The DOI matches its Crossref record; 73 of the 74 references it cites were found in a registry or an index.
Modular Assembly of Genes and the Evolution of New Functions
Abstract
Modular assembly of novel genes from existing genes has long been thought to be an important source of evolutionary novelty. Thanks to major advances in genomic studies it has now become clear that this mechanism contributed significantly to the evolution of novel biological functions in different evolutionary lineages. Analyses of completely sequenced bacterial, archaeal and eukaryotic genomes has revealed that modular assembly of novel constituents of various eukaryotic intracellular signalling pathways played a major role in the evolution of eukaryotes. Comparison of the genomes of single-celled eukaryotes, multicellular plants and animals has also shown that the evolution of multicellularity was accompanied by the assembly of numerous novel extracellular matrix proteins and extracellular signalling proteins that are absolutely essential for multicellularity. There is now strong evidence that exon-shuffling played a general role in the assembly of the modular proteins involved in extracellular communications of metazoa. Although some of these proteins seem to be shared by all major groups of metazoa, others are restricted to certain evolutionary lineages. The genomic features of the chordates appear to have favoured intronic recombination as evidenced by the fact that exon-shuffling continued to be a major source of evolutionary novelty during vertebrate evolution.
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“Shuffling events are especially prevalent in metazoans, where complex exon–intron structures and the abundance of recombination-competent elements enhance the plasticity of gene architectures [21,22].”
From Origin and Evolution of Genes in Eukaryotes: Mechanisms, Dynamics, and Functional Implications (2025) · cites this paper as [22]
Citations
Cites
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Research works printed but not linked: 1
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Cited by
TopHat: discovering splice junctions with RNA-Seq
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The Toxicogenomic Multiverse: Convergent Recruitment of Proteins Into Animal Venoms
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The evolution of spliceosomal introns: patterns, puzzles and progress
William Roy, S., & Gilbert, W. (2006) · Nature Reviews Genetics · doi:10.1038/nrg1807 · Cited by 648
Molluscan Shell Proteins: Primary Structure, Origin, and Evolution
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Origin and evolution of spliceosomal introns
Rogozin, I. B., Carmel, L., Csuros, M., & Koonin, E. V. (2012) · Biology Direct · doi:10.1186/1745-6150-7-11 · Cited by 415
Metadata
- Authors
- Patthy, L.
- Affiliations
- Institute of Molecular Life Sciences (HU)
- Corresponding author
- Patthy, László
- ORCID
- Patthy, László
- Venue
- Genetica
- Published
- 2003-07
- Volume
- 118
- Issue
- 2-3
- Pages
- 217-231
- ISSN
- 0016-6707 (ISSN-L)
- 1573-6857
- OpenAlex
- W1570477334
- Cited by
- 166
- References
- 74
- Citations by year
- 2025: 3 · 2024: 4 · 2023: 1 · 2022: 1 · 2021: 3 · 2020: 3 · 2019: 7 · 2018: 3 · 2017: 8 · 2016: 6 · 2015: 5 · 2014: 7 · 2013: 12 · 2012: 8
- FWCI
- 15.06
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springernature.com/gp/researchers/text-and-data-mining (tdm)
- www.springernature.com/gp/researchers/text-and-data-mining (vor)
- Locations
- Genetica (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Chromosomal and Genetic Variations
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Evolution and Genetic Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Phylogenetic Studies
- Keywords
- gene birth, exon shuffling, intracellular signaling, extracellular matrix proteins, evolution of multicellularity, chordate evolution, vertebrate evolution, animals, eukaryotic evolution
- MeSH terms
- Exons, Genes, Introns, Proteins, Genome, Evolution, Molecular
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
