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Cited by 41Pituitary Gland Disorders and TreatmentsAdrenal Hormones and DisordersElectrolyte and hormonal disorders

The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.

Effect of the serotonin antagonists ritanserin and ketanserin in Cushing’s disease

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Sonino, Nicoletta, Fava, Giovanni A., Fallo, Francesco, Franceschetto, Antonella, Belluardo, Piera, Boscaro, Marco·2000·Pituitary
DOI 10.1023/a:1009986822146
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Abstract

Central serotonergic regulation could have a role in the course of pituitary-dependent Cushing's disease. We studied the effects of ritanserin and ketanserin, two related selective 5HT2 receptor antagonists, in 11 patients with Cushing's disease. Treatment lasted from 1 month to 1 year (up to 4 years in one patient). Daily doses were 10-15 mg for ritanserin, and 40-80 mg for ketanserin. Since the two drugs share the same mechanism of action and no qualitative or quantitative differences in response to their administration were observed, the results were pooled together. Patients were assessed by clinical and hormonal evaluation. Urinary cortisol and ACTH were considered the parameters of interest. Short-term response: after 1 month, there was a significant decrease of urinary cortisol from 781 (160) to 331 (215) nmol/d (P < 0.02) while ACTH was 9.8 (1.5) pmol/L baseline and again 8.8 (2.2) pmol/L at 1 month (P = NS). For 9 patients, hormonal parameters were available after 1 week of treatment. In this case, also ACTH levels were significantly decreased (from 9.6 (1.7) to 5.2 (1.3) pmol/L; P < 0.01) together with urinary cortisol (from 781 (194) to 372 (165) nmol/d; P < 0.01). Long-term response: in 3 patients, hormonal parameters failed to respond to serotonin receptor antagonists, which were thus discontinued. An improvement was recorded in the remaining 8 patients, that was prolonged in 3, and transient in 5. In 3 of these latter patients, a marked increase of ACTH was observed before treatment discontinuation. Ketanserin was given to 2 patients with Nelson's syndrome, with only transient ACTH decrease in one, and no changes in ACTH response to CRH after 1 month treatment in both cases. An inhibitory effect of ritanserin and ketanserin on ACTH and cortisol production in Cushing's disease appeared to be limited both in terms of duration of response and number of patients with a satisfactory outcome. However, the results may provide a better understanding of serotonergic modulation in Cushing's disease and lead to therapeutic developments.

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Crossref · 10.1023/a:1009986822146

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Metadata

Authors
Sonino, N., Fava, G. A., Fallo, F., Franceschetto, A., Belluardo, P., & Boscaro, M.
Affiliations
  • University of Padua (IT)
  • University at Buffalo, State University of New York (US)
ORCID
Venue
Pituitary
Publisher
Springer Science and Business Media LLC
Published
2000-10
Volume
3
Issue
2
Pages
55-59
ISSN
  • 1386-341X (ISSN-L)
  • 1573-7403
DOI
10.1023/a:1009986822146
OpenAlex
W130491512
Cited by
41
References
39
Citations by year
2023: 1 · 2022: 1 · 2020: 1 · 2018: 4 · 2017: 1 · 2016: 2 · 2015: 4 · 2013: 2
FWCI
1.94
Type
journal article
Language
en
Open access
Licence
Locations
  • Pituitary (publishedVersion)
  • PubMed (publishedVersion)
  • IRIS UNIMORE (University of Modena and Reggio Emilia) (submittedVersion, cc-by)
  • Padua Research Archive (University of Padova) (submittedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pituitary Gland Disorders and Treatments
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
  • Health Sciences › Medicine › Nephrology › Electrolyte and hormonal disorders
Keywords
Cushing's disease, ritanserin, ketanserin, 5-HT2 receptor antagonist, serotonin, ACTH, urinary cortisol, Nelson's syndrome, serotonergic regulation, pituitary-dependent Cushing's disease, drug response
MeSH terms
Adolescent, Adrenocorticotropic Hormone, Adult, Cushing Syndrome, Female, Hormones, Humans, Hydrocortisone, Ketanserin, Long-Term Care, Male, Middle Aged, Nelson Syndrome, Serotonin Antagonists, Ritanserin

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