Chemical aspects of siderophore mediated iron transport

Boukhalfa, Hakim; Crumbliss, Alvin L.

doi:10.1023/a:1020218608266

Cited by 568Iron Metabolism and DisordersInorganic and Organometallic ChemistryBacterial Genetics and Biotechnology

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Chemical aspects of siderophore mediated iron transport

Boukhalfa, Hakim, Crumbliss, Alvin L.·2002·Biometals

DOI 10.1023/a:1020218608266

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Abstract

In this mini-review we describe selected aspects of the coordination chemistry relevant to siderophore mediated iron transport and bioavailability. Specific emphasis is placed on a discussion of in vitro kinetic and thermodynamic data that are relevant to elucidating possible in vivo mechanisms for environmental iron acquisition by microbial cells.

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Bacteria and fungi solved problems of iron solubility and toxicity by creating and excreting siderophores, which have extremely tight binding constants (Kf > 10^30) and can solubilise and sequester iron.
“Consequently, and because these reflect fundamental physicochemical properties of such ions, the problems of both solubility and toxicity were faced by bacteria (and indeed fungi [166-169]) long ago in evolution, and were solved by their creation and excretion of (mainly ferric-)iron chelators known as siderophores [170-189] (and for haemophores see [190]). These typically have extremely tight b”
From Iron behaving badly: inappropriate iron chelation as a major contributor to the aetiology of vascular and other progressive inflammatory and degenerative diseases (2009) · cites this paper as [175]

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Authors: Boukhalfa, H., & Crumbliss, A. L.
Affiliations: Duke University (US)
Corresponding author: Crumbliss, Alvin L.
ORCID: Boukhalfa, Hakim
Crumbliss, Alvin L.
Venue: Biometals
Publisher: Springer Science and Business Media LLC
Published: 2002-12
Volume: 15
Issue: 4
Pages: 325-339
ISSN: 0966-0844 (ISSN-L)
1572-8773
DOI: 10.1023/a:1020218608266
OpenAlex: W1657518708
Cited by: 547
References: 74
Citations by year: 2026: 7 · 2025: 14 · 2024: 21 · 2023: 27 · 2022: 22 · 2021: 24 · 2020: 32 · 2019: 27 · 2018: 25 · 2017: 34 · 2016: 26 · 2015: 28 · 2014: 32 · 2013: 18 · 2012: 27
FWCI: 2.35
Type: journal article
Language: en
Open access: closed
Licence: www.springernature.com/gp/researchers/text-and-data-mining (tdm)
www.springernature.com/gp/researchers/text-and-data-mining (vor)
Locations: BioMetals (publishedVersion)
PubMed (publishedVersion)
Funders: National Science Foundation
Topics: Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
Physical Sciences › Chemistry › Inorganic Chemistry › Inorganic and Organometallic Chemistry
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
Keywords: siderophores, iron transport, iron acquisition, coordination chemistry, bioavailability, thermodynamics, kinetics, metal complexes
MeSH terms: Animals, Deferoxamine, Ferric Compounds, Humans, Hydrogen-Ion Concentration, Iron, Kinetics, Ligands, Oxidation-Reduction, Peptides, Cyclic, Solubility, Siderophores

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Chemical aspects of siderophore mediated iron transport

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