Optimization of glycerol feeding for clavulanic acid production by Streptomyces clavuligerus with glycerol feeding
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Comparing batch and fed-batch fermentation, fed-batch fermentation systems seemed to generate a higher yield of clavulanic acid.
“Comparing batch and fed-batch fermentation, fed-batch fermentation systems seemed to generate a higher yield of clavulanic acid (Chen et al., 2002; Neto et al., 2005; Bellão et al., 2013).”
From Fermentation Conditions that Affect Clavulanic Acid Production in Streptomyces clavuligerus: A Systematic Review (2016) · cites this paper as Chen et al., 2002
Glycerol shows a biphasic dose response, with clavulanic acid production inhibited at concentrations that are either too high or too low.
“Additionally, two other studies by Chen et al. (2002) and Saudagar and Singhal (2007a) revealed a biphasic dose response of glycerol; whereby clavulanic acid production was inhibited at concentrations which were either too high or too low.”
From Fermentation Conditions that Affect Clavulanic Acid Production in Streptomyces clavuligerus: A Systematic Review (2016) · cites this paper as Chen et al. (2002)
Cites
Naturally-occurring beta-lactamase inhibitors with antibacterial activity
BROWN, A. G., BUTTERWORTH, D., COLE, M., HANSCOMB, G., HOOD, J. D., READING, C., & ROLINSON, G. N. (1976) · The Journal of Antibiotics · doi:10.7164/antibiotics.29.668 · Cited by 399 · see citing works
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Ser, H.-L., Law, J. W.-F., Chaiyakunapruk, N., Jacob, S. A., Palanisamy, U. D., Chan, K.-G., Goh, B.-H., & Lee, L.-H. (2016) · Frontiers in Microbiology · doi:10.3389/fmicb.2016.00522 · Cited by 90 · see citing works
“Additionally, two other studies by Chen et al. (2002) and Saudagar and Singhal (2007a) revealed a biphasic dose response of glycerol; whereby clavulanic acid production was inhibited at concentrations which were either too high or too low.”
BackgroundFeng, T., Zhao, J., Bai, Y.-F., Chu, J., Wang, Y.-H., & Zhuang, Y.-P. (2022) · Preparative Biochemistry & Biotechnology · doi:10.1080/10826068.2021.2009860 · Cited by 3 · see citing works
- Authors
- Chen, K.-C., Lin, Y.-H., Tsai, C.-M., Hsieh, C.-H., & Houng, J.-Y.
- Affiliations
- National Tsing Hua University (TW)
- I-Shou University (TW)
- Corresponding author
- Chen, Kuo-Cheng
- ORCID
- Houng, Jer-Yiing
- Venue
- Biotechnology Letters
- Published
- 2002-03
- Volume
- 24
- Issue
- 6
- Pages
- 455-458
- ISSN
- 0141-5492 (ISSN-L)
- 1573-6776
- OpenAlex
- W2253845724
- Cited by
- 38
- References
- 1
- Citations by year
- 2024: 1 · 2021: 3 · 2018: 2 · 2016: 2 · 2015: 2 · 2014: 1 · 2013: 5 · 2012: 2
- FWCI
- 0.39
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Biotechnology Letters (publishedVersion)
- Topics
- Health Sciences › Medicine › Pharmacology › Microbial Natural Products and Biosynthesis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Microbial Metabolic Engineering and Bioproduction
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biotechnology › Enzyme Production and Characterization
- Keywords
- clavulanic acid, Streptomyces clavuligerus, glycerol feeding, fed-batch fermentation, antibiotic production, carbon source supplementation, product stability, shake flask culture
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
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