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Cited by 302Cancer Risks and FactorsPhysical Activity and HealthMetabolism, Diabetes, and Cancer

The DOI matches its Crossref record; 209 of the 211 references it cites were found in a registry or an index.

Physical activity and cancer etiology: associations and mechanisms

McTiernan, Anne, Ulrich, Cornelia, Slate, Shelley, Potter, John·1998·Cancer Causes & Control
DOI 10.1023/a:1008853601471
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Abstract

Objectives This paper reviews the epidemiologic data of associations between physical activity and cancer risk, describes potential mechanisms for a physical activity cancer link, and proposes future directions for research.Methods We reviewed English-language published papers on physical activity and cancer through Medline searches for epidemiologic studies, and through references on individual reports. We reviewed general texts on effects of exercise on human biology and applied the concepts to the biology of cancer in humans to describe potential mechanisms for a physical activity-cancer association.Results Considerable epidemiologic evidence has accrued linking increased physical activity with reduced occurrence of cancers of the breast and colon. The association between physical activity and cancers of other sites is unclear. Potential mechanisms for the association between physical activity and reduced risk for breast and colon cancer are varied: they range from bias due to physical activity's strong correlations with other health factors (e.g., diet, smoking, alcohol use, use of medications) to the metabolic effects resulting from increased physical activity and fitness, such as reduced obesity, hormonal and reproductive effects, mechanical effects, and enhancement of the immune system.Conclusions The elucidation of biologic mechanisms for an association between physical activity and cancer may provide biological support for the association. It will contribute information to determine the type, frequency, and duration of exercise needed to maximize protection. This information will be needed before large-scale community interventions are begun, in order to choose the correct interventions for the desired effect of reduced incidence of the most common cancers.

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Crossref · 10.1023/a:1008853601471

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2 of the 211 references couldn’t be matched to a known paper.

Research works printed but not linked: 6

  1. Durstine JL, King AC, Painter PL, et al. American College Sports Medicine Resource Manual for Guidelines for Exercise Testing and Prescription. 2nd ed. Philadelphia, PA: Lea & Febiger; 1993.
  2. Cerhan J, Chiu B, Wallace R, et al. Systolic blood pressure, physical activity, and risk of breast cancer in elderly women (abstract). Am J Epidemiol 1996; 143: S71.
  3. Carpenter CL, Ross R, Paginini-Hill A, Bernstein L. Lifetime physical activity and breast cancer risk among postmenopausal women (abstract). Am J Epidemiol 1996; 143: S87.
  4. Gram I, Funkhouser E, Tabar L. Physical activity in relation to mammographic patterns. Am J Epidemiol 1996; 143: S71.
  5. Schwartz R, Buchner D. Exercise in the elderly: physiologic and functional effects. In: Hazzard W, ed. Principles of Geriatric Medicine. New York: McGraw-Hill, 1998.
  6. Cauley J, Lucas F, Kuller L, Stone K, Cummings S. Is bone mineral density a biological marker of a woman's cumulative exposure to estrogen? American Epidemiological Society, Rochester, MN; 1997.

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Metadata

Authors
McTiernan, A., Ulrich, C., Slate, S., & Potter, J.
Affiliations
  • Fred Hutch Cancer Center (US)
  • University of Washington (US)
ORCID
Venue
Cancer Causes & Control
Publisher
Springer Science and Business Media LLC
Published
1998-10
Volume
9
Issue
5
Pages
487-509
ISSN
  • 0957-5243 (ISSN-L)
  • 1573-7225
DOI
10.1023/a:1008853601471
OpenAlex
W1577435804
Cited by
302
References
211
Citations by year
2025: 2 · 2024: 4 · 2023: 1 · 2022: 2 · 2021: 2 · 2020: 5 · 2019: 5 · 2018: 3 · 2017: 5 · 2016: 10 · 2015: 4 · 2014: 10 · 2013: 14 · 2012: 15
FWCI
1.78
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Cancer Causes & Control (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Cancer Institute (R01 CA/AG69334, 5 P30 CA15704, P30CA015704)
Topics
  • Health Sciences › Medicine › Oncology › Cancer Risks and Factors
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Physical Activity and Health
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
Keywords
physical activity, cancer risk, breast cancer, colon cancer, biological mechanisms, obesity, endocrine effects, reproductive factors, immune system, cancer prevention, exercise intervention
MeSH terms
Adult, Aged, Aged, 80 and over, Data Collection, Female, Humans, Life Style, Male, Middle Aged, Neoplasms, Prognosis, Cohort Studies, Exercise, Incidence, Survival Rate, Risk Assessment

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