The DOI matches its Crossref record; 47 of the 47 references it cites were found in a registry or an index.
Marine pharmacology
Abstract
Marine organisms have provided a large proportion of the bioactive natural products reported over the last 20 years, but none of these compounds have reached the pharmaceutical marketplace. This review describes current progress in the development of a selection of new antiinflammatory and anticancer agents, discusses some difficulties encountered during the development process and suggests how these difficulties may be overcome in the near future through applications of recent advances in biotechnology.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Furthermore, some marine organisms, such as microflora (bacteria, actinobacteria, cyanobacteria and fungi), microalgae, macroalgae (seaweeds) [31], invertebrate animals [37,38] sponges, soft corals, sea fans, sea hares, nudibranchs, bryozoans, tunicates, etc. [2], have been investigated for cancer control [39,40].”
From Marine Natural Products: A Source of Novel Anticancer Drugs (2019) · cites this paper as [40]
Citations
Cites
Isolation and structure of bryostatin 1
Pettit, G. R., Herald, C. L., Doubek, D. L., Herald, D. L., Arnold, E., & Clardy, J. (1982) · Journal of the American Chemical Society · doi:10.1021/ja00388a092 · Cited by 653
The isolation and structure of a remarkable marine animal antineoplastic constituent: dolastatin 10
Pettit, G. R., Kamano, Y., Herald, C. L., Tuinman, A. A., Boettner, F. E., Kizu, H., Schmidt, J. M., Baczynskyj, L., Tomer, K. B., & Bontems, R. J. (1987) · Journal of the American Chemical Society · doi:10.1021/ja00256a070 · Cited by 583
Halichondrins-antitumor polyether macrolides from a marine sponge
Hirata, Y., & Uemura, D. (1986) · Pure and Applied Chemistry · doi:10.1351/pac198658050701 · Cited by 519
RINEHART, K. L. J., Holt, T. G., Fregeau, N. L., Stroh, J. G., Keifer, P. A., Sun, F.-R., Li, L. H., & Martin, D. G. (1990) · The Journal of Organic Chemistry · doi:10.1021/jo00302a007 · Cited by 493
The structure of scytonemin, an ultraviolet sunscreen pigment from the sheaths of cyanobacteria
Proteau, P. J., Gerwick, W. H., Garcia-Pichel, F., & Castenholz, R. (1993) · Experientia · doi:10.1007/bf01923559 · Cited by 392
Discodermolide, A Cytotoxic Marine Agent That Stabilizes Microtubules More Potently Than Taxol,
ter Haar, E., Kowalski, R. J., Hamel, E., Lin, C. M., Longley, R. E., Gunasekera, S. P., Rosenkranz, H. S., & Day, B. W. (1996) · Biochemistry · doi:10.1021/bi9515127 · Cited by 382
Gunasekera, S. P., Gunasekera, M., Longley, R. E., & Schulte, G. K. (1990) · The Journal of Organic Chemistry · doi:10.1021/jo00303a029 · Cited by 377
Gerwick, W. H., Proteau, P. J., Nagle, D. G., Hamel, E., Blokhin, A., & Slate, D. L. (1994) · The Journal of Organic Chemistry · doi:10.1021/jo00085a006 · Cited by 365
Jasplakinolide, a cyclodepsipeptide from the marine sponge, SP.
Crews, P., Manes, L. V., & Boehler, M. A. (1986) · Tetrahedron Letters · doi:10.1016/s0040-4039(00)84645-6 · Cited by 319
Didemnins: Antiviral and Antitumor Depsipeptides from a Caribbean Tunicate
Rinehart, K. L., Gloer, J. B., Hughes, R. G., Renis, H. E., McGovren, J. P., Swynenberg, E. B., Stringfellow, D. A., Kuentzel, S. L., & Li, L. H. (1981) · Science · doi:10.1126/science.7233187 · Cited by 314
Flagged first, then by citations
Research works printed but not linked: 5
- Ahond A, Bedoya Zurita M, Colin M, Fizames C, Laboute P, Lavelle F, Laurent D, Poupat C, Pusset J, Pusset M, Thoison O & Potier P (1988) La girolline, nouvelle substance antitumorale extraite de l'éponge, Pseudaxinyssa cantharella n. sp. (Axinellidae). CR Acad. Sci. Paris, Série II 307: 145–148.
- Battershill CN, Page MJ, Duckworth AR, Miller KA, Bergquist PR, Blunt JW, Munro MHG, Northcote PT, Newman DJ & Pomponi SA (1998) Discovery and sustainable supply of marine natural products as drugs, industrial compounds and agrochemicals: chemical ecology, genetics, aquaculture and cell culture. Abstracts, 5th International Sponge Symposium, Brisbane, p. 16.
- Faulkner DJ (1993) Academic chemistry and the discovery of bioactive marine natural products. In: Attaway DH & Zaborsky OR (Eds.). Marine Biotechnology, Vol. 1 Pharmaceutical and Bioactive Natural Products, Plenum Press, New York. pp 459–474.
- Glaser KB, de Carvalho MS, Jacobs RS, Kernan MR & Faulkner DJ (1989) Manoalide: structure-activity studies and definition of the pharmacophore for phospholipase A2 inactivation. Mol. Phys. 36: 782–788.
- Sigel MM, Wellham LL, Lichter W, Dudeck LE, Gargus J & Lucas AH (1969) Anticellular and antitumor activity of extracts from tropical marine invertebrates. In: Younghen HW Jr (Ed), Food-Drugs from the Sea Proceedings, pp 281–294. Marine Technology Society, Washington DC.
Cited by
Sorted by citations
Marine Natural Products: A Source of Novel Anticancer Drugs
Khalifa, S. A. M., Elias, N., Farag, M. A., Chen, L., Saeed, A., Hegazy, M.-E. F., Moustafa, M. S., Abd El-Wahed, A., Al-Mousawi, S. M., Musharraf, S. G., et al. (2019) · Marine Drugs · doi:10.3390/md17090491 · Cited by 555
“[2], have been investigated for cancer control [39,40].”
BackgroundSearch and Discovery Strategies for Biotechnology: the Paradigm Shift
Bull, A. T., Ward, A. C., & Goodfellow, M. (2000) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.64.3.573-606.2000 · Cited by 480
Leal, M. C., Puga, J., Serôdio, J., Gomes, N. C. M., & Calado, R. (2012) · PLoS ONE · doi:10.1371/journal.pone.0030580 · Cited by 315
Natural products as targeted modulators of the nuclear factor-κB pathway
Bremner, P., & Heinrich, M. (2002) · Journal of Pharmacy and Pharmacology · doi:10.1211/0022357021778637 · Cited by 312
Rocha, J., Peixe, L. M. S. V., Gomes, N. C. M., & Calado, R. (2011) · Marine Drugs · doi:10.3390/md9101860 · Cited by 284
Metadata
- Authors
- Faulkner, D. J.
- Affiliations
- Scripps Institution of Oceanography (US)
- Corresponding author
- Faulkner, D. John
- Venue
- Antonie van Leeuwenhoek
- Published
- 2000-02
- Volume
- 77
- Issue
- 2
- Pages
- 135-145
- ISSN
- 0003-6072 (ISSN-L)
- 1572-9699
- OpenAlex
- W4242920043
- Cited by
- 168
- References
- 47
- Citations by year
- 2025: 2 · 2024: 1 · 2023: 2 · 2022: 8 · 2021: 3 · 2020: 7 · 2019: 8 · 2018: 2 · 2017: 4 · 2016: 2 · 2015: 7 · 2014: 14 · 2013: 7 · 2012: 14
- FWCI
- 0.76
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Antonie van Leeuwenhoek (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biotechnology › Marine Sponges and Natural Products
- Life Sciences › Immunology and Microbiology › Applied Microbiology and Biotechnology › Microbial Natural Products and Biosynthesis
- Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
- Keywords
- marine natural products, bioactive compounds, anti-inflammatory agents, anticancer agents, drug development, marine organisms, biotechnology applications
- MeSH terms
- Biological Factors, Seawater
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
