Cited by 167Chromosomal and Genetic VariationsEvolution and Genetic DynamicsGenomics and Phylogenetic Studies

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Modular Assembly of Genes and the Evolution of New Functions

Patthy, László·2003·Genetica

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Abstract

Modular assembly of novel genes from existing genes has long been thought to be an important source of evolutionary novelty. Thanks to major advances in genomic studies it has now become clear that this mechanism contributed significantly to the evolution of novel biological functions in different evolutionary lineages. Analyses of completely sequenced bacterial, archaeal and eukaryotic genomes has revealed that modular assembly of novel constituents of various eukaryotic intracellular signalling pathways played a major role in the evolution of eukaryotes. Comparison of the genomes of single-celled eukaryotes, multicellular plants and animals has also shown that the evolution of multicellularity was accompanied by the assembly of numerous novel extracellular matrix proteins and extracellular signalling proteins that are absolutely essential for multicellularity. There is now strong evidence that exon-shuffling played a general role in the assembly of the modular proteins involved in extracellular communications of metazoa. Although some of these proteins seem to be shared by all major groups of metazoa, others are restricted to certain evolutionary lineages. The genomic features of the chordates appear to have favoured intronic recombination as evidenced by the fact that exon-shuffling continued to be a major source of evolutionary novelty during vertebrate evolution.

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Authors: Patthy, L.
Affiliations: Institute of Molecular Life Sciences (HU)
Corresponding author: Patthy, László
ORCID: Patthy, László
Venue: Genetica
Publisher: Springer Science and Business Media LLC
Published: 2003-07
Volume: 118
Issue: 2-3
Pages: 217-231
ISSN: 0016-6707 (ISSN-L)
1573-6857
DOI: 10.1023/a:1024182432483
OpenAlex: W1570477334
Cited by: 166
References: 74
Citations by year: 2025: 3 · 2024: 4 · 2023: 1 · 2022: 1 · 2021: 3 · 2020: 3 · 2019: 7 · 2018: 3 · 2017: 8 · 2016: 6 · 2015: 5 · 2014: 7 · 2013: 12 · 2012: 8
FWCI: 15.06
Type: journal article
Language: en
Open access: closed
Licence: www.springernature.com/gp/researchers/text-and-data-mining (tdm)
www.springernature.com/gp/researchers/text-and-data-mining (vor)
Locations: Genetica (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Chromosomal and Genetic Variations
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Evolution and Genetic Dynamics
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Phylogenetic Studies
Keywords: gene birth, exon shuffling, intracellular signaling, extracellular matrix proteins, evolution of multicellularity, chordate evolution, vertebrate evolution, animals, eukaryotic evolution
MeSH terms: Exons, Genes, Introns, Proteins, Genome, Evolution, Molecular

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Modular Assembly of Genes and the Evolution of New Functions

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