Calorie restriction and its impact on gut microbial composition and global metabolism
Open accessAbstract
Calorie restriction (CR) is a dietary regimen that reduces calorie intake without incurring malnutrition or a reduction in essential nutrients. It has long been recognized as a natural strategy for promoting health, extending longevity, and prevents the development of metabolic and age-related diseases. In the present review, we focus on the general effect of CR on gut microbiota composition and global metabolism. We also propose mechanisms for its beneficial effect. Results showed that probiotic and butyrate-producing microbes increased their relative abundance, whereas proinflammatory strains exhibited suppressed relative abundance following CR. Analyses of the gut microbial and host metabolisms revealed that most host microbial co-metabolites were changed due to CR. Examples of dramatic CR-induced changes in host metabolism included a decrease in the rate of lipid biosynthesis and an increase in the rates of fatty acid catabolism, β-oxidation, glycogenolysis, and gluconeogenesis. The observed phenotypes and the further verification of the direct link between gut microbiota and metabolome may benefit patients that are at risk for developing metabolic disease. Thus, improved gut microbiota composition and metabolome are potential biomarkers for determining the effectiveness of dietary interventions for age-related and metabolic diseases.
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Calorie restriction, primarily in animals, can improve the composition and associated metabolism of the gut microbiota, including increasing the relative abundances of probiotic and butyrate-producing microbes and increasing SCFA biosynthesis.
“Calorie restriction, primarily in animals, can improve the composition and associated metabolism of the gut microbiota, including increasing the relative abundances of probiotic and butyrate-producing microbes [159] and increasing SCFA biosynthesis [160].”
From The athletic gut microbiota (2020) · cites this paper as [159]
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Mohr, A. E., Jäger, R., Carpenter, K. C., Kerksick, C. M., Purpura, M., Townsend, J. R., West, N. P., Black, K., Gleeson, M., Pyne, D. B., et al. (2020) · Journal of the International Society of Sports Nutrition · doi:10.1186/s12970-020-00353-w · Cited by 378 · see citing works
“producing microbes [159] and increasing SCFA biosynthesis [160].”
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Self-citation
- Authors
- Zheng, X., Wang, S., & Jia, W.
- Affiliations
- Shanghai Jiao Tong University (CN)
- Corresponding author
- Jia, Wei
- Venue
- Frontiers of Medicine
- Published
- 2018-11-16
- Volume
- 12
- Issue
- 6
- Pages
- 634-644
- ISSN
- 1673-7342 (ISSN-L)
- 2095-0217
- 2095-0225
- OpenAlex
- W2900705152
- Cited by
- 65
- References
- 112
- Citations by year
- 2026: 5 · 2025: 5 · 2024: 8 · 2023: 9 · 2022: 8 · 2021: 14 · 2020: 11 · 2019: 4 · 2018: 1
- FWCI
- 0.74
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Frontiers of Medicine (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (31500954)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Physiology › Dietary Effects on Health
- Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Animal Nutrition and Physiology
- Keywords
- caloric restriction, gut microbiota, host metabolism, microbial metabolites, probiotics, butyrate-producing bacteria, pro-inflammatory bacteria, lipogenesis, fatty acid beta-oxidation, gluconeogenesis, glycogenolysis, aging, metabolic disorders, dietary intervention, biomarkers
- MeSH terms
- Gastrointestinal Microbiome, Animals, Bacteroides, Humans, Metabolic Diseases, Caloric Restriction, Bacteroidetes, Gastrointestinal Tract, Metabolome
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