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Cited by 210Autism Spectrum Disorder ResearchAttention Deficit Hyperactivity DisorderBehavioral and Psychological Studies

Naltrexone in autistic children: Behavioral symptoms and attentional learning

CAMPBELL, MAGDA, ANDERSON, LOWELL T., SMALL, ARTHUR M., ADAMS, PHILLIP, GONZALEZ, NILDA M., ERNST, MONTIQUE·1993·Journal of the American Academy of Child & Adolescent Psychiatry
DOI 10.1097/00004583-199311000-00024
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Abstract

Objective To assess critically the short-term efficacy and safety of naltrexone in autistic children and its effects on discrimination learning in the laboratory.Method A parallel group design was employed. After a 2-week placebo baseline period, children were randomly assigned either to naltrexone or to placebo for a period of 3 weeks followed by a one-week posttreatment placebo period. Multiple raters and rating scales were employed in a variety of conditions. Forty-one children, all inpatients, ages 2.9 to 7.8 years, completed the study. Naltrexone reduced hyperactivity and had no effect on discrimination learning in the laboratory. There was a suggestion that it had a beneficial effect on decreasing self-injurious behavior. Untoward effects were mild and transient.Conclusion In the present study, naltrexone significantly reduced only hyperactivity, and no serious untoward effects were observed. The effectiveness of naltrexone in the treatment of autism and self-injurious behavior requires additional assessment in a sample of children with moderate to severe self-injurious behavior.

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Crossref · 10.1097/00004583-199311000-00024

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  • Observational studies in patients with autism have shown that administration of an opioid antagonist could decrease self-injurious behavior, stereotypies, hyperactivity, and withdrawal, while increasing verbal production, social communication, proximity seeking, and eye contact.

    “Observational studies in patients with autism have shown that administration of an opioid antagonist could decrease self-injurious behavior, stereotypies, hyperactivity, and withdrawal, although increasing verbal production, social communication, proximity seeking, and eye contact (47–50).”

    From Oxytocin under opioid antagonism leads to supralinear enhancement of social attention (2017) · cites this paper as [48]

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Authors
CAMPBELL, M., ANDERSON, L. T., SMALL, A. M., ADAMS, P., GONZALEZ, N. M., & ERNST, M.
Affiliations
  • NYU Langone Health (US)
  • Cornell University (US)
Corresponding author
CAMPBELL, MAGDA
Venue
Journal of the American Academy of Child & Adolescent Psychiatry
Publisher
Elsevier BV
Published
1993-11
Volume
32
Issue
6
Pages
1283-1291
ISSN
0890-8567 (ISSN-L)
DOI
10.1097/00004583-199311000-00024
OpenAlex
W2046005693
Cited by
210
References
40
Citations by year
2025: 4 · 2024: 1 · 2023: 3 · 2022: 11 · 2021: 5 · 2020: 2 · 2019: 4 · 2018: 3 · 2017: 5 · 2016: 6 · 2015: 7 · 2014: 9 · 2013: 3 · 2012: 11
FWCI
5.00
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Journal of the American Academy of Child & Adolescent Psychiatry (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (5r01mh032212-12, 2t32mh018915-06)
  • National Institute of Mental Health (NIMH MH-18915, NIMH MH-32212)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
  • Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
  • Social Sciences › Psychology › Developmental and Educational Psychology › Behavioral and Psychological Studies
Keywords
naltrexone, autism spectrum disorder, children with autism, hyperactivity, self-harm, discrimination learning, attentional learning, behavioral symptoms, drug efficacy, drug safety, hospitalized children
MeSH terms
Attention, Autistic Disorder, Child, Child, Preschool, Discrimination Learning, Female, Humans, Male, Naltrexone, Psychiatric Status Rating Scales, Severity of Illness Index, Stereotyped Behavior, Weight Loss, Self-Injurious Behavior, Treatment Outcome

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