Cited by 318Orthopaedic implants and arthroplastyPolymer Surface Interaction StudiesBone Tissue Engineering Materials

Foreign‐body giant cells and polyurethane biostability: In vivo correlation of cell adhesion and surface cracking

Zhao, Q., Topham, N., Anderson, J. M., Hiltner, A., Lodoen, G., Payet, C. R.·1991·Journal of Biomedical Materials Research

Integrity signals

Registry

Crossref · 10.1002/jbm.820250205

Cites

15 of 15 references verified0 citation errors · 0 not checkable

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Claims the paper makes

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Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Sensor films and membranes are prone to degradation from oxidative challenges, calcification, and delamination.

    “These materials are prone to degradation from oxidative challenges (i.e., foreign body response), calcification, and delamination.73”
  • As the foreign body response progresses, frustrated phagocytosis from activated macrophages leads to fusion into foreign body giant cells that attempt to further break down the implant.

    “As the FBR progresses, frustrated phagocytosis from activated macrophages will lead to the fusion of macrophages into foreign body giant cells (FBGCs) that attempt to further breakdown the implant.73,94,97–98”
  • Foreign body giant cell formation on polyurethanes promotes cracking of the underlying biomaterial.

    “For example, FBGC formation on polyurethanes has been shown to promote cracking of the underlying biomaterial.73”

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Authors
Zhao, Q., Topham, N., Anderson, J. M., Hiltner, A., Lodoen, G., & Payet, C. R.
Affiliations
  • Case Western Reserve University (US)
  • DuPont (United States) (US)
Corresponding author
Anderson, J. M.
Venue
Journal of Biomedical Materials Research
Publisher
Wiley
Published
1991-02
Volume
25
Issue
2
Pages
177-183
ISSN
  • 0021-9304 (ISSN-L)
  • 1097-4636
OpenAlex
W2032478134
Cited by
318
References
15
Citations by year
2026: 2 · 2025: 4 · 2024: 6 · 2023: 2 · 2022: 5 · 2021: 5 · 2020: 13 · 2019: 7 · 2018: 5 · 2017: 11 · 2016: 8 · 2015: 8 · 2014: 8 · 2013: 8 · 2012: 11
FWCI
12.88
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Biomedical Materials Research (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Heart, Lung, and Blood Institute (HL25239, HL-33829, R01HL025239)
Topics
  • Health Sciences › Medicine › Surgery › Orthopaedic implants and arthroplasty
  • Physical Sciences › Materials Science › Surfaces, Coatings and Films › Polymer Surface Interaction Studies
  • Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
Keywords
foreign body giant cells, polyurethane, biostability, cell adhesion, surface cracking, biodegradation
MeSH terms
Animals, Biocompatible Materials, Cell Adhesion, Female, Foreign Bodies, Microscopy, Electron, Scanning, Polyurethanes, Rats, Inbred Strains, Giant Cells, Rats

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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

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