Cited by 50Microbial Natural Products and BiosynthesisMicrobial Metabolic Engineering and BioproductionBacterial Genetics and Biotechnology
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Growth limiting substrate affects antibiotic production and associated metabolic fluxes in Streptomyces clavuligerus
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Production of clavulanic acid could be improved by refining the composition of the fermentation media.
“Given that both arginine and glyceraldehyde-3-phosphate play an important role in primary metabolism, the production of clavulanic acid could be improved by refining the composition of the fermentation media (Kirk et al., 2000).”
From Fermentation Conditions that Affect Clavulanic Acid Production in Streptomyces clavuligerus: A Systematic Review (2016) · cites this paper as Kirk et al., 2000
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Research works printed but not linked: 29
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Ser, H.-L., Law, J. W.-F., Chaiyakunapruk, N., Jacob, S. A., Palanisamy, U. D., Chan, K.-G., Goh, B.-H., & Lee, L.-H. (2016) · Frontiers in Microbiology · doi:10.3389/fmicb.2016.00522 · Cited by 90
“Given that both arginine and glyceraldehyde-3-phosphate play an important role in primary metabolism, the production of clavulanic acid could be improved by refining the composition of the fermentation media (Kirk et al., 2000).”
BackgroundChen, K.-C., Lin, Y.-H., Tsai, C.-M., Hsieh, C.-H., & Houng, J.-Y. (2002) · Biotechnology Letters · doi:10.1023/a:1014553109425 · Cited by 38
Metadata
- Authors
- Kirk, S., Avignone-Rossa, C. A., & Bushell, M. E.
- Affiliations
- University of Surrey (GB)
- Venue
- Biotechnology Letters
- Published
- 2000-11
- Volume
- 22
- Issue
- 22
- Pages
- 1803-1809
- ISSN
- 0141-5492 (ISSN-L)
- 1573-6776
- OpenAlex
- W265480990
- Cited by
- 50
- References
- 0
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 1 · 2023: 1 · 2022: 1 · 2021: 3 · 2020: 2 · 2019: 1 · 2018: 2 · 2017: 1 · 2016: 2 · 2015: 2 · 2014: 1 · 2013: 5 · 2012: 1
- FWCI
- 0.66
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Biotechnology Letters (publishedVersion)
- Open Research (University of Surrey) (submittedVersion)
- Surrey Research Insight Open Access (The University of Surrey) (submittedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Applied Microbiology and Biotechnology › Microbial Natural Products and Biosynthesis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Microbial Metabolic Engineering and Bioproduction
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
- Keywords
- clavulanic acid biosynthesis, Streptomyces clavuligerus, nutrient limitation, carbon limitation, nitrogen limitation, phosphate limitation, metabolic flux analysis, anaplerotic metabolism, alpha-ketoglutarate, TCA cycle, antibiotic production, chemostat culture
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