Stealth PLA-PEG nanoparticles as protein carriers for nasal administration
Abstract
Purpose The aim of the study was to encapsulate a model protein antigen, tetanus toxoid (TT), within hydrophobic (PLA) and surface hydrophilic (PLA-PEG) nanoparticles and to evaluate the potential of these colloidal carriers for the transport of proteins through the nasal mucosa. Methods TT-loaded nanoparticles, prepared by a modified water-in-oil-in-water solvent evaporation technique, were characterized in their size, zeta potential and hydrophobicity. Nanoparticles were also assayed in vitro for their ability to deliver active antigen for extended periods of time. Finally, 125I-TT-loaded nanoparticles were administered intranasally to rats and the amount of radioactivity recovered in the blood compartment, lymph nodes and other relevant tissues was monitored for up to 48 h. Results PLA and PLA-PEG nanoparticles had a similar particle size (137-156 nm) and negative surface charge, but differed in their surface hydrophobicity: PLA were more hydrophobic than PLA-PEG nanoparticles. PLA-PEG nanoparticles, especially those containing gelatine as an stabilizer, provided extended delivery of the active protein. The transport of the radiolabeled protein through the rat nasal mucosa was highly affected by the surface properties of the nanoparticles: PLA-PEG nanoparticles led to a much greater penetration of TT into the blood circulation and the lymph nodes than PLA nanoparticles. Furthermore, after administration of 125I-TT-loaded PLA-PEG nanoparticles, it was found that a high amou…
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The PEG layer acts as a barrier, reducing interactions with foreign molecules through steric and hydrated repulsion, which improves shelf stability.
“This layer of PEG acts as a barrier and reduces the interactions with foreign molecules by steric and hydrated repulsion, giving enhanced shelf stability [22].”
From Poly Lactic-co-Glycolic Acid (PLGA) as Biodegradable Controlled Drug Delivery Carrier (2011) · cites this paper as [22]
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- Authors
- Tobío, M., Gref, R., Sánchez, A., Langer, R., & Alonso, M. J.
- Affiliations
- Universidade de Santiago de Compostela (ES)
- Laboratoire de Chimie-Physique Macromoléculaire (FR)
- Massachusetts Institute of Technology (US)
- Venue
- Pharmaceutical Research
- Published
- 1998-02
- Volume
- 15
- Issue
- 2
- Pages
- 270-275
- ISSN
- 0724-8741 (ISSN-L)
- 1573-904X
- OpenAlex
- W1494872149
- Cited by
- 402
- References
- 19
- Citations by year
- 2026: 4 · 2025: 7 · 2024: 10 · 2023: 9 · 2022: 4 · 2021: 6 · 2020: 7 · 2019: 15 · 2018: 14 · 2017: 15 · 2016: 22 · 2015: 13 · 2014: 25 · 2013: 24 · 2012: 31
- FWCI
- 10.43
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Pharmaceutical Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of General Medical Sciences (R01GM026698, GM 26698)
- Topics
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Inhalation and Respiratory Drug Delivery
- Keywords
- polylactic acid, protein encapsulation, tetanus toxoid, nasal mucosa, intranasal drug delivery, carrier proteins, surface hydrophobicity, lymph node uptake, blood circulation, colloidal carriers
- MeSH terms
- Administration, Intranasal, Animals, Drug Carriers, Lactates, Microscopy, Electron, Particle Size, Polyethylene Glycols, Tetanus Toxoid, Tissue Distribution, Rats
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