The DOI matches its Crossref record; 165 of the 165 references it cites were found in a registry or an index.
Hippurate: The Natural History of a Mammalian–Microbial Cometabolite
Abstract
Hippurate, the glycine conjugate of benzoic acid, is a normal constituent of the endogenous urinary metabolite profile and has long been associated with the microbial degradation of certain dietary components, hepatic function and toluene exposure, and is also commonly used as a measure of renal clearance. Here we discuss the potential relevance of hippurate excretion with regard to normal endogenous metabolism and trends in excretion relating to gender, age, and the intestinal microbiota. Additionally, the significance of hippurate excretion with respect to disease states including obesity, diabetes, gastrointestinal diseases, impaired renal function, psychological disorders and autism, as well as toxicity and parasitic infection, are considered.
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Self-citationGenome–microbiome interplay provides insight into the determinants of the human blood metabolome
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Metadata
- Authors
- Lees, H. J., Swann, J. R., Wilson, I. D., Nicholson, J. K., & Holmes, E.
- Venue
- Journal of Proteome Research
- Publisher
- American Chemical Society (ACS)
- Published
- 2013-03-06
- Volume
- 12
- Issue
- 4
- Pages
- 1527-1546
- ISSN
- 1535-3893 (ISSN-L)
- 1535-3907
- OpenAlex
- W1965809997
- Cited by
- 333
- References
- 165
- FWCI
- 8.47
- Type
- journal article
- Language
- en
- Open access
- closed
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- Lees, H. J., Swann, J. R., Wilson, I. D., Nicholson, J. K., & Holmes, E. (2013). Hippurate: The Natural History of a Mammalian–Microbial Cometabolite. Journal of Proteome Research. https://doi.org/10.1021/pr300900b
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