Tartrolon D, a Cytotoxic Macrodiolide from the Marine-Derived Actinomycete Streptomyces sp. MDG-04-17-069
Abstract
Exploration of marine-derived actinomycetes as a source of antitumor compounds has led to the isolation of a new member of the tartrolon series, tartrolon D (4). This new compound was obtained from Streptomyces sp. MDG-04-17-069 fermentation broths and displayed strong cytotoxic activity against three human tumor cell lines. Additionally, the known compound ikarugamycin (5) was also found in the culture broths of the same microorganism. The structure of this new tartrolon was established by a combination of spectroscopic techniques (1D and 2D NMR, HRMS, and UV) as well as by comparison with published data for similar compounds.
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- Authors
- Pérez, M., Crespo, C., Schleissner, C., Rodríguez, P., Zúñiga, P., & Reyes, F.
- Affiliations
- PharmaMar (Spain) (ES)
- Corresponding author
- Reyes, Fernando
- Venue
- Journal of Natural Products
- Publisher
- American Chemical Society (ACS)
- Published
- 2009-12-07
- Volume
- 72
- Issue
- 12
- Pages
- 2192-2194
- ISSN
- 0163-3864 (ISSN-L)
- 1520-6025
- OpenAlex
- W2004676756
- Cited by
- 59
- References
- 18
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 5 · 2023: 5 · 2022: 6 · 2021: 2 · 2020: 3 · 2019: 2 · 2018: 5 · 2017: 2 · 2016: 3 · 2015: 3 · 2014: 4 · 2013: 3 · 2012: 3
- FWCI
- 2.16
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Natural Products (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pharmacology › Microbial Natural Products and Biosynthesis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biotechnology › Marine Sponges and Natural Products
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bioactive Natural Diterpenoids Research
- Keywords
- Streptomyces, marine actinomycetes, cytotoxicity, anticancer agents, ikarugamycin, structure elucidation, natural product isolation, human cancer cell lines
- MeSH terms
- Antineoplastic Agents, Drug Screening Assays, Antitumor, Humans, Lactones, Marine Biology, Streptomyces, Molecular Structure, Nuclear Magnetic Resonance, Biomolecular
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