Contributions of Human Enzymes in Carcinogen Metabolism

Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians

Shimada, T., Yamazaki, H., Mimura, M., Inui, Y., & Guengerich, F. P. (1994) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)22379-5 · Cited by 2,785

Pharmacogenomics: Translating Functional Genomics into Rational Therapeutics

Evans, W. E., & Relling, M. V. (1999) · Science · doi:10.1126/science.286.5439.487 · Cited by 2,475

Carcinogens are Mutagens: A Simple Test System Combining Liver Homogenates for Activation and Bacteria for Detection

Ames, B. N., Durston, W. E., Yamasaki, E., & Lee, F. D. (1973) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.70.8.2281 · Cited by 2,276

Substrate-inducible Microsomal Aryl Hydroxylase in Mammalian Cell Culture

Nebert, D. W., & Gelboin, H. V. (1968) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)94484-4 · Cited by 1,676

Induction of microsomal enzymes by foreign chemicals and carcinogenesis by polycyclic aromatic hydrocarbons: G. H. A. Clowes Memorial Lecture.

Conney, A. H. (1982) · PubMed · Cited by 1,557

Carcinogenesis by chemicals: an overview--G. H. A. Clowes memorial lecture.

MILLER, J. A. (1970) · PubMed · Cited by 1,450

Role of human cytochrome P-450 IIE1 in the oxidation of many low molecular weight cancer suspects

Guengerich, F. P., Kim, D. H., & Iwasaki, M. (1991) · Chemical Research in Toxicology · doi:10.1021/tx00020a008 · Cited by 1,169

Oxidation of toxic and carcinogenic chemicals by human cytochrome P-450 enzymes

Guengerich, F. P., & Shimada, T. (1991) · Chemical Research in Toxicology · doi:10.1021/tx00022a001 · Cited by 1,000

Human cytochrome P450 enzymes: a status report summarizing their reactions, substrates, inducers, and inhibitors

Rendic, S., & Carlo, F. J. D. (1997) · Drug Metabolism Reviews · doi:10.3109/03602539709037591 · Cited by 949

DRUG-DRUG INTERACTIONS FOR UDP-GLUCURONOSYLTRANSFERASE SUBSTRATES: A PHARMACOKINETIC EXPLANATION FOR TYPICALLY OBSERVED LOW EXPOSURE (AUCI/AUC) RATIOS

Williams, J. A., Hyland, R., Jones, B. C., Smith, D. A., Hurst, S., Goosen, T. C., Peterkin, V., Koup, J. R., & Ball, S. E. (2004) · Drug Metabolism and Disposition · doi:10.1124/dmd.104.000794 · Cited by 928

Predicting in vivo drug interactions from in vitro drug discovery data

Wienkers, L. C., & Heath, T. G. (2005) · Nature Reviews Drug Discovery · doi:10.1038/nrd1851 · Cited by 904

Summary of information on human CYP enzymes: human P450 metabolism data

Rendic, S. (2002) · Drug Metabolism Reviews · doi:10.1081/dmr-120001392 · Cited by 820

Metabolic activation of polycyclic aromatic hydrocarbons to carcinogens by cytochromes P450 1A1 and1B1

Shimada, T., & Fujii‐Kuriyama, Y. (2004) · Cancer Science · doi:10.1111/j.1349-7006.2004.tb03162.x · Cited by 804

Activation of chemically diverse procarcinogens by human cytochrome P-450 1B1.

Shimada, T., Hayes, C. L., Yamazaki, H., et al. (1996) · PubMed · Cited by 793

Human Cytochrome P450 Enzymes

Guengerich, F. P. (1995) · Cytochrome P450 · doi:10.1007/978-1-4757-2391-5_14 · Cited by 728

Characterization of the common genetic defect in humans deficient in debrisoquine metabolism

Gonzalez, F. J., Skodat, R. C., Kimura, S., Umeno, M., Zanger, U. M., Nebert, D. W., Gelboin, H. V., Hardwick, J. P., & Meyer, U. A. (1988) · Nature · doi:10.1038/331442a0 · Cited by 715

Comprehensive Evaluation of Tamoxifen Sequential Biotransformation by the Human Cytochrome P450 System in Vitro: Prominent Roles for CYP3A and CYP2D6

Desta, Z., Ward, B. A., Soukhova, N. V., & Flockhart, D. A. (2004) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.104.065607 · Cited by 645

Human cytochrome P-450PA (P-450IA2), the phenacetin O-deethylase, is primarily responsible for the hepatic 3-demethylation of caffeine and N-oxidation of carcinogenic arylamines.

Butler, M. A., Iwasaki, M., Guengerich, F. P., & Kadlubar, F. F. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.20.7696 · Cited by 638

17 beta-estradiol hydroxylation catalyzed by human cytochrome P450 1B1.

Hayes, C. L., Spink, D. C., Spink, B. C., Cao, J. Q., Walker, N. J., & Sutter, T. R. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.18.9776 · Cited by 632

Cytochrome P450-mediated metabolism of estrogens and its regulation in human

Tsuchiya, Y., Nakajima, M., & Yokoi, T. (2005) · Cancer Letters · doi:10.1016/j.canlet.2004.10.007 · Cited by 616

Xenobiotic-Metabolizing Enzymes Involved in Activation and Detoxification of Carcinogenic Polycyclic Aromatic Hydrocarbons

Shimada, T. (2006) · Drug Metabolism and Pharmacokinetics · doi:10.2133/dmpk.21.257 · Cited by 606

Aryl Hydrocarbon Hydroxylase Inducibility and Bronchogenic Carcinoma

Kellermann, G., Shaw, C. R., & Luyten-Kellerman, M. (1973) · New England Journal of Medicine · doi:10.1056/nejm197311012891802 · Cited by 591

Differential activation of cyclophosphamide and ifosphamide by cytochromes P-450 2B and 3A in human liver microsomes.

Chang, T. K. H., Weber, G. F., Crespi, C. L., & Waxman, D. J. (1993) · PubMed · Cited by 545

Role of Human Cytochromes P450 in the Metabolic Activation of Chemical Carcinogens and Toxins

Gonzalez, F. J., & Gelboin, H. V. (1994) · Drug Metabolism Reviews · doi:10.3109/03602539409029789 · Cited by 493

Normal Chest Roentgenograms in Chronic Diffuse Infiltrative Lung Disease

Epler, G., McLoud, T. C., Gaensler, E. A., et al. (1978) · New England Journal of Medicine · doi:10.1056/nejm197804272981703 · Cited by 483

Inhibition of neoplasia by minor dietary constituents.

Lw, W. (1983) · PubMed · Cited by 473

Comparative metabolic capabilities of CYP3A4, CYP3A5, and CYP3A7

Williams, J. A., Ring, B. J., Cantrell, V. E., Jones, D. R., Eckstein, J., Ruterbories, K., Hamman, M. A., Hall, S. D., & Wrighton, S. A. (2002) · Drug Metabolism and Disposition · doi:10.1124/dmd.30.8.883 · Cited by 471

Characterization of the Oxidative Metabolites of 17β-Estradiol and Estrone Formed by 15 Selectively Expressed Human Cytochrome P450 Isoforms

Lee, A. J., Cai, M. X., Thomas, P. E., Conney, A. H., & Zhu, B. T. (2003) · Endocrinology · doi:10.1210/en.2003-0192 · Cited by 456

Roles of cytochrome P-450 enzymes in chemical carcinogenesis and cancer chemotherapy.

Guengerich, F. P. (1988) · PubMed · Cited by 455

Determination of CYP1A2 and NAT2 phenotypes in human populations by analysis of caffeine urinary metabolites

Butler, M. A., Lang, N. P., Young, J. F., Caporaso, N. E., Vineis, P., Hayes, R. B., Teitel, C. H., Massengill, J. P., Lawsen, M. F., & Kadlubar, F. F. (1992) · Pharmacogenetics · doi:10.1097/00008571-199206000-00003 · Cited by 419

Cytochrome P450 2E1 and 2A6 enzymes as major catalysts for metabolic activation of N-nitrosodialkylamines and tobacco-related nitrosamines in human liver microsomes

Yamazaki, H., Inui, Y., Yun, C.-H., Guengerich, F. P., & Shimada, T. (1992) · Carcinogenesis · doi:10.1093/carcin/13.10.1789 · Cited by 398

Separation and purification of multiple forms of microsomal cytochrome P-450. Activities of different forms of cytochrome P-450 towards several compounds of environmental interest.

Guengerich, F. P. (1977) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)40345-0 · Cited by 366

Metabolic activation and deactivation of arylamine carcinogens by recombinant human NAT1 and polymorphic NAT2 acetyltransferases

Hein, D. W., Doll, M. A., Rustan, T. D., Gray, K., Feng, Y., Ferguson, R. J., & Grant, D. M. (1993) · Carcinogenesis · doi:10.1093/carcin/14.8.1633 · Cited by 359

Sulfotransferases in the bioactivation of xenobiotics

Glatt, H. (2000) · Chemico-Biological Interactions · doi:10.1016/s0009-2797(00)00202-7 · Cited by 354

Activation and detoxication of aflatoxin B1

Guengerich, F. P., Johnson, W. W., Shimada, T., Ueng, Y.-F., Yamazaki, H., & Langouët, S. (1998) · Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis · doi:10.1016/s0027-5107(97)00289-3 · Cited by 344

Human cytochrome P450 CYP2A13: predominant expression in the respiratory tract and its high efficiency metabolic activation of a tobacco-specific carcinogen, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone.

Su, T., Bao, Z., Zhang, Q., Smith, T. J., Hong, J., & Ding, X. (2000) · PubMed · Cited by 339

Development of a Substrate-Activity Based Approach To Identify the Major Human Liver P-450 Catalysts of Cyclophosphamide and Ifosfamide Activation Based on cDNA-Expressed Activities and Liver Microsomal P-450 Profiles

Roy, P., Yu, L. J., Crespi, C. L., & Waxman, D. J. (1999) · Drug Metabolism and Disposition · doi:10.1016/s0090-9556(24)15302-0 · Cited by 320

Purification and characterization of the human liver cytochromes P-450 involved in debrisoquine 4-hydroxylation and phenacetin O-deethylation, two prototypes for genetic polymorphism in oxidative drug metabolism.

Distlerath, L. M., Reilly, P. E., Martin, M. V., Davis, G. G., Wilkinson, G. R., & Guengerich, F. P. (1985) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)39456-5 · Cited by 319

The Presence and Significance of Bound Aminoazo Dyes in the Livers of Rats Fed p-Dimethylaminoazobenzene

Miller, E. C., & MILLER, J. A. (1947) · Cancer Research · Cited by 318

Differences in the catalytic efficiencies of allelic variants of glutathione transferase P1-1 towards carcinogenic diol epoxides of polycyclic aromatic hydrocarbons

Sundberg, K. (1998) · Carcinogenesis · doi:10.1093/carcin/19.3.433 · Cited by 318

Cytochrome P450 1B1 (CYP1B1) pharmacogenetics: association of polymorphisms with functional differences in estrogen hydroxylation activity.

Hanna, I. H., Dawling, S., Roodi, N., Guengerich, F. P., & Parl, F. F. (2000) · PubMed · Cited by 306

106. The isolation of a cancer-producing hydrocarbon from coal tar. Parts I, II, and III

Cook, J. W., Hewett, C. L., & Hieger, I. (1933) · Journal of the Chemical Society (Resumed) · doi:10.1039/jr9330000395 · Cited by 304

Evidence for cytochrome P-450NF, the nifedipine oxidase, being the principal enzyme involved in the bioactivation of aflatoxins in human liver.

Shimada, T., & Guengerich, F. P. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.2.462 · Cited by 299

Metabolism of benzo[a]pyrene and benzo[a]pyrene-7,8-diol by human cytochrome P450 1B1

Kim, J. (1998) · Carcinogenesis · doi:10.1093/carcin/19.10.1847 · Cited by 286

Metabolism of trichloroethylene.

Lash, L. H., Fisher, J. W., Lipscomb, J. C., & Parker, J. C. (2000) · Environmental Health Perspectives · doi:10.1289/ehp.00108s2177 · Cited by 284

Flavonoids and alkenylbenzenes: Mechanisms of mutagenic action and carcinogenic risk

Rietjens, I. M. C. M., Boersma, M. G., van der Woude, H., Jeurissen, S. M. F., Schutte, M. E., & Alink, G. M. (2005) · Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis · doi:10.1016/j.mrfmmm.2005.01.028 · Cited by 281

Sudan I is a potential carcinogen for humans: evidence for its metabolic activation and detoxication by human recombinant cytochrome P450 1A1 and liver microsomes.

Stiborová, M., Martínek, V., Rýdlová, H., Hodek, P., & Frei, E. (2002) · PubMed · Cited by 274

Catalytic properties of polymorphic human cytochrome P450 1B1 variants

Shimada, T. (1999) · Carcinogenesis · doi:10.1093/carcin/20.8.1607 · Cited by 270

Human aldo–keto reductases: Function, gene regulation, and single nucleotide polymorphisms

Penning, T. M., & Drury, J. E. (2007) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2007.04.024 · Cited by 266

Human liver microsomal cytochrome P-450 enzymes involved in the bioactivation of procarcinogens detected by umu gene response in Salmonella typhimurium TA 1535/pSK1002.

Shimada, T., Iwasaki, M., Martin, M. V., & Guengerich, F. P. (1989) · PubMed · Cited by 265

Purification and Characterization of Human Liver Microsomal Cytochrome P-450 2A6

Yun, C.-H., Shimada, T., & Guengerich, F. P. (1991) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)15384-4 · Cited by 265

Bioactivation of Halogenated Hydrocarbons by Cytochrome P4502E1

Raucy, J. L., Kraner, J. C., & Lasker, J. M. (1993) · Critical Reviews in Toxicology · doi:10.3109/10408449309104072 · Cited by 265

Role of human liver microsomal CYP3A4 and CYP2B6 in catalyzing N-dechloroethylation of cyclophosphamide and ifosfamide

Huang, Z., Roy, P., & Waxman, D. J. (2000) · Biochemical Pharmacology · doi:10.1016/s0006-2952(99)00410-4 · Cited by 263

Activation of procarcinogens by human cytochrome P450 enzymes

Peter Guengerich, F., & Shimada, T. (1998) · Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis · doi:10.1016/s0027-5107(98)00037-2 · Cited by 260

Human cytosolic sulphotransferases: genetics, characteristics, toxicological aspects

Glatt, H., Boeing, H., Engelke, C. E. H., Ma, L., Kuhlow, A., Pabel, U., Pomplun, D., Teubner, W., & Meinl, W. (2001) · Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis · doi:10.1016/s0027-5107(01)00207-x · Cited by 245

Human cytochrome P4502B6: interindividual hepatic expression, substrate specificity, and role in procarcinogen activation.

Code, E. L., Crespi, C. L., Penman, B. W., Gonzalez, F. J., Chang, T. K. H., & Waxman, D. J. (1997) · PubMed · Cited by 245

Metabolism of Tamoxifen by Recombinant Human Cytochrome P450 Enzymes: Formation of the 4-Hydroxy, 4′-Hydroxy and N-Desmethyl Metabolites and Isomerization of trans-4-Hydroxytamoxifen

Crewe, H. K., Notley, L. M., Wunsch, R. M., Lennard, M. S., & Gillam, E. M. J. (2002) · Drug Metabolism and Disposition · doi:10.1124/dmd.30.8.869 · Cited by 241

Stable expression of human cytochrome P4502E1 in HepG2 cells: Characterization of catalytic activities and production of reactive oxygen intermediates

Dai, Y., Rashba-Step, J., & Cederbaum, A. I. (1993) · Biochemistry · doi:10.1021/bi00078a017 · Cited by 240

Stimulatory effect of brussels sprouts and cabbage on human drug metabolism

Pantuck, E. J., Pantuck, C. B., Garland, W. A., Min, B. H., Wattenberg, L. W., Anderson, K. E., Kappas, A., & Conney, A. H. (1979) · Clinical Pharmacology & Therapeutics · doi:10.1002/cpt197925188 · Cited by 239

Five of 12 forms of vaccinia virus-expressed human hepatic cytochrome P450 metabolically activate aflatoxin B1.

Aoyama, T., Yamano, S., Guzelian, P. S., Gelboin, H. V., & Gonzalez, F. J. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.12.4790 · Cited by 235

A tobacco smoke-derived nitrosamine, 4-(methytnitrosamino)-1-(3-pyridyl)-1-butanone, is activated by multiple human cytocbrome P450s including the polymorphic human cytochrome P4502D6

Crespi, C. L., Penman, B. W., Gelboin, H. V., & Gonzalez, F. J. (1991) · Carcinogenesis · doi:10.1093/carcin/12.7.1197 · Cited by 235

Xenobiotic-metabolizing cytochrome P450 enzymes in the human feto-placental unit: role in intrauterine toxicity

Hakkola, J., Pelkonen, O., Pasanen, M., & Raunio, H. (1998) · Critical Reviews in Toxicology · doi:10.1080/10408449891344173 · Cited by 229

Metabolic activation of polycyclic aromatic hydrocarbons and other procarcinogens by cytochromes P450 1A1 and P450 1B1 allelic variants and other human cytochromes P450 in Salmonella typhimurium NM2009.

Shimada, T., Oda, Y., Gillam, E. M. J., Guengerich, F. P., & Inoue, K. (2001) · PubMed · Cited by 225

Role of human microsomal and human complementary DNA-expressed cytochromes P4501A2 and P4503A4 in the bioactivation of aflatoxin B1.

Gallagher, E. P., Wienkers, L. C., Stapleton, P. L., Kunze, K. L., & Eaton, D. L. (1994) · PubMed · Cited by 223

Activation of Polycyclic Aromatic Hydrocarbontrans-Dihydrodiol Proximate Carcinogens by Human Aldo-keto Reductase (AKR1C) Enzymes and Their Functional Overexpression in Human Lung Carcinoma (A549) Cells

Palackal, N. T., Lee, S. H., Harvey, R. G., Blair, I. A., & Penning, T. M. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m112424200 · Cited by 222

Roles of individual human cytochrome P-450 enzymes in the bioactivation of benzo(a)pyrene, 7,8-dihydroxy-7,8-dihydrobenzo(a)pyrene, and other dihydrodiol derivatives of polycyclic aromatic hydrocarbons.

Shimada, T., Mv, M., Pruess-Schwartz, D., Marnett, L. J., & Guengerich, F. P. (1989) · PubMed · Cited by 222

Human Cytochrome P450 Enzymes

Guengerich, F. P. (2007) · Cytochrome P450 · doi:10.1007/0-387-27447-2_10 · Cited by 220

Elucidation of Distinct Ligand Binding Sites for Cytochrome P450 3A4

Hosea, N. A., Miller, G. P., & Guengerich, F. P. (2000) · Biochemistry · doi:10.1021/bi992765t · Cited by 219

Oxidation of Aflatoxin B1 by Bacterial Recombinant Human Cytochrome P450 Enzymes

Ueng, Y.-F., Shimada, T., Yamazaki, H., & Guengerich, F. P. (1995) · Chemical Research in Toxicology · doi:10.1021/tx00044a006 · Cited by 216

Oxidation of Benzo[a]pyrene by Recombinant Human Cytochrome P450 Enzymes

Bauer, E., Guo, Z., Ueng, Y.-F., Bell, L. C., Zeldin, D., & Guengerich, F. P. (1995) · Chemical Research in Toxicology · doi:10.1021/tx00043a018 · Cited by 212

4-Hydroxylation of estradiol by human uterine myometrium and myoma microsomes: implications for the mechanism of uterine tumorigenesis.

Liehr, J. G., Ricci, M. J., Jefcoate, C. R., Hannigan, E. V., Hokanson, J. A., & Zhu, B. T. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.20.9220 · Cited by 208

Cisplatin-Induced Hepatotoxicity Is Enhanced by Elevated Expression of Cytochrome P450 2E1

Lu, Y., & Cederbaum, A. I. (2006) · Toxicological Sciences · doi:10.1093/toxsci/kfj031 · Cited by 202

Bioactivation of mutagens via sulfation

Glatt, H. (1997) · The FASEB Journal · doi:10.1096/fasebj.11.5.9141497 · Cited by 200

The effects of 2,3,7,8-Tetrachlorodibenzo-p-dioxin on estrogen metabolism in MCF-7 breast cancer cells: Evidence for induction of a novel 17β-estradiol 4-hydroxylase

Spink, D. C., Hayes, C. L., Young, N. R., Christou, M., Sutter, T. R., Jefcoate, C. R., & Gierthy, J. F. (1994) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/0960-0760(94)90037-x · Cited by 195

Isoform-specific induction of a human aldo-keto reductase by polycyclic aromatic hydrocarbons (PAHs), electrophiles, and oxidative stress: implications for the alternative pathway of PAH activation catalyzed by human dihydrodiol dehydrogenase.

Burczynski, M. E., Hseuh-Kung, L. I. N., & Penning, T. M. (1999) · PubMed · Cited by 191

The Reactive Oxygen Species- and Michael Acceptor-inducible Human Aldo-Keto Reductase AKR1C1 Reduces the α,β-Unsaturated Aldehyde 4-Hydroxy-2-nonenal to 1,4-Dihydroxy-2-nonene

Burczynski, M. E., Sridhar, G. R., Palackal, N. T., & Penning, T. M. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m006655200 · Cited by 190

Expression of mammalian glutathione S-transferase 5-5 in Salmonella typhimurium TA1535 leads to base-pair mutations upon exposure to dihalomethanes.

Thier, R., Taylor, J. B., Pemble, S. E., Humphreys, W. G., Persmark, M., Ketterer, B., & Guengerich, F. P. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.18.8576 · Cited by 188

Inhibition of Human Cytochrome P450 1A1-, 1A2-, and 1B1-Mediated Activation of Procarcinogens to Genotoxic Metabolites by Polycyclic Aromatic Hydrocarbons

Shimada, T., & Guengerich, F. P. (2006) · Chemical Research in Toxicology · doi:10.1021/tx050291v · Cited by 185

Role of human cytochrome P450 1A1, 1A2, 1B1, and 3A4 in the 2-, 4-, and 16[alpha ]-hydroxylation of 17[beta ]-estradiol

Badawi, A. F., Cavalieri, E. L., & Rogan, E. G. (2001) · Metabolism · doi:10.1053/meta.2001.25592 · Cited by 184

Roles of Cytochromes P450 1A2 and 3A4 in the Oxidation of Estradiol and Estrone in Human Liver Microsomes

Yamazaki, H., Shaw, P. M., Guengerich, F. P., & Shimada, T. (1998) · Chemical Research in Toxicology · doi:10.1021/tx970217f · Cited by 182

CYP1A1 and GSTM1 genotypes affect benzo[a]pyrene DNA adducts in smokers' lung: comparison with aromatic/hydrophobic adduct formation

Alexandrov, K. (2002) · Carcinogenesis · doi:10.1093/carcin/23.12.1969 · Cited by 182

THE ROLE OF CYP2B6 IN HUMAN XENOBIOTIC METABOLISM*

EKINS, S., & WRIGHTON, S. A. (1999) · Drug Metabolism Reviews · doi:10.1081/dmr-100101942 · Cited by 176

DNA Adduction by the Potent Carcinogen Aflatoxin B1: Mechanistic Studies

Iyer, R. S., Coles, B. F., Raney, K. D., Thier, R., Guengerich, F. P., & Harris, T. M. (1994) · Journal of the American Chemical Society · doi:10.1021/ja00084a001 · Cited by 175

Activation of Heterocyclic Aromatic Amines by Rat and Human Liver Microsomes and by Purified Rat and Human Cytochrome P450 1A2

Turesky, R. J., Constable, A., Richoz, J., Varga, N., Markovic, J., Martin, M. V., & Guengerich, F. P. (1998) · Chemical Research in Toxicology · doi:10.1021/tx980022n · Cited by 170

Activity of Four Allelic Forms of Glutathione S-Transferase hGSTP1-1 for Diol Epoxides of Polycyclic Aromatic Hydrocarbons

Hu, X., Xia, H., Srivastava, S. K., Herzog, C., Awasthi, Y. C., Ji, X., Zimniak, P., & Singh, S. V. (1997) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1997.7311 · Cited by 167

The role of 12 cDNA‐expressed human, rodent, and rabbit cytochromes P450 in the metabolism of benzo[a]pyrene and benzo[a]pyrene trans‐7, 8‐dihydrodiol

Shou, M., Korzekwa, K. R., Crespi, C. L., Gonzalez, F. J., & Gelboin, H. V. (1994) · Molecular Carcinogenesis · doi:10.1002/mc.2940100307 · Cited by 167

THE CYP2E1-HUMANIZED TRANSGENIC MOUSE: ROLE OF CYP2E1 IN ACETAMINOPHEN HEPATOTOXICITY

Cheung, C., Yu, A.-M., Ward, J. M., Krausz, K. W., Akiyama, T. E., Feigenbaum, L., & Gonzalez, F. J. (2005) · Drug Metabolism and Disposition · doi:10.1124/dmd.104.002402 · Cited by 167

Oxidation of xenobiotics by recombinant human cytochrome P450 1B1.

Shimada, T., Gillam, E. M. J., Sutter, T. R., Strickland, P. T., Guengerich, F. P., & Yamazaki, H. (1997) · PubMed · Cited by 166

Carcinogen substrate specificity of human COX-1 and COX-2

Wiese, F. W. (2001) · Carcinogenesis · doi:10.1093/carcin/22.1.5 · Cited by 164

Involvement of human glutathione S-transferase isoenzymes in the conjugation of cyclophosphamide metabolites with glutathione.

Dirven, H. A. A. M., van Ommen, B., & van BLADEREN, P. J. (1994) · PubMed · Cited by 163

Cytochrome P450 1B1: a target for inhibition in anticarcinogenesis strategies

Peter Guengerich, F., Chun, Y.-J., Kim, D., Gillam, E. M. J., & Shimada, T. (2003) · Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis · doi:10.1016/s0027-5107(02)00333-0 · Cited by 163

Metabolism of Benzo[a]pyrene to trans-7,8-Dihydroxy-7,8-dihydrobenzo[a]pyrene by Recombinant Human Cytochrome P450 1B1 and Purified Liver Epoxide Hydrolase

Shimada, T., Gillam, E. M. J., Oda, Y., Tsumura, F., Sutter, T. R., Guengerich, F. P., & Inoue, K. (1999) · Chemical Research in Toxicology · doi:10.1021/tx990028s · Cited by 156

Dominant Contribution of P450 3A4 to the Hepatic Carcinogenic Activation of Aflatoxin B1

Kamdem, L. K., Meineke, I., Gödtel‐Armbrust, U., Brockmöller, J., & Wojnowski, L. (2006) · Chemical Research in Toxicology · doi:10.1021/tx050358e · Cited by 153

Metabolic activation of N-hydroxy arylamines and N-hydroxy heterocyclic amines by human sulfotransferase(s).

Chou, H., Np, L., & Kadlubar, F. F. (1995) · PubMed · Cited by 153

Polymorphisms in P450 CYP1B1 affect the conversion of estradiol to the potentially carcinogenic metabolite 4-hydroxyestradiol

Li, D. N., Seidel, A., Pritchard, M. P., Wolf, C. R., & Friedberg, T. (2000) · Pharmacogenetics · doi:10.1097/00008571-200006000-00008 · Cited by 152

The anticancer agent ellipticine on activation by cytochrome P450 forms covalent DNA adducts☆

Stiborová, M., Bieler, C. A., Wießler, M., & Frei, E. (2001) · Biochemical Pharmacology · doi:10.1016/s0006-2952(01)00806-1 · Cited by 150

Structure–function of human 3α-hydroxysteroid dehydrogenases: genes and proteins

Penning, T. M., Jin, Y., Steckelbroeck, S., Rižner, T. L., & Lewis, M. (2004) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2003.11.006 · Cited by 144

Involvement of cytochrome P450, glutathione S-transferase, and epoxide hydrolase in the metabolism of aflatoxin B1 and relevance to risk of human liver cancer.

Guengerich, F. P., Johnson, W. W., Ueng, Y., Yamazaki, H., & Shimada, T. (1996) · Environmental Health Perspectives · doi:10.1289/ehp.96104s3557 · Cited by 142

Expression of Cytochrome-P450-3A5 in Escherichia Coli: Effects of 5′ Modification, Purification, Spectral Characterization, Reconstitution Conditions, and Catalytic Activities

Gillam, E. M. J., Guo, Z., Ueng, Y., Yamazaki, H., Cock, I. E., Reilly, P. E. B., Hooper, W. D., & Guengerich, F. P. (1995) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1995.1177 · Cited by 141

A new selective and potent inhibitor of human cytochrome P450 1B1 and its application to antimutagenesis.

Chun, Y., Kim, S., Kim, D., et al. (2001) · PubMed · Cited by 137

Metabolism of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine by human cytochrome P4501A1, P4501A2 and P4501B1

Crofts, F. (1998) · Carcinogenesis · doi:10.1093/carcin/19.11.1969 · Cited by 137

Efficient activation of aflatoxin B1 by cytochrome P450 2A13, an enzyme predominantly expressed in human respiratory tract

He, X., Tang, L., Wang, S., Cai, Q., Wang, J., & Hong, J. (2005) · International Journal of Cancer · doi:10.1002/ijc.21665 · Cited by 136

Sulfotransferases: genetics and role in toxicology

Glatt, H. R., Engelke, C. E. H., Pabel, U., Teubner, W., Jones, A. L., Coughtrie, M. W. H., Andrae, U., Falany, C. N., & Meinl, W. (2000) · Toxicology Letters · doi:10.1016/s0378-4274(99)00214-3 · Cited by 134

Metabolic activation of the environmental contaminant 3-nitrobenzanthrone by human acetyltransferases and sulfotransferase

Arlt, V. M., Glatt, H., Muckel, E., Pabel, U., Sorg, B. L., Schmeiser, H. H., & Phillips, D. H. (2002) · Carcinogenesis · doi:10.1093/carcin/23.11.1937 · Cited by 133

Metabolic activation of dacarbazine by human cytochromes P450: the role of CYP1A1, CYP1A2, and CYP2E1.

Reid, J. M., Kuffel, M. J., Miller, J. K., Ríos, R., & Ames, M. M. (1999) · PubMed · Cited by 133

Differential metabolism of benzo[a]pyrene and benzo[a]pyrene-7,8-dihydrodiol by human CYP1A1 variants

Schwarz, D. (2001) · Carcinogenesis · doi:10.1093/carcin/22.3.453 · Cited by 132

The Anticancer Drug Ellipticine Forms Covalent DNA Adducts, Mediated by Human Cytochromes P450, through Metabolism to 13-Hydroxyellipticine and EllipticineN2-Oxide

Stiborová, M., Sejbal, J., Bořek-Dohalská, L., Aimová, D., Poljaková, J., Forsterová, K., Rupertová, M., Wiesner, J., Hudeček, J., Wießler, M., et al. (2004) · Cancer Research · doi:10.1158/0008-5472.can-04-2202 · Cited by 132

Effects of human and rat glutathione S-transferases on the covalent DNA binding of the N-acetoxy derivatives of heterocyclic amine carcinogens in vitro: a possible mechanism of organ specificity in their carcinogenesis.

Lin, D., Meyer, D. J., KETTERER, B., Lang, N. P., & Kadlubar, F. F. (1994) · PubMed · Cited by 130

Nature of cytochromes P450 involved in the 2-/4-hydroxylations of estradiol in human liver microsomes

Kerlan, V., Dréano, Y., Bercovici, J. P., Beaune, P. H., Floch, H. H., & Berthou, F. (1992) · Biochemical Pharmacology · doi:10.1016/0006-2952(92)90068-t · Cited by 129

Metabolism of carcinogenic heterocyclic and aromatic amines by recombinant human cytochrome P450 enzymes

Hammons, G. (1997) · Carcinogenesis · doi:10.1093/carcin/18.4.851 · Cited by 126

CYP1B1 determines susceptibility to low doses of 7,12-dimethylbenz[a]anthracene-induced ovarian cancers in mice: correlation of CYP1B1-mediated DNA adducts with carcinogenicity

Buters, J. (2003) · Carcinogenesis · doi:10.1093/carcin/24.2.327 · Cited by 126

Contribution of CYP1A1 and CYP1A2 to the activation of heterocyclic amines in monkeys and human

Edwards, R. J., Murray, B. P., Murray, S., Schulz, T., Neubert, D., Gant, T. W., Thorgeirsson, S. S., Boobis, A. R., & Davies, D. S. (1994) · Carcinogenesis · doi:10.1093/carcin/15.5.829 · Cited by 125

Oxidation of aflatoxins and sterigmatocystin by human liver microsomes: significance of aflatoxin Q1 as a detoxication product of aflatoxin B1

Raney, K. D., Shimada, T., Kim, D., Groopman, J. D., Harris, T. M., & Guengerich, F. P. (1992) · Chemical Research in Toxicology · doi:10.1021/tx00026a009 · Cited by 125

Substrate specificity of human liver cytochrome P-450 debrisoquine 4-hydroxylase probed using immunochemical inhibition and chemical modeling.

Wolff, T., Distlerath, L. M., Worthington, M., Groopman, J. D., Hammons, G., Kadlubar, F. F., Prough, R. A., Martin, M. V., & Guengerich, F. P. (1985) · PubMed · Cited by 124

Glucuronidation of 2-hydroxyamino-1-methyl-6-phenylimidazo[4,5-b]pyridine by human microsomal UDP-glucuronosyltransferases: identification of specific UGT1A family isoforms involved

Nowell, S. A., Massengill, J. S., Williams, S., Radominska-Pandya, A., Tephly, T. R., Cheng, Z., Strassburg, C. P., Tukey, R. H., MacLeod, S. L., Lang, N. P., et al. (1999) · Carcinogenesis · doi:10.1093/carcin/20.6.1107 · Cited by 122

Role of human hepatic cytochrome P450 1A2 and 3A4 in the metabolic activation of estrone

Shou, M. (1997) · Carcinogenesis · doi:10.1093/carcin/18.1.207 · Cited by 121

The Ubiquitous Aldehyde Reductase (AKR1A1) Oxidizes Proximate Carcinogen trans-Dihydrodiols to o-Quinones: Potential Role in Polycyclic Aromatic Hydrocarbon Activation

Palackal, N. T., Burczynski, M. E., Harvey, R. G., & Penning, T. M. (2001) · Biochemistry · doi:10.1021/bi010872t · Cited by 120

Human Enzymes Involved in the Metabolic Activation of Carcinogenic Aristolochic Acids: Evidence for Reductive Activation by Cytochromes P450 1A1 and 1A2

Stiborová, M., Frei, E., Wießler, M., & Schmeiser, H. H. (2001) · Chemical Research in Toxicology · doi:10.1021/tx010059z · Cited by 119

Role of polymorphic human cytochrome P450 enzymes in estrone oxidation

Cribb, A. E., Knight, M. J., Dryer, D., Guernsey, J., Hender, K., Tesch, M., & Saleh, T. M. (2006) · Cancer Epidemiology, Biomarkers & Prevention · doi:10.1158/1055-9965.epi-05-0801 · Cited by 118

Identification of the major human hepatic cytochrome P450 involved in activation and N-dechloroethylation of ifosfamide

Walker, D., Flinois, J.-P., Monkman, S. C., et al. (1994) · Biochemical Pharmacology · doi:10.1016/0006-2952(94)90387-5 · Cited by 118

Tumor-specific expression of the novel cytochrome P450 enzyme, CYP2W1

Karlgren, M., Gomez, A. V., Stark, K., Svärd, J., Rodríguez‐Antona, C., Oliw, E. H., Bernal, M. L., y Cajal, S. R., Johansson, I., & Ingelman‐Sundberg, M. (2006) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2005.12.200 · Cited by 115

Efficient Hypoxic Activation of the Anticancer Agent AQ4N by CYP2S1 and CYP2W1

Nishida, C. R., Lee, M., & de Montellano, P. R. O. (2010) · Molecular Pharmacology · doi:10.1124/mol.110.065045 · Cited by 115

Establishment of the transformants expressing human cytochrome P450 subtypes in HepG2, and their applications on drug metabolism and toxicology

Yoshitomi, S., Ikemoto, K., Takahashi, J., Miki, H., Namba, M., & Asahi, S. (2001) · Toxicology in Vitro · doi:10.1016/s0887-2333(01)00011-x · Cited by 113

The effects of catechol-O-methyltransferase inhibition on estrogen metabolite and oxidative DNA damage levels in estradiol-treated MCF-7 cells.

Lavigne, J. A., Goodman, J. E., Fonong, T., Odwin, S.-A., He, P., Roberts, D. W., & Yager, J. D. (2001) · PubMed · Cited by 113

PURIFICATION AND CHARACTERIZATION OF AKR1B10 FROM HUMAN LIVER: ROLE IN CARBONYL REDUCTION OF XENOBIOTICS

Martin, H.-J., Breyer-Pfaff, U., Wsól, V., Venz, S., Block, S., & Maser, E. (2005) · Drug Metabolism and Disposition · doi:10.1124/dmd.105.007971 · Cited by 112

Metabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in human lung and liver microsomes and cytochromes P-450 expressed in hepatoma cells.

Smith, T. J., Guo, Z., Gonzalez, F. J., Guengerich, F. P., Stoner, G. D., & Yang, C. S. (1992) · PubMed · Cited by 111

Cytochrome P450 2E1 is the primary enzyme responsible for low-dose carbon tetrachloride metabolism in human liver microsomes

Zangar, R. C., Benson, J. M., Burnett, V. L., et al. (2000) · Chemico-Biological Interactions · doi:10.1016/s0009-2797(00)00149-6 · Cited by 111

Update Information on Drug Metabolism Systems— 2009, Part II. Summary of Information on the Effects of Diseases and Environmental Factors on Human Cytochrome P450 (CYP) Enzymes and Transporters

Rendic, S. P., & Guengerich, F. P. (2010) · Current Drug Metabolism · doi:10.2174/138920010791110917 · Cited by 111

CYP2E1 – Biochemical and Toxicological Aspects and Role in Alcohol-Induced Liver Injury

Cederbaum, A. I. (2008) · Springer eBooks · doi:10.1007/978-0-387-77300-1_6 · Cited by 110

SHORT COMMUNICATION: Human glutathione S-transferase T1–1 enhances mutagenicity of 1, 2-dibromoethane, dibromomethane and 1,2,3,4-diepoxybutane in Salmonella typhimurium

Thier, R., Pemble, S. E., Kramer, H., Taylor, J. B., Guengerich, F. P., & KETTERER, B. (1996) · Carcinogenesis · doi:10.1093/carcin/17.1.163 · Cited by 110

Glutathione Conjugation of Bay- and Fjord-Region Diol Epoxides of Polycyclic Aromatic Hydrocarbons by Glutathione Transferases M1-1 and P1-1

Sundberg, K., Widersten, M., Seidel, A., Mannervik, B., & Jernström, B. (1997) · Chemical Research in Toxicology · doi:10.1021/tx970099w · Cited by 109

Reverse geometrical selectivity in glucuronidation and sulfation of cis- and trans-4-hydroxytamoxifens by human liver UDP-glucuronosyltransferases and sulfotransferases

Nishiyama, T., Ogura, K., Nakano, H., Ohnuma, T., Kaku, T., Hiratsuka, A., Muro, K., & Watabe, T. (2002) · Biochemical Pharmacology · doi:10.1016/s0006-2952(02)00994-2 · Cited by 109

Herbal bioactivation, molecular targets and the toxicity relevance

Chen, X., Serag-Bolos, E. S., Sneed, K., & Zhou, S. (2011) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2011.03.016 · Cited by 109

Role of human aldo–keto-reductase AKR1B10 in the protection against toxic aldehydes

Martin, H.-J., & Maser, E. (2008) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2008.10.021 · Cited by 109

METABOLISM OF NICOTINE AND COTININE BY HUMAN CYTOCHROME P450 2A13

Bao, Z., He, X., Ding, X., Prabhu, S., & Hong, J. (2004) · Drug Metabolism and Disposition · doi:10.1124/dmd.104.002105 · Cited by 109

Characterization of cytochrome P-450 2B6 in human liver microsomes.

Mimura, M., Baba, T., Yamazaki, H., Ohmori, S., Inui, Y., Gonzalez, F. J., Guengerich, F. P., & Shimada, T. (1993) · Drug Metabolism and Disposition · doi:10.1016/s0090-9556(25)08198-x · Cited by 109

Expression of Modified Human Cytochrome P450 1A1 in Escherichia coli: Effects of 5′ Substitution, Stabilization, Purification, Spectral Characterization, and Catalytic Properties

Guo, Z., Gillam, E. M. J., Ohmori, S., Tukey, R. H., & Guengerich, F. P. (1994) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1994.1330 · Cited by 106

Identification and Tissue Distribution of the Novel Human Cytochrome P450 2S1 (CYP2S1)

Rylander‐Rudqvist, T., Neve, E. P. A., Ingelman‐Sundberg, M., & Oscarson, M. (2001) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2001.4390 · Cited by 106

Meta-analysis of studies of the CYP2D6 polymorphism in relation to lung cancer and Parkinson??s disease

Rostami‐Hodjegan, A., Lennard, M. S., Woods, H. F., & Tucker, G. T. (1998) · Pharmacogenetics · doi:10.1097/00008571-199806000-00005 · Cited by 104

Metabolic activation of N -alkylnitrosamines in genetically engineered Salmonella typhimurium expressing CYP2E1 or CYP2A6 together with human NADPH-cytochrome P450 reductase

Kushida, H., Fujita, K., Suzuki, A., Yamada, M., Endo, T., Nohmi, T., & Kamataki, T. (2000) · Carcinogenesis · doi:10.1093/carcin/21.6.1227 · Cited by 103

Orphans in the Human Cytochrome P450 Superfamily: Approaches to Discovering Functions and Relevance in Pharmacology

Guengerich, F. P., & Cheng, Q. (2011) · Pharmacological Reviews · doi:10.1124/pr.110.003525 · Cited by 103

Evidence for cytochrome P450 2A6 and 3A4 as major catalysts for N'- nitrosonornicotine alpha-hydroxylation by human liver microsomes

Patten, C. (1997) · Carcinogenesis · doi:10.1093/carcin/18.8.1623 · Cited by 102

Salmonella typhimurium strains expressing human arylamine N-acetyltransferases: metabolism and mutagenic activation of aromatic amines.

Grant, D., Josephy, P. D., Lord, H. L., & Morrison, L. D. (1992) · PubMed · Cited by 101

Contribution of human hepatic cytochrome P450 isoforms to regioselective hydroxylation of steroid hormones

Niwa, T., Yabusaki, Y., Honma, K., MATSUO, N., 龍田, 佳., Ishibashi, F., & KATAGIRI, M. (1998) · Xenobiotica · doi:10.1080/004982598239290 · Cited by 101

Human aldo–keto reductases 1B1 and 1B10: A comparative study on their enzyme activity toward electrophilic carbonyl compounds

Shen, Y., Zhong, L., Johnson, S. R., & Cao, D. (2011) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2011.02.004 · Cited by 101

Novel extrahepatic cytochrome P450s

Karlgren, M., MIURA, S., & Ingelman‐Sundberg, M. (2005) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2004.12.022 · Cited by 101

Selection and Characterization of Human Cytochrome P450 1A2 Mutants with Altered Catalytic Properties

Parikh, A., Josephy, P. D., & Guengerich, F. P. (1999) · Biochemistry · doi:10.1021/bi990142+ · Cited by 99

Recombinant Enzymes Overexpressed in Bacteria Show Broad Catalytic Specificity of Human Cytochrome P450 2W1 and Limited Activity of Human Cytochrome P450 2S1

Wu, Z., Sohl, C. D., Shimada, T., & Guengerich, F. P. (2006) · Molecular Pharmacology · doi:10.1124/mol.106.023648 · Cited by 99

Human hepatic and renal microsomes, cytochromes P450 1A1/2, NADPH:Cytochrome P450 reductase and prostaglandin H synthase mediate the formation of aristolochic acid‐DNA adducts found in patients with urothelial cancer

Stiborová, M., Frei, E., Hodek, P., Wießler, M., & Schmeiser, H. H. (2004) · International Journal of Cancer · doi:10.1002/ijc.20564 · Cited by 97

Characterization of benzo(a)pyrene-trans-7,8-dihydrodiol glucuronidation by human tissue microsomes and overexpressed UDP-glucuronosyltransferase enzymes.

Fang, J., Beland, F. A., Doerge, D. R., Wiener, D. A., Guillemette, C., Marques, M. M., & Lazarus, P. J. (2002) · PubMed · Cited by 96

Roles of human liver cytochrome P4502C and 3A enzymes in the 3-hydroxylation of benzo(a)pyrene.

Yun, C., Shimada, T., & Guengerich, F. P. (1992) · PubMed · Cited by 95

Characterization of the NADPH-Dependent Metabolism of 17β-Estradiol to Multiple Metabolites by Human Liver Microsomes and Selectively Expressed Human Cytochrome P450 3A4 and 3A5

Lee, A. J., Kosh, J. W., Conney, A. H., & Zhu, B. T. (2001) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)29399-x · Cited by 95

IMPORTANCE OF UDP-GLUCURONOSYLTRANSFERASE 1A10 (UGT1A10) IN THE DETOXIFICATION OF POLYCYCLIC AROMATIC HYDROCARBONS: DECREASED GLUCURONIDATIVE ACTIVITY OF THE UGT1A10139LYS ISOFORM

Dellinger, R. W., Fang, J., Chen, G., Weinberg, R., & Lazarus, P. J. (2006) · Drug Metabolism and Disposition · doi:10.1124/dmd.105.009100 · Cited by 94

Benzene metabolism by human liver microsomes in relation to cytochrome P450 2E1 activity

Seaton, M. J., Schlosser, P. M., Bond, J. A., & Medinsky, M. A. (1994) · Carcinogenesis · doi:10.1093/carcin/15.9.1799 · Cited by 93

The UDP-Glucuronosyltransferase 2B17 Gene Deletion Polymorphism: Sex-Specific Association with Urinary 4-(Methylnitrosamino)-1-(3-Pyridyl)-1-Butanol Glucuronidation Phenotype and Risk for Lung Cancer

Gallagher, C. J., Muscat, J. E., Hicks, A. N., Zheng, Y., Dyer, A.-M., Chase, G. A., Richie, J. P., & Lazarus, P. J. (2007) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-06-0823 · Cited by 92

Characterization of the NADPH-dependent metabolism of 17beta-estradiol to multiple metabolites by human liver microsomes and selectively expressed human cytochrome P450 3A4 and 3A5.

Lee, A. J., Kosh, J. W., Conney, A. H., & Zhu, B. T. (2001) · PubMed · Cited by 92

Recombinant Human Cytochrome P450 1B1 Expression inEscherichia coli

Shimada, T., Wunsch, R. M., Hanna, I. H., Sutter, T. R., Guengerich, F. P., & Gillam, E. M. J. (1998) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1998.0808 · Cited by 91

Association of CYP1A1 Polymorphisms with Differential Metabolic Activation of 17β-Estradiol and Estrone

Kisselev, P., Schunck, W., Roots, I., & Schwarz, D. (2005) · Cancer Research · doi:10.1158/0008-5472.can-04-3543 · Cited by 91

Activation of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in human lung microsomes by cytochromes P450, lipoxygenase, and hydroperoxides.

Smith, T. J., Stoner, G. D., & Yang, C. (1995) · PubMed · Cited by 89

Metabolism of 2-Amino-3,8-dimethylimidazo[4,5-f]- quinoxaline in Human Hepatocytes: 2-Amino-3-methylimidazo[4,5-f]quinoxaline-8-carboxylic Acid Is a Major Detoxication Pathway Catalyzed by Cytochrome P450 1A2

Langouët, S., Welti, D. H., Kerriguy, N., Fay, L. B., Tuong, H. B., Markovic, J., Guengerich, F. P., Guillouzo, A., & Turesky, R. J. (2001) · Chemical Research in Toxicology · doi:10.1021/tx000176e · Cited by 89

Ellipticine cytotoxicity to cancer cell lines - a comparative study

Stiborová, M., Poljaková, J., Martínková, E., Bořek-Dohalská, L., Eckschlager, T., Kizek, R., & Frei, E. (2011) · Interdisciplinary Toxicology · doi:10.2478/v10102-011-0017-7 · Cited by 89

Characterization of tamoxifen and 4-hydroxytamoxifen glucuronidation by human UGT1A4 variants

Sun, D., Chen, G., Dellinger, R. W., Duncan, K., Fang, J., & Lazarus, P. J. (2006) · Breast Cancer Research · doi:10.1186/bcr1539 · Cited by 89

Correlation between UDP-Glucuronosyltransferase Genotypes and 4-(Methylnitrosamino)-1-(3-Pyridyl)-1-Butanone Glucuronidation Phenotype in Human Liver Microsomes

Wiener, D. A., Fang, J., Dossett, N., & Lazarus, P. J. (2004) · Cancer Research · doi:10.1158/0008-5472.can-03-3219 · Cited by 89

Role of CYP2B6 and CYP3A4 in the In Vitro N-Dechloroethylation of (R)- and (S)-Ifosfamide in Human Liver Microsomes

Granvil, C. P., Madan, A., Sharkawi, M., et al. (1999) · Drug Metabolism and Disposition · doi:10.1016/s0090-9556(24)15217-8 · Cited by 89

Predicting the mutagenicity of tobacco‐related N‐nitrosamines in humans using 11 strains of Salmonella typhimurium YG7108, each coexpressing a form of human cytochrome P450 along with NADPH–cytochrome P450 reductase

Fujita, K., & Kamataki, T. (2001) · Environmental and Molecular Mutagenesis · doi:10.1002/em.10036 · Cited by 88

Differential protection against benzo[a]pyrene-7,8-dihydrodiol-9,10-epoxide-induced DNA damage in HepG2 cells stably transfected with allelic variants of pi class human glutathione S-transferase.

Hu, X., Herzog, C., Zimniak, P., & Singh, S. V. (1999) · PubMed · Cited by 87

CARCINOGENESIS: Glutathione S-transferase A1–1-catalysed conjugation of bay and fjord region diol epoxides of polycyclic aromatic hydrocarbons with glutathione

Jernström, B., Funk, M., Frank, H., Mannervik, B., & Seidel, A. (1996) · Carcinogenesis · doi:10.1093/carcin/17.7.1491 · Cited by 86

Human sulphotransferases are involved in the activation of aristolochic acids and are expressed in renal target tissue

Meinl, W., Pabel, U., Osterloh‐Quiroz, M., Hengstler, J. G., & Glatt, H. R. (2005) · International Journal of Cancer · doi:10.1002/ijc.21480 · Cited by 85

Human enzymes involved in the metabolic activation of the environmental contaminant 3-nitrobenzanthrone: evidence for reductive activation by human NADPH:cytochrome p450 reductase.

Arlt, V. M., Stiborová, M., Hewer, A. J., Schmeiser, H. H., & Phillips, D. H. (2003) · PubMed · Cited by 84

Kinetic Analysis of the Activation of 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone by Heterologously Expressed Human P450 Enzymes and the Effect of P450- Specific Chemical Inhibitors on This Activation in Human Liver Microsomes

Patten, C., Smith, T. J., Murphy, S. E., Wang, M.-H., Lee, J. M., Tynes, R. E., Koch, P., & Yang, C. S. (1996) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1996.0373 · Cited by 84

Oxidation of PAH trans-Dihydrodiols by Human Aldo-Keto Reductase AKR1B10

Quinn, A. M., Harvey, R. G., & Penning, T. M. (2008) · Chemical Research in Toxicology · doi:10.1021/tx8002005 · Cited by 83

Genetic Polymorphisms of the Human CYP2A13 Gene: Identification of Single-Nucleotide Polymorphisms and Functional Characterization of an Arg257Cys Variant

Zhang, X., Su, T., Zhang, Q.-Y., Gu, J., Caggana, M., Li, H., & Ding, X. (2002) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.302.2.416 · Cited by 83

GLUTATHIONE TRAPPING TO MEASURE MICROSOMAL OXIDATION OF FURAN TO CIS-2-BUTENE-1,4-DIAL

Peterson, L. A., Cummings, M. E., Vu, C. C., et al. (2005) · Drug Metabolism and Disposition · doi:10.1124/dmd.105.004432 · Cited by 82

Sulfotransferase-mediated activation of mutagens studied using heterologous expression systems

Glatt, H. R., Bartsch, I., Christoph, S., Coughtrie, M. W. H., Falany, C. N., Hagen, M., Landsiedel, R., Pabel, U., Phillips, D. H., Seidel, A., et al. (1998) · Chemico-Biological Interactions · doi:10.1016/s0009-2797(97)00133-6 · Cited by 82

In vivoRole of CytochromeP450 2E1 and Glutathione-S-Transferase Activity for Acrylamide Toxicokinetics in Humans

Doroshyenko, O., Fuhr, U., Kunz, D., Frank, D., Kinzig, M., Jetter, A., Reith, Y., Lazar, A., Taubert, D., Kirchheiner, J., et al. (2009) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-08-0832 · Cited by 80

Sulfation of alpha-hydroxytamoxifen catalyzed by human hydroxysteroid sulfotransferase results in tamoxifen-DNA adducts

Shibutani, S. (1998) · Carcinogenesis · doi:10.1093/carcin/19.11.2007 · Cited by 80

NADPH-dependent metabolism of 17β-estradiol and estrone to polar and nonpolar metabolites by human tissues and cytochrome P450 isoforms

Zhu, B. T., & Lee, A. J. (2005) · Steroids · doi:10.1016/j.steroids.2005.01.002 · Cited by 79

Bioactivation of aflatoxin B1 by human liver microsomes: Role of cytochrome P450 IIIA enzymes

Ramsdell, H. S., Parkinson, A., Eddy, A. C., & Eaton, D. L. (1991) · Toxicology and Applied Pharmacology · doi:10.1016/0041-008x(91)90090-2 · Cited by 78

Light pollution, reproductive function and cancer risk.

Stiborová, M., Martínek, V., Schmeiser, H. H., & Frei, E. (2006) · PubMed · Cited by 77

Human Cytochrome P450 Enzyme Specificity for Bioactivation of Safrole to the Proximate Carcinogen 1‘-Hydroxysafrole

Jeurissen, S. M. F., Bogaards, J. J. P., Awad, H. M., et al. (2004) · Chemical Research in Toxicology · doi:10.1021/tx040001v · Cited by 77

N-Glucuronidation of 2-amino-1-methyl-6-phenylimidazo [4,5-b]pyridine (PhIP) and N-hydroxy-PhIP by specific human UDP-glucuronosyltransferases

Malfatti, M. A., & Felton, J. S. (2001) · Carcinogenesis · doi:10.1093/carcin/22.7.1087 · Cited by 76

Cytochrome P450-Dependent Metabolism of Trichloroethylene: Interindividual Differences in Humans

Lipscomb, J. C., Garrett, C. M., & SNAWDER, J. E. (1997) · Toxicology and Applied Pharmacology · doi:10.1006/taap.1996.8040 · Cited by 76

Catalytic efficiencies of allelic variants of human glutathione S-transferase P1-1 toward carcinogenic anti-diol epoxides of benzo[c]phenanthrene and benzo[g]chrysene.

Hu, X., Xia, H., Srivastava, S., Pal, A., Awasthi, S., Zimniak, P., & Singh, S. V. (1998) · PubMed · Cited by 76

Purification and characterization of oxidoreductases-catalyzing carbonyl reduction of the tobacco-specific nitrosamine 4-methylnitrosamino-1-(3-pyridyl)-1-butanone (NNK) in human liver cytosol

Atalla, A., Breyer-Pfaff, U., & Maser, E. (2000) · Xenobiotica · doi:10.1080/00498250050119826 · Cited by 75

Activation of 3‐nitrobenzanthrone and its metabolites by human acetyltransferases, sulfotransferases and cytochrome P450 expressed in Chinese hamster V79 cells

Arlt, V. M., Glatt, H. R., Muckel, E., Pabel, U., Sorg, B. L., Seidel, A., Frank, H., Schmeiser, H. H., & Phillips, D. H. (2003) · International Journal of Cancer · doi:10.1002/ijc.11143 · Cited by 75

Specificity of 17β-oestradiol and benzo[α]pyrene oxidation by polymorphic human cytochrome P4501B1 variants substituted at residues 48, 119 and 432

Shimada, T., Watanabe, J. A., Inoue, K., et al. (2001) · Xenobiotica · doi:10.1080/00498250110043490 · Cited by 74

Functional characterization of four allelic variants of human cytochrome P450 1A2

Zhou, H., Josephy, P. D., Kim, D., & Guengerich, F. P. (2003) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2003.11.019 · Cited by 73

Human cDNA‐Expressed Cytochrome P450 IA2: Mutagen Activation and Substrate Specificity

Aoyama, T., Gonzalez, F. J., & Gelboin, H. V. (1989) · Molecular Carcinogenesis · doi:10.1002/mc.2940020405 · Cited by 73

Bioactivation of 4-Ipomeanol by CYP4B1: Adduct Characterization and Evidence for an Enedial Intermediate

Baer, B. R., Rettie, A. E., & Henne, K. R. (2005) · Chemical Research in Toxicology · doi:10.1021/tx0496993 · Cited by 71

Quaternary ammonium-linked glucuronidation of tamoxifen by human liver microsomes and UDP-glucuronosyltransferase 1A4

Kaku, T., Ogura, K., Nishiyama, T., Ohnuma, T., Muro, K., & Hiratsuka, A. (2004) · Biochemical Pharmacology · doi:10.1016/j.bcp.2004.02.014 · Cited by 71

Cytochrome P-450 3A and 2D6 Catalyze Ortho Hydroxylation of 4-Hydroxytamoxifen and 3-Hydroxytamoxifen (Droloxifene) Yielding Tamoxifen Catechol: Involvement of Catechols in Covalent Binding to Hepatic Proteins

Dehal, S. S., & Kupfer, D. (1999) · Drug Metabolism and Disposition · doi:10.1016/s0090-9556(24)15305-6 · Cited by 71

Stereoselective Metabolism of Ifosfamide by Human P-450s 3A4 and 2B6. Favorable Metabolic Properties of R-Enantiomer

Roy, P., Tretyakov, O., Wright, J., et al. (1999) · Drug Metabolism and Disposition · doi:10.1016/s0090-9556(24)14934-3 · Cited by 71

Cytochrome P450 metabolic dealkylation of nine N-nitrosodialkylamines by human liver microsomes

Bellec, G., Dréano, Y., Lozach, P., Menez, J. F., & Berthou, F. (1996) · Carcinogenesis · doi:10.1093/carcin/17.9.2029 · Cited by 71

16Alpha-hydroxylation of estrone by human cytochrome P4503A4/5

Huang, Z. (1998) · Carcinogenesis · doi:10.1093/carcin/19.5.867 · Cited by 70

Role of human cytochrome P450 (CYP) in the metabolic activation of N-alkylnitrosamines: application of genetically engineered Salmonella typhimurium YG7108 expressing each form of CYP together with human NADPH-cytochrome P450 reductase

Fujita, K., & Kamataki, T. (2001) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/s0027-5107(01)00223-8 · Cited by 70

Benzene metabolism in human lung cell lines BEAS‐2B and A549 and cells overexpressing CYP2F1

Sheets, P. L., Yost, G. S., & Carlson, G. P. (2004) · Journal of Biochemical and Molecular Toxicology · doi:10.1002/jbt.20010 · Cited by 70

MOLECULAR MECHANISMS OF ANTINEOPLASTIC ACTION OF AN ANTICANCER DRUG ELLIPTICINE

Stiborová, M., Rupertová, M., Schmeiser, H. H., & Frei, E. (2006) · Biomedical Papers · doi:10.5507/bp.2006.002 · Cited by 68

CYP4B1 Is a Possible Risk Factor for Bladder Cancer in Humans

Imaoka, S., Yoneda, Y., Sugimoto, T., Hiroi, T., Yamamoto, K., Nakatani, T., & Funae, Y. (2000) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2000.3740 · Cited by 68

Bioactivation versus Detoxication of the Urothelial Carcinogen Aristolochic Acid I by Human Cytochrome P450 1A1 and 1A2

Stiborová, M., Levová, K., Bárta, F., Shi, Z., Frei, E., Schmeiser, H. H., Nebert, D. W., Phillips, D. H., & Arlt, V. M. (2011) · Toxicological Sciences · doi:10.1093/toxsci/kfr306 · Cited by 68

Glucuronidation of Tobacco-Specific Nitrosamines by UGT2B10

Chen, G., Dellinger, R. W., Sun, D., Spratt, T. E., & Lazarus, P. J. (2008) · Drug Metabolism and Disposition · doi:10.1124/dmd.107.019406 · Cited by 68

Formation and Biological Targets of Quinones: Cytotoxic versus Cytoprotective Effects

Bolton, J. L., & Dunlap, T. (2017) · Chemical Research in Toxicology · doi:10.1021/acs.chemrestox.6b00256 · Cited by 522

Survey of Human Oxidoreductases and Cytochrome P450 Enzymes Involved in the Metabolism of Xenobiotic and Natural Chemicals

Rendic, S., & Guengerich, F. P. (2015) · Chemical Research in Toxicology · doi:10.1021/tx500444e · Cited by 477

Characterization of cytochrome P450s (CYP)-overexpressing HepG2 cells for assessing drug and chemical-induced liver toxicity

Chen, S., Wu, Q., Li, X., Li, D., Mei, N., Ning, B., Puig, M., Ren, Z., Tolleson, W. H., & Guo, L. (2021) · Journal of Environmental Science and Health, Part C · doi:10.1080/26896583.2021.1880242 · Cited by 44