The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.
Telomerase activity in ductal carcinoma in situ of the breast
Abstract
Telomerase plays an important role in maintaining the stability of the chromosomes. Activity of telomerase has been detected in proliferating and immortalized cell lines and in a number of malignant tumors including invasive breast cancer. The aim of the study was to examine telomerase activity in ductal carcinoma in situ (DCIS), which is considered to be a precursor lesion of infiltrating breast carcinoma, using a PCR-based telomerase activity protocol (TRAP). We examined 35 samples obtained from histologically confirmed breast biopsies, including 13 normal breast tissues, 11 infiltrating ductal carcinoma (IDC), nine DCIS, and two DCIS with microinvasion. Telomerase activity was demonstrated in 8/9 samples of DCIS, both samples of DCIS with microinvasion, and all but one sample of IDC. Normal breast tissue had no demonstrable telomerase activity. Our results indicate that telomerase is activated frequently in early breast carcinogenesis, although its utilization as a biomarker in DCIS is questionable.
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“Pre-invasive cancers of the bladder, cervix, colon, esophagus and oral cavity were also shown to have very short telomeres in 89% of cases studied.”
From Telomeres and telomerase in cancer (2010) · cites this paper as [127]
In the citing paper
“These data indicate that telomeres shorten during epithelial cancer development in humans and that short telomeres are evident at the earliest stages of human carcinogenesis (127,128).”
From Telomeres and telomerase in cancer (2010) · cites this paper as [127]
Citations
Cites
Specific Association of Human Telomerase Activity with Immortal Cells and Cancer
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“High telomerase activity has been associated with immortal cells, cancers as well as rapidly-proliferating cells [18, 30, 31].”
BackgroundA survey of telomerase activity in human cancer
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Telomerase Activity in Human Breast Tumors
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Sorted by citations
Telomere dysfunction promotes non-reciprocal translocations and epithelial cancers in mice
Artandi, S. E., Chang, S., Lee, S.-L., Alson, S., Gottlieb, G. J., Chin, L., & DePinho, R. A. (2000) · Nature · doi:10.1038/35020592 · Cited by 1,085
Human breast cancer cells generated by oncogenic transformation of primary mammary epithelial cells
Elenbaas, B., Spirio, L., Koerner, F., Fleming, M. D., Zimonjic, D. B., Donaher, J. L., Popescu, N. C., Hahn, W. C., & Weinberg, R. A. (2001) · Genes & Development · doi:10.1101/gad.828901 · Cited by 878
Telomeres and telomerase in cancer
Artandi, S. E., & DePinho, R. A. (2010) · Carcinogenesis · doi:10.1093/carcin/bgp268 · Cited by 823
Constitutive telomerase expression promotes mammary carcinomas in aging mice
Artandi, S. E., Alson, S., Tietze, M. K., Sharpless, N. E., Ye, S., Greenberg, R. A., Castrillon, D. H., Horner, J. W., Weiler, S. R., Carrasco, R. D., et al. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.112515399 · Cited by 317
Proteomics of human breast ductal carcinoma in situ.
Wulfkuhle, J. D., Sgroi, D. C., Krutzsch, H. C., McLean, K. C., McGarvey, K. M., Knowlton, M., Chen, S., Shu, H., Şahin, A. A., Kurek, R., et al. (2002) · PubMed · Cited by 256
Metadata
- Authors
- Shpitz, B., Zimlichman, S., Zemer, R., Bomstein, Y., Zehavi, T., Liverant, S., Bernehim, J., Kaufman, Z., Klein, E., Shapira, Y., & Klein, A. P.
- Venue
- Breast Cancer Research and Treatment
- Published
- 1999-11
- Volume
- 58
- Issue
- 1
- Pages
- 65-69
- ISSN
- 0167-6806 (ISSN-L)
- 1573-7217
- OpenAlex
- W2072899803
- Cited by
- 46
- References
- 33
- Citations by year
- 2025: 1 · 2024: 2 · 2023: 2 · 2018: 2 · 2017: 1 · 2016: 3 · 2015: 1 · 2013: 2
- FWCI
- 1.49
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Breast Cancer Research and Treatment (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Telomeres, Telomerase, and Senescence
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Breast Cancer Treatment Studies
- Health Sciences › Medicine › Pathology and Forensic Medicine › Breast Lesions and Carcinomas
- Keywords
- telomerase activity, ductal carcinoma in situ, breast cancer, invasive ductal carcinoma, microinvasion, TRAP assay, chromosome stability
- MeSH terms
- Adult, Aged, Breast, Breast Neoplasms, Carcinoma, Intraductal, Noninfiltrating, Female, Humans, Immunohistochemistry, Middle Aged, Neoplasm Invasiveness, Polymerase Chain Reaction, Carcinoma, Ductal, Breast, Telomerase
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- The paper
- Shpitz, B., Zimlichman, S., Zemer, R., Bomstein, Y., Zehavi, T., Liverant, S., Bernehim, J., Kaufman, Z., Klein, E., Shapira, Y., & Klein, A. P. (1999). Telomerase activity in ductal carcinoma in situ of the breast. Breast Cancer Research and Treatment. https://doi.org/10.1023/a%3A1006394209922
