Cited by 38Microbial Natural Products and BiosynthesisMicrobial Metabolic Engineering and BioproductionEnzyme Production and Characterization

Optimization of glycerol feeding for clavulanic acid production by Streptomyces clavuligerus with glycerol feeding

Chen, Kuo-Cheng, Lin, Yun-Huin, Tsai, Cheng-Min, Hsieh, Chen-Hao, Houng, Jer-Yiing·2002·Biotechnology Letters

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Crossref · 10.1023/a:1014553109425

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1 of 1 references verified0 citation errors · 0 not checkable

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  • Comparing batch and fed-batch fermentation, fed-batch fermentation systems seemed to generate a higher yield of clavulanic acid.

    “Comparing batch and fed-batch fermentation, fed-batch fermentation systems seemed to generate a higher yield of clavulanic acid (Chen et al., 2002; Neto et al., 2005; Bellão et al., 2013).”
  • Glycerol shows a biphasic dose response, with clavulanic acid production inhibited at concentrations that are either too high or too low.

    “Additionally, two other studies by Chen et al. (2002) and Saudagar and Singhal (2007a) revealed a biphasic dose response of glycerol; whereby clavulanic acid production was inhibited at concentrations which were either too high or too low.”

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Authors
Chen, K.-C., Lin, Y.-H., Tsai, C.-M., Hsieh, C.-H., & Houng, J.-Y.
Affiliations
  • National Tsing Hua University (TW)
  • I-Shou University (TW)
Corresponding author
Chen, Kuo-Cheng
Venue
Biotechnology Letters
Published
2002-03
Volume
24
Issue
6
Pages
455-458
ISSN
  • 0141-5492 (ISSN-L)
  • 1573-6776
OpenAlex
W2253845724
Cited by
38
References
1
Citations by year
2024: 1 · 2021: 3 · 2018: 2 · 2016: 2 · 2015: 2 · 2014: 1 · 2013: 5 · 2012: 2
FWCI
0.39
Type
journal article
Language
en
Open access
closed
Locations
Biotechnology Letters (publishedVersion)
Topics
  • Health Sciences › Medicine › Pharmacology › Microbial Natural Products and Biosynthesis
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Microbial Metabolic Engineering and Bioproduction
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Biotechnology › Enzyme Production and Characterization
Keywords
clavulanic acid, Streptomyces clavuligerus, glycerol feeding, fed-batch fermentation, antibiotic production, carbon source supplementation, product stability, shake flask culture

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