Human plasma α2‐macroglobulin promotes in vitro oxidative stress cracking of pellethane 2363‐80A: In vivo and in vitro correlations
Abstract
It is hypothesized in this study that the phenomenon of environmental stress cracking (ESC) in polyetheruethane is caused by a synergistic action of biological components in the body fluids, oxidative agents, and stress. An in vitro system is designed to mimic the in vivo system; human plasma contains certain biological components that can act as a stress cracking promoter, while H 2 O 2 (Co) solution provides an oxidative reaction comparable to that observed in the respiratory burst of adherent macrophages and foreign‐body giant cells. It is demonstrated that the phenomenon of in vivo stress cracking in Pellethane 2363‐80A is duplicated by an in vitro system that involves a pretreatment of prestressed specimens with human plasma at 37°C for 7 days followed by oxidation in 10% hydrogen peroxide with 0.10M cobalt chloride at 50°C for 10 days. The pretreatment with plasma has a synergistic effect with the oxidation by H 2 O 2 (Co) treatment to produce ESC. A plasma component responsible for promoting stress cracking in Pellethane polyurethane is identified to be α 2‐macroglobulin (α 2 M). © 1993 John Wiley & Sons, Inc.
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The soft segment of polyether polyurethanes is known to undergo degradation.
“The soft segment of polyether polyurethanes is known to undergo degradation.[86–98]”
From Foreign body reaction to biomaterials (2008) · cites this paper as [86]
There is an in vivo correlation between macrophage and foreign body giant cell adhesion and environmental stress cracking on the surface of the material.
“In this study and others, we clearly identified the in vivo correlation between macrophage and FBGC adhesion and environmental stress cracking on the surface of the material.[86, 87]”
From Foreign body reaction to biomaterials (2008) · cites this paper as [86]
As the foreign body response progresses, frustrated phagocytosis from activated macrophages leads to fusion into foreign body giant cells that attempt to further break down the implant.
“As the FBR progresses, frustrated phagocytosis from activated macrophages will lead to the fusion of macrophages into foreign body giant cells (FBGCs) that attempt to further breakdown the implant.73,94,97–98”
From Biocompatible Materials for Continuous Glucose Monitoring Devices (2013) · cites this paper as [94]
The foreign body response can cause local pH to drop as low as 3.6, disrupting biosensor performance because glucose oxidase activity is pH dependent.
“This process can result in a local pH’s dropping as low as 3.6 and disrupting biosensor performance as the activity of GOx is pH dependent.94”
From Biocompatible Materials for Continuous Glucose Monitoring Devices (2013) · cites this paper as [94]
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- Authors
- Zhao, Q. H., McNally, A. K., Rubin, K. R., Renier, M., Wu, Y., Rose‐Caprara, V., Anderson, J. M., Hiltner, A., Urbanski, P., & Stokes, K.
- Affiliations
- Case Western Reserve University (US)
- Medtronic (United States) (US)
- Corresponding author
- Anderson, J. M.
- Venue
- Journal of Biomedical Materials Research
- Publisher
- Wiley
- Published
- 1993-03
- Volume
- 27
- Issue
- 3
- Pages
- 379-388
- ISSN
- 0021-9304 (ISSN-L)
- 1097-4636
- OpenAlex
- W1968687065
- Cited by
- 140
- References
- 16
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 4 · 2023: 2 · 2022: 2 · 2021: 2 · 2020: 2 · 2019: 5 · 2018: 4 · 2017: 5 · 2016: 7 · 2015: 3 · 2014: 5 · 2013: 4 · 2012: 2
- FWCI
- 7.30
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Biomedical Materials Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Materials Science › Surfaces, Coatings and Films › Polymer Surface Interaction Studies
- Health Sciences › Medicine › Surgery › Orthopaedic implants and arthroplasty
- Physical Sciences › Materials Science › Biomaterials › biodegradable polymer synthesis and properties
- Keywords
- alpha2-macroglobulin, environmental stress cracking, polyether polyurethane, oxidative stress, hydrogen peroxide oxidation, cobalt chloride, human plasma, in vitro-in vivo correlation, foreign body giant cells, macrophage respiratory burst, biomaterial degradation
- MeSH terms
- alpha-Macroglobulins, Animals, Body Fluids, Fourier Analysis, Humans, Microscopy, Electron, Scanning, Oxidation-Reduction, Polyurethanes, Spectrophotometry, Infrared, Stress, Mechanical, Surface Properties, Rats, Sprague-Dawley, Rats
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