapriya, S., & Natarajaseenivasan, K. (2008) · Journal de Mycologie Médicale · doi:10.1016/j.mycmed.2007.11.001 · Cited by 82 · see citing works

Phylogenetic Diversity and Antimicrobial Activities of Fungi Associated with Haliclona simulans Isolated from Irish Coastal Waters

Baker, P., Kennedy, J., Dobson, A. D. W., & Marchesi, J. R. (2008) · Marine Biotechnology · doi:10.1007/s10126-008-9169-7 · Cited by 81 · see citing works

New tamjamine class alkaloids from the marine ascidianAtapozoa sp. and its nudibranch predators. Origin of the tambjamines inAtapozoa

Lindquist, N., & Fenical, W. (1991) · Cellular and Molecular Life Sciences · doi:10.1007/bf01959957 · Cited by 78 · see citing works

Novel Antifouling and Antimicrobial Compound from a Marine-Derived Fungus Ampelomyces sp.

Kwong, T. F. N., Miao, L., Li, X., & Qian, P. (2006) · Marine Biotechnology · doi:10.1007/s10126-005-6146-2 · Cited by 77 · see citing works

Cytotoxic metabolites from a fungal adherent of a marine alga

Takahashi, C., Takai, Y., Kimura, Y., Numata, A., Shigematsu, N., & Tanaka, H. (1995) · Phytochemistry · doi:10.1016/0031-9422(94)00582-e · Cited by 76 · see citing works

Oxaline, a fungal alkaloid, arrests the cell cycle in M phase by inhibition of tubulin polymerization

Koizumi, Y., Arai, M., Tomoda, H., & Ōmura, S. (2004) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2004.04.013 · Cited by 75 · see citing works

Symbiotic Bacteria in Sponges: Sources of Bioactive Substances

Faulkner, D. J., Harper, M. K., Haygood, M. G., Salomon, C. E., & Schmidt, E. W. (2000) · KARGER eBooks · doi:10.1159/000062486 · Cited by 75 · see citing works

Resistoflavine, cytotoxic compound from a marine actinomycete, Streptomyces chibaensis AUBN1/7

Gorajana, A., Venkatesan, M., Vinjamuri, S., Kurada, B. V. V. S. N., Peela, S., Jangam, P., Ellaiah, P., & Zeeck, A. (2006) · Microbiological Research · doi:10.1016/j.micres.2006.01.012 · Cited by 74 · see citing works

The use of functional genomics for the identification of a gene cluster encoding for the biosynthesis of an antifungal tambjamine in the marine bacterium Pseudoalteromonas tunicata

Burke, C., Thomas, T., Egan, S., & Kjelleberg, S. J. (2006) · Environmental Microbiology · doi:10.1111/j.1462-2920.2006.01177.x · Cited by 73 · see citing works

Large-Scale Biotechnological Production of the Antileukemic Marine Natural Product Sorbicillactone A

Bringmann, G., Gulder, T. A. M., Lang, G., Schmitt, S., Stöhr, R., Wiese, J., Nagel, K., & Imhoff, J. F. (2007) · Marine Drugs · doi:10.3390/md502023 · Cited by 73 · see citing works

Low-Molecular-Weight, Biologically Active Compounds from Marine Pseudoalteromonas Species

Kalinovskaya, N. I., Ivanova, E. P., Alexeeva, Y. V., Gorshkova, N. M., Kuznetsova, T. A., Dmitrenok, A. S., & Nicolau, D. V. (2004) · Current Microbiology · doi:10.1007/s00284-003-4240-0 · Cited by 69 · see citing works

Novel Antifungal Diketopiperazine from Marine Fungus.

Byun, H., Zhang, H., MOCHIZUKI, M., Adachi, K., Shizuri, Y., LEE, W.-J., & Kim, S. (2003) · The Journal of Antibiotics · doi:10.7164/antibiotics.56.102 · Cited by 68 · see citing works

Alkaline Protease Gene Cloning from the Marine Yeast Aureobasidium pullulans HN2-3 and the Protease Surface Display on Yarrowia lipolytica for Bioactive Peptide Production

Ni, X., Yue, L., Chi, Z., Li, J., Wang, X., & Madzak, C. (2008) · Marine Biotechnology · doi:10.1007/s10126-008-9122-9 · Cited by 66 · see citing works

Lysis of methicillin-resistant Staphylococcus aureus by 2,4-diacetylphloroglucinol produced by Pseudomonas sp. AMSN isolated from a marine alga

Kamei, Y., & Isnansetyo, A. (2002) · International Journal of Antimicrobial Agents · doi:10.1016/s0924-8579(02)00251-0 · Cited by 66 · see citing works

Three New Indole‐Containing Diketopiperazine Alkaloids from a Deep‐Ocean Sediment Derived Fungus Penicillium griseofulvum

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Total Synthesis and Absolute Configuration of the Bisanthraquinone Antibiotic BE‐43472B

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