Cited by 59Microbial Natural Products and BiosynthesisMarine Sponges and Natural ProductsBioactive Natural Diterpenoids Research

Tartrolon D, a Cytotoxic Macrodiolide from the Marine-Derived Actinomycete Streptomyces sp. MDG-04-17-069

Pérez, Marta, Crespo, Cristina, Schleissner, Carmen, Rodríguez, Pilar, Zúñiga, Paz, Reyes, Fernando·2009·Journal of Natural Products

Abstract

Exploration of marine-derived actinomycetes as a source of antitumor compounds has led to the isolation of a new member of the tartrolon series, tartrolon D (4). This new compound was obtained from Streptomyces sp. MDG-04-17-069 fermentation broths and displayed strong cytotoxic activity against three human tumor cell lines. Additionally, the known compound ikarugamycin (5) was also found in the culture broths of the same microorganism. The structure of this new tartrolon was established by a combination of spectroscopic techniques (1D and 2D NMR, HRMS, and UV) as well as by comparison with published data for similar compounds.

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Crossref · 10.1021/np9006603

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18 of 18 references verified0 citation errors · 0 not checkable

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Authors
Pérez, M., Crespo, C., Schleissner, C., Rodríguez, P., Zúñiga, P., & Reyes, F.
Affiliations
PharmaMar (Spain) (ES)
Corresponding author
Reyes, Fernando
Venue
Journal of Natural Products
Published
2009-12-07
Volume
72
Issue
12
Pages
2192-2194
ISSN
  • 0163-3864 (ISSN-L)
  • 1520-6025
OpenAlex
W2004676756
Cited by
59
References
18
Citations by year
2026: 3 · 2025: 3 · 2024: 5 · 2023: 5 · 2022: 6 · 2021: 2 · 2020: 3 · 2019: 2 · 2018: 5 · 2017: 2 · 2016: 3 · 2015: 3 · 2014: 4 · 2013: 3 · 2012: 3
FWCI
2.16
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Natural Products (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Pharmacology › Microbial Natural Products and Biosynthesis
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Biotechnology › Marine Sponges and Natural Products
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bioactive Natural Diterpenoids Research
Keywords
Streptomyces, marine actinomycetes, cytotoxicity, anticancer agents, ikarugamycin, structure elucidation, natural product isolation, human cancer cell lines
MeSH terms
Antineoplastic Agents, Drug Screening Assays, Antitumor, Humans, Lactones, Marine Biology, Streptomyces, Molecular Structure, Nuclear Magnetic Resonance, Biomolecular

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