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Effects of adsorbed heat labile serum proteins and fibrinogen on adhesion and apoptosis of monocytes/macrophages on biomaterials
Abstract
A previously established human monocyte culture protocol was used to determine the effects of varying adsorbed proteins on monocyte/macrophage adhesion and survival on dimethyl-silane (DM) or RGD modified glass coverslips. Cells were allowed to adhere for 2 h in the absence of protein or in the presence of serum, fibrinogen (Fg), heat inactivated serum (HIS), serum supplemented with Fg or HIS with Fg. Cell adhesion and apoptosis rates were determined on days 0 (2 h), 3, 7 and 10 of culture. The presence of serum alone in the initial culture was sufficient to optimize monocyte/macrophage adhesion and survival rates. Adding Fg to serum did not increase adhesion nor decrease apoptotic rates. No protein or the addition of HIS during the initial incubation period significantly decreased monocyte/macrophage adhesion and survival on both surfaces, however, the addition of Fg to HIS restored adhesion and survival rates to those seen with in the presence of serum alone on RGD surfaces. These studies demonstrate that monocyte/macrophage adhesion and survival on biomaterial surfaces are optimized by adsorbed heat labile serum proteins while adsorbed Fg plays a surface property-dependent role.
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Biomaterial surface chemistry influences apoptosis of adherent macrophages both in vitro and in vivo.
“Biomaterial surface chemistry influences apoptosis of adherent macrophages both in vitro and in vivo.[12, 53–55]”
From Foreign body reaction to biomaterials (2008) · cites this paper as [12]
The presence of adsorbed proteins such as albumin, fibrinogen, complement, fibronectin, vitronectin, γ globulin, and others modulate host inflammatory cell interactions and adhesion and are linked to subsequent inflammatory and wound healing responses.
“The presence of adsorbed proteins such as albumin, fibrinogen, complement, fibronectin, vitronectin, γ globulin, and others modulate host inflammatory cell interactions and adhesion and thus are linked to subsequent inflammatory and wound healing responses.[11–14]”
From Foreign body reaction to biomaterials (2008) · cites this paper as [12]
Initial monocyte adhesion is achieved through β2 integrins, in particular αM/β2 (Mac-1, CD11b/CD18), by binding to various adsorbed protein ligands including fibrinogen, fibronectin, IgG, and complement fragment iC3b.
“Initial monocyte adhesion is achieved through β2 integrins, in particular αM/β2(Mac-1, CD11b/CD18), by binding to various adsorbed protein ligands including fibrinogen, fibronectin, IgG, and complement fragment iC3b.[12, 29]”
From Foreign body reaction to biomaterials (2008) · cites this paper as [12]
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Metadata
- Authors
- Brodbeck, W. G., Colton, E., & Anderson, J. M.
- Affiliations
- Case Western Reserve University (US)
- Corresponding author
- Brodbeck, William G.
- ORCID
- Anderson, James M.
- Venue
- Journal of Materials Science Materials in Medicine
- Published
- 2003-08
- Volume
- 14
- Issue
- 8
- Pages
- 671-675
- ISSN
- 0957-4530 (ISSN-L)
- 1573-4838
- OpenAlex
- W332874279
- Cited by
- 65
- References
- 17
- Citations by year
- 2025: 2 · 2024: 1 · 2023: 2 · 2021: 4 · 2020: 2 · 2019: 5 · 2018: 2 · 2017: 1 · 2016: 4 · 2015: 4 · 2014: 3 · 2013: 5 · 2012: 3
- FWCI
- 1.24
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Journal of Materials Science Materials in Medicine (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- Topics
- Physical Sciences › Materials Science › Surfaces, Coatings and Films › Polymer Surface Interaction Studies
- Health Sciences › Medicine › Immunology and Allergy › Cell Adhesion Molecules Research
- Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
- Keywords
- apoptosis, fibrinogen, protein adsorption, biomaterial surfaces, heat-inactivated serum, surface modification, cell survival
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