Brief report: Case reports on naltrexone use in children with autism: Controlled observations regarding benefits and practical issues of medication management
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Observational studies in patients with autism have shown that administration of an opioid antagonist could decrease self-injurious behavior, stereotypies, hyperactivity, and withdrawal, while increasing verbal production, social communication, proximity seeking, and eye contact.
“Observational studies in patients with autism have shown that administration of an opioid antagonist could decrease self-injurious behavior, stereotypies, hyperactivity, and withdrawal, although increasing verbal production, social communication, proximity seeking, and eye contact (47–50).”
From Oxytocin under opioid antagonism leads to supralinear enhancement of social attention (2017) · cites this paper as [50]
Cites
Diagnostic and Statistical Manual of Mental Disorders
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A neurochemical theory of autism
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Autism and Known Medical Conditions: Myth and Substance
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Naltrexone in autistic children: Behavioral symptoms and attentional learning
CAMPBELL, M., ANDERSON, L. T., SMALL, A. M., ADAMS, P., GONZALEZ, N. M., & ERNST, M. (1993) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/00004583-199311000-00024 · Cited by 210 · see citing works
Effects of naloxone and naltrexone on self-injury: a double-blind, placebo-controlled analysis.
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Naltrexone in Young Autistic Children: Replication Study and Learning Measures
Kolmen, B. K., Feldman, H. M., Handen, B. L., & Janosky, J. E. (1997) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1016/s0890-8567(09)66567-9 · Cited by 69 · see citing works
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Resolved: Autistic Children Should Have a Trial of Naltrexone
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Resolved: Autistic Children Should Have a Trial of Naltrexone
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Roy, A., Roy, M., Deb, S., Unwin, G., & Roy, A. (2015) · Journal of Intellectual Disability Research · doi:10.1111/jir.12122 · Cited by 82 · see citing works
Immunological Dysfunction in Autism Spectrum Disorder: A Potential Target for Therapy
Marchezan, J., Winkler dos Santos, E. G. A., Deckmann, I., & Riesgo, R. D. S. (2018) · Neuroimmunomodulation · doi:10.1159/000492225 · Cited by 70 · see citing works
Oxytocin under opioid antagonism leads to supralinear enhancement of social attention
Dal Monte, O., Piva, M., Anderson, K. M., Tringides, M., Holmes, A. J., & Chang, S. W. C. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1702725114 · Cited by 55 · see citing works
- Authors
- Williams, P. G., Allard, A., Sears, L., Dalrymple, N., & Bloom, A. S.
- Affiliations
- University of Louisville (US)
- Venue
- Journal of Autism and Developmental Disorders
- Published
- 2001-02
- Volume
- 31
- Issue
- 1
- Pages
- 103-108
- ISSN
- 0162-3257 (ISSN-L)
- 1573-3432
- OpenAlex
- W1563445983
- Cited by
- 19
- References
- 15
- Citations by year
- 2025: 1 · 2024: 1 · 2021: 1 · 2018: 1 · 2017: 2 · 2014: 2
- FWCI
- 0.52
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Journal of Autism and Developmental Disorders (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
- Social Sciences › Psychology › Developmental and Educational Psychology › Behavioral and Psychological Studies
- Keywords
- naltrexone, autism spectrum disorder, children, medication management, opioid antagonists
- MeSH terms
- Attention, Autistic Disorder, Child, Child Behavior Disorders, Child, Preschool, Double-Blind Method, Humans, Male, Naltrexone, Personality Assessment, Social Behavior, Case-Control Studies
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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