Foreign‐body giant cells and polyurethane biostability: In vivo correlation of cell adhesion and surface cracking
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Sensor films and membranes are prone to degradation from oxidative challenges, calcification, and delamination.
“These materials are prone to degradation from oxidative challenges (i.e., foreign body response), calcification, and delamination.73”
From Biocompatible Materials for Continuous Glucose Monitoring Devices (2013) · cites this paper as [73]
As the foreign body response progresses, frustrated phagocytosis from activated macrophages leads to fusion into foreign body giant cells that attempt to further break down the implant.
“As the FBR progresses, frustrated phagocytosis from activated macrophages will lead to the fusion of macrophages into foreign body giant cells (FBGCs) that attempt to further breakdown the implant.73,94,97–98”
From Biocompatible Materials for Continuous Glucose Monitoring Devices (2013) · cites this paper as [73]
Foreign body giant cell formation on polyurethanes promotes cracking of the underlying biomaterial.
“For example, FBGC formation on polyurethanes has been shown to promote cracking of the underlying biomaterial.73”
From Biocompatible Materials for Continuous Glucose Monitoring Devices (2013) · cites this paper as [73]
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Biomaterials: Foreign Bodies or Tuners for the Immune Response?
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- Authors
- Zhao, Q., Topham, N., Anderson, J. M., Hiltner, A., Lodoen, G., & Payet, C. R.
- Affiliations
- Case Western Reserve University (US)
- DuPont (United States) (US)
- Corresponding author
- Anderson, J. M.
- ORCID
- Anderson, J. M.
- Venue
- Journal of Biomedical Materials Research
- Publisher
- Wiley
- Published
- 1991-02
- Volume
- 25
- Issue
- 2
- Pages
- 177-183
- ISSN
- 0021-9304 (ISSN-L)
- 1097-4636
- OpenAlex
- W2032478134
- Cited by
- 318
- References
- 15
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 6 · 2023: 2 · 2022: 5 · 2021: 5 · 2020: 13 · 2019: 7 · 2018: 5 · 2017: 11 · 2016: 8 · 2015: 8 · 2014: 8 · 2013: 8 · 2012: 11
- FWCI
- 12.88
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Biomedical Materials Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Heart, Lung, and Blood Institute (HL25239, HL-33829, R01HL025239)
- Topics
- Health Sciences › Medicine › Surgery › Orthopaedic implants and arthroplasty
- Physical Sciences › Materials Science › Surfaces, Coatings and Films › Polymer Surface Interaction Studies
- Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
- Keywords
- foreign body giant cells, polyurethane, biostability, cell adhesion, surface cracking, biodegradation
- MeSH terms
- Animals, Biocompatible Materials, Cell Adhesion, Female, Foreign Bodies, Microscopy, Electron, Scanning, Polyurethanes, Rats, Inbred Strains, Giant Cells, Rats
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