Cited by 65Gut microbiota and healthDietary Effects on HealthAnimal Nutrition and Physiology

Calorie restriction and its impact on gut microbial composition and global metabolism

Open access
Zheng, Xiaojiao, Wang, Shouli, Jia, Wei·2018·Frontiers of Medicine

Abstract

Calorie restriction (CR) is a dietary regimen that reduces calorie intake without incurring malnutrition or a reduction in essential nutrients. It has long been recognized as a natural strategy for promoting health, extending longevity, and prevents the development of metabolic and age-related diseases. In the present review, we focus on the general effect of CR on gut microbiota composition and global metabolism. We also propose mechanisms for its beneficial effect. Results showed that probiotic and butyrate-producing microbes increased their relative abundance, whereas proinflammatory strains exhibited suppressed relative abundance following CR. Analyses of the gut microbial and host metabolisms revealed that most host microbial co-metabolites were changed due to CR. Examples of dramatic CR-induced changes in host metabolism included a decrease in the rate of lipid biosynthesis and an increase in the rates of fatty acid catabolism, β-oxidation, glycogenolysis, and gluconeogenesis. The observed phenotypes and the further verification of the direct link between gut microbiota and metabolome may benefit patients that are at risk for developing metabolic disease. Thus, improved gut microbiota composition and metabolome are potential biomarkers for determining the effectiveness of dietary interventions for age-related and metabolic diseases.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1007/s11684-018-0670-8

Cites

112 of 112 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Calorie restriction, primarily in animals, can improve the composition and associated metabolism of the gut microbiota, including increasing the relative abundances of probiotic and butyrate-producing microbes and increasing SCFA biosynthesis.

    “Calorie restriction, primarily in animals, can improve the composition and associated metabolism of the gut microbiota, including increasing the relative abundances of probiotic and butyrate-producing microbes [159] and increasing SCFA biosynthesis [160].”

    From The athletic gut microbiota (2020) · cites this paper as [159]

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Zheng, X., Wang, S., & Jia, W.
Affiliations
Shanghai Jiao Tong University (CN)
Corresponding author
Jia, Wei
Venue
Frontiers of Medicine
Published
2018-11-16
Volume
12
Issue
6
Pages
634-644
ISSN
  • 1673-7342 (ISSN-L)
  • 2095-0217
  • 2095-0225
OpenAlex
W2900705152
Cited by
65
References
112
Citations by year
2026: 5 · 2025: 5 · 2024: 8 · 2023: 9 · 2022: 8 · 2021: 14 · 2020: 11 · 2019: 4 · 2018: 1
FWCI
0.74
Type
journal article
Language
en
Open access
Locations
  • Frontiers of Medicine (publishedVersion, cc-by)
  • PubMed (publishedVersion)
Funders
National Natural Science Foundation of China (31500954)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
  • Health Sciences › Medicine › Physiology › Dietary Effects on Health
  • Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Animal Nutrition and Physiology
Keywords
caloric restriction, gut microbiota, host metabolism, microbial metabolites, probiotics, butyrate-producing bacteria, pro-inflammatory bacteria, lipogenesis, fatty acid beta-oxidation, gluconeogenesis, glycogenolysis, aging, metabolic disorders, dietary intervention, biomarkers
MeSH terms
Gastrointestinal Microbiome, Animals, Bacteroides, Humans, Metabolic Diseases, Caloric Restriction, Bacteroidetes, Gastrointestinal Tract, Metabolome

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review