Mitochondrial Uncoupling Proteins in Mammals and Plants

Uncoupling protein-2: a novel gene linked to obesity and hyperinsulinemia

Fleury, C., Neverova, M., Collins, S., Raimbault, S., Champigny, O., Lévi-Meyrueis, C., Bouillaud, F., Seldin, M. F., Surwit, R. S., Ricquier, D., et al. (1997) · Nature Genetics · doi:10.1038/ng0397-269 · Cited by 1,630

Thermogenic mechanisms in brown fat.

Nicholls, D. G., & Locke, R. M. (1984) · Physiological Reviews · doi:10.1152/physrev.1984.64.1.1 · Cited by 1,602

Combining evidence using p-values: application to sequence homology searches.

Bailey, T. L., & Gribskov, M. (1998) · Bioinformatics · doi:10.1093/bioinformatics/14.1.48 · Cited by 1,254

Uncoupling protein‐3: a new member of the mitochondrial carrier family with tissue‐specific expression

Boss, O., Samec, S., Paoloni‐Giacobino, A., Rossier, C., Dulloo, A. G., Seydoux, J., Muzzin, P., & Giacobino, J. (1997) · FEBS Letters · doi:10.1016/s0014-5793(97)00384-0 · Cited by 1,041

The uncoupling protein homologues: UCP1, UCP2, UCP3, StUCP and AtUCP

Ricquier, D., & Bouillaud, F. (2000) · Biochemical Journal · doi:10.1042/bj3450161 · Cited by 811

A role for uncoupling protein‐2 as a regulator of mitochondrial hydrogen peroxide generation

Nègre‐Salvayre, A., Hirtz, C., Carrera, G., Cazenave, R., Troly, M., Salvayre, R., Pénicaud, L., & Casteilla, L. (1997) · The FASEB Journal · doi:10.1096/fasebj.11.10.9271366 · Cited by 773

Uncoupling Protein-3 Is a Mediator of Thermogenesis Regulated by Thyroid Hormone, β3-Adrenergic Agonists, and Leptin

Gong, D., He, Y., Karas, M., & Reitman, M. L. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.39.24129 · Cited by 740

Chromosomal mapping of two genetic loci associated with blood-pressure regulation in hereditary hypertensive rats

Hilbert, P., Lindpaintner, K., Beckmann, J. S., Serikawa, T., Soubrier, F., Dubay, C., Cartwright, P., Gouyon, B., Julier, C., Takahasi, S., et al. (1991) · Nature · doi:10.1038/353521a0 · Cited by 609

Cloning and Characterization of an Uncoupling Protein Homolog: A Potential Molecular Mediator of Human Thermogenesis

Gimeno, R. E., Dembski, M., Weng, X., Deng, N., Shyjan, A. W., Gimeno, C. J., Iris, F., Ellis, S. J., Woolf, E. A., & Tartaglia, L. A. (1997) · Diabetes · doi:10.2337/diab.46.5.900 · Cited by 496

Fatty acid circuit as a physiological mechanism of uncoupling of oxidative phosphorylation

Skulachev, V. P. (1991) · FEBS Letters · doi:10.1016/0014-5793(91)80658-p · Cited by 467

Brown Adipose Tissue: Function and Physiological Significance

CANNON, B., & NEDERGAARD, J. (2004) · Physiological Reviews · doi:10.1152/physrev.00015.2003 · Cited by 6,433

The roles of segmental and tandem gene duplication in the evolution of large gene families in Arabidopsis thaliana

Cannon, S. B., Mitra, A., Baumgarten, A. M., Young, N. D., & May, G. (2004) · BMC Plant Biology · doi:10.1186/1471-2229-4-10 · Cited by 2,415

Thermogenic Mechanisms and Their Hormonal Regulation

Silva, J. E. (2006) · Physiological Reviews · doi:10.1152/physrev.00009.2005 · Cited by 687

The mitochondrial uncoupling-protein homologues

Krauss, S., Zhang, C., & Lowell, B. B. (2005) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1592 · Cited by 670

Mitochondrial uncoupling proteins—What is their physiological role?

Echtay, K. S. (2007) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2007.08.011 · Cited by 349

The ‘Novel’‘Uncoupling’ Proteins UCP2 and UCP3: What Do They Really do? Pros and Cons for Suggested Functions

Nedergaard, J., & Cannon, B. (2003) · Experimental Physiology · doi:10.1113/eph8802502 · Cited by 229

An Arabidopsis Mitochondrial Uncoupling Protein Confers Tolerance to Drought and Salt Stress in Transgenic Tobacco Plants

Begcy, K., Mariano, E. D., Mattiello, L., Nunes-Laitz, A. V., Mazzafera, P., Maia, I. G., & Menossi, M. (2011) · PLoS ONE · doi:10.1371/journal.pone.0023776 · Cited by 221

PLANT UNCOUPLING MITOCHONDRIAL PROTEINS

Vercesi, A. E., Borecký, J., Maia, I. G., Arruda, P., Cuccovia, I. M., & Chaimovich, H. (2006) · Annual Review of Plant Biology · doi:10.1146/annurev.arplant.57.032905.105335 · Cited by 213

Overexpression of uncoupling protein 3 in skeletal muscle protects against fat-induced insulin resistance

Choi, C. S., Fillmore, J. J., Kim, J. K., Liu, Z., Kim, S., Collier, E. F., Kulkarni, A. S., Distefano, A. G., Hwang, Y.-J., Kahn, M., et al. (2007) · Journal of Clinical Investigation · doi:10.1172/jci13579 · Cited by 183

Uncoupling proteins: A role in protection against reactive oxygen species—or not?

Cannon, B., Shabalina, I. G., Kramarova, T. V., Petrovic, N., & Nedergaard, J. (2006) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2006.05.016 · Cited by 182

UCP2, a mitochondrial protein regulated at multiple levels

Donadelli, M., Dando, I., Fiorini, C., & Palmieri, M. (2013) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-013-1407-0 · Cited by 175

Comprehensive characterization and RNA-Seq profiling of the HD-Zip transcription factor family in soybean (Glycine max) during dehydration and salt stress

Belamkar, V., Weeks, N. T., Bharti, A. K., Farmer, A. D., Graham, M. A., & Cannon, S. B. (2014) · BMC Genomics · doi:10.1186/1471-2164-15-950 · Cited by 152

The plant energy-dissipating mitochondrial systems: depicting the genomic structure and the expression profiles of the gene families of uncoupling protein and alternative oxidase in monocots and dicots

Borecký, J., Nogueira, F. T. S., de Oliveira, K. A. P., Maia, I. G., Vercesi, A. E., & Arruda, P. (2006) · Journal of Experimental Botany · doi:10.1093/jxb/erj070 · Cited by 130

Uncoupling protein 1 in fish uncovers an ancient evolutionary history of mammalian nonshivering thermogenesis

Jastroch, M., Wuertz, S., Kloas, W., & Klingenspor, M. (2005) · Physiological Genomics · doi:10.1152/physiolgenomics.00070.2005 · Cited by 128

Comparative analysis of uncoupling protein 4 distribution in various tissues under physiological conditions and during development

Тихоновна, С. А., Rupprecht, A., Sarilova, I. L., Ninnemann, O., Bräuer, A. U., Franke, K., Schumacher, S., Techritz, S., Nitsch, R., Schuelke, M., et al. (2009) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2009.07.018 · Cited by 71

Plant Uncoupling Mitochondrial Protein and Alternative Oxidase: Energy Metabolism and Stress

Borecký, J., & Vercesi, A. E. (2005) · Bioscience Reports · doi:10.1007/s10540-005-2889-2 · Cited by 70

Regulation of Thermogenesis in Plants: The Interaction of Alternative Oxidase and Plant Uncoupling Mitochondrial Protein

Zhu, Y. J., Lu, J., Wang, J., Chen, F., Leng, F., & Li, H. (2010) · Journal of Integrative Plant Biology · doi:10.1111/j.1744-7909.2010.01004.x · Cited by 60

Pig has no uncoupling protein 1

Hou, L., Shi, J., Cao, L., Xu, G., Hu, C. Y., & Wang, C. (2017) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2017.04.118 · Cited by 59

Brown adipose tissue growth and development: significance and nutritional regulation

Satterfield, M. C. (2010) · Frontiers in bioscience · doi:10.2741/3807 · Cited by 46

Respiration, oxidative phosphorylation, and uncoupling protein in Candida albicans

Cavalheiro, R. A., Fortes, F., Borecký, J., Faustinoni, V. C., & Schreiber, A. Z. (2004) · Brazilian Journal of Medical and Biological Research · doi:10.1590/s0100-879x2004001000003 · Cited by 44

Effects of central irisin administration on the uncoupling proteins in rat brain

Erden, Y., Tekin, S., Sandal, S., Etem, E. Ö., Tektemur, A., & Kırbağ, S. (2016) · Neuroscience Letters · doi:10.1016/j.neulet.2016.02.046 · Cited by 42

Genomic structure and expression of uncoupling protein 2 genes in rainbow trout (Oncorhynchus mykiss)

Coulibaly, I., Gahr, S. A., Palti, Y., Yao, J., & Rexroad, C. E. (2006) · BMC Genomics · doi:10.1186/1471-2164-7-203 · Cited by 37

Overexpression of uncoupling protein 4 promotes proliferation and inhibits apoptosis and differentiation of preadipocytes

Zhang, M., Wang, B., Ni, Y., Liu, F., Li, F., Pan, X.-Q., Guo, M., Chen, R., & Guo, X. (2006) · Life Sciences · doi:10.1016/j.lfs.2006.04.012 · Cited by 39

Uncoupling proteins of invertebrates: A review

Słocińska, M., Barylski, J., & Jarmuszkiewicz, W. (2016) · IUBMB Life · doi:10.1002/iub.1535 · Cited by 37

Type-2 Iodothyronine 5′Deiodinase (D2) in Skeletal Muscle of C57Bl/6 Mice. II. Evidence for a Role of D2 in the Hypermetabolism of Thyroid Hormone Receptor α-Deficient Mice

Ramadan, W., Marsili, A., Larsen, P. R., Zavacki, A. M., & Silva, J. E. (2011) · Endocrinology · doi:10.1210/en.2011-0139 · Cited by 37

Uncoupling protein 2 and 3 in marsupials: identification, phylogeny, and gene expression in response to cold and fasting in Antechinus flavipes

Jastroch, M., Withers, K., & Klingenspor, M. (2004) · Physiological Genomics · doi:10.1152/physiolgenomics.00165.2003 · Cited by 35

Regional distribution of manganese superoxide dismutase 2 (Mn SOD2) expression in rodent and primate spiral ganglion cells

Ying, Y. M., & Balaban, C. D. (2009) · Hearing Research · doi:10.1016/j.heares.2009.04.006 · Cited by 31

White, brite, and brown adipocytes: the evolution and function of a heater organ in mammals

Li, Y., Lasar, D., Fromme, T., & Klingenspor, M. (2013) · Canadian Journal of Zoology · doi:10.1139/cjz-2013-0165 · Cited by 29

Molecular evolution of uncoupling proteins and implications for brain function

Gaudry, M. J., & Jastroch, M. (2018) · Neuroscience Letters · doi:10.1016/j.neulet.2018.12.027 · Cited by 28

Identification and characterization of uncoupling protein 4 in fat body and muscle mitochondria from the cockroach Gromphadorhina cocquereliana

Słocińska, M., Antos-Krzemińska, N., Rosiński, G., & Jarmuszkiewicz, W. (2011) · Journal of Bioenergetics and Biomembranes · doi:10.1007/s10863-011-9385-0 · Cited by 28

Reptilian uncoupling protein: functionality and expression in sub-zero temperatures

Rey, B., Sibille, B., Romestaing, C., Belouze, M., Letexier, D., Servais, S., Barré, H., Duchamp, C., & Voituron, Y. (2008) · Journal of Experimental Biology · doi:10.1242/jeb.012328 · Cited by 25

Identification of uncoupling protein 4 from the blood-sucking insect Rhodnius prolixus and its possible role on protection against oxidative stress

Alves‐Bezerra, M., Cosentino‐Gomes, D., Vieira, L. P., Rocco-Machado, N., Gondim, K. C., & Meyer‐Fernandes, J. R. (2014) · Insect Biochemistry and Molecular Biology · doi:10.1016/j.ibmb.2014.03.011 · Cited by 22

Role of mitochondrial uncoupling protein 4 in rat inner ear

Тихоновна, С. А., Rupprecht, A., Fuchs, J., Gross, J., & Pohl, E. E. (2011) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2011.03.002 · Cited by 19

Genomic Structure and Regulation of Mitochondrial Uncoupling Protein Genes in Mammals and Plants

Nogueira, F. T. S., Borecký, J., Vercesi, A. E., & Arruda, P. (2005) · Bioscience Reports · doi:10.1007/s10540-005-2886-5 · Cited by 18

A thermogenic secondary sexual character in male sea lamprey

Chung‐Davidson, Y., Priess, M. C., Yeh, C., Brant, C. O., Johnson, N. S., Li, K., Nanlohy, K. G., Bryan, M. B., Brown, C. T., Choi, J., et al. (2013) · Journal of Experimental Biology · doi:10.1242/jeb.085746 · Cited by 17

The distribution of electron transport between the main cytochrome and alternative pathways in plant mitochondria during short-term cold stress and cold hardening

Grabelnych, O. I., Sumina, O. N., Funderat, S. P., Побежимова, Т. П., Войников, В. К., & Колесниченко, А. В. (2004) · Journal of Thermal Biology · doi:10.1016/j.jtherbio.2004.02.002 · Cited by 16

Understanding glucose uptake during methionine deprivation in incubated rainbow trout (Oncorhynchus mykiss) hepatocytes using a non-radioactive method

Craig, P. M., Massarsky, A., & Moon, T. W. (2013) · Comparative Biochemistry and Physiology Part B Biochemistry and Molecular Biology · doi:10.1016/j.cbpb.2013.06.005 · Cited by 15

Cloning, ontogenesis, and localization of an atypical uncoupling protein 4 inXenopus laevis

Keller, P. A., Lehr, L., Giacobino, J., Charnay, Y., Assimacopoulos‐Jeannet, F., & Giovannini, N. (2005) · Physiological Genomics · doi:10.1152/physiolgenomics.00012.2005 · Cited by 15

Transport Pathways—Proton Motive Force Interrelationship in Durum Wheat Mitochondria

Trono, D., Laus, M. N., Soccio, M., & Pastore, D. (2014) · International Journal of Molecular Sciences · doi:10.3390/ijms15058186 · Cited by 14

Brown Adipose Tissue: Development and Function

Nedergaard, J., & Cannon, B. (2011) · Elsevier eBooks · doi:10.1016/b978-1-4160-3479-7.10043-6 · Cited by 13

Functional analysis of skunk cabbage SfUCPB, a unique uncoupling protein lacking the fifth transmembrane domain, in yeast cells

Ito, K., Matsukawa, K., & Kato, Y. S. (2006) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2006.08.058 · Cited by 13

A New Strategy for Targeting UCP2 to Modulate Glycolytic Reprogramming as a Treatment for Sepsis A New Strategy for Targeting UCP2

Li, N., Deng, J., Zhang, J., Yu, F., Ye, F., Hao, L., Li, S., & Hu, X. (2024) · Inflammation · doi:10.1007/s10753-024-01998-4 · Cited by 9

Mitochondrial uncoupling proteins regulate angiotensin-converting enzyme expression: crosstalk between cellular and endocrine metabolic regulators suggested by RNA interference and genetic studies

Dhamrait, S. S., Maubaret, C. G., Pedersen‐Bjergaard, U., Brull, D. J., Gohlke, P., Payne, J. R., WORLD, M. J., Thorsteinsson, B., Humphries, S. E., & Montgomery, H. (2015) · Inside the Cell · doi:10.1002/icl3.1019 · Cited by 8

Mitochondrial uncoupling proteins regulate angiotensin‐converting enzyme expression: crosstalk between cellular and endocrine metabolic regulators suggested by RNA interference and genetic studies

Dhamrait, S. S., Maubaret, C. G., Pedersen‐Bjergaard, U., Brull, D. J., Gohlke, P., Payne, J. R., WORLD, M. J., Thorsteinsson, B., Humphries, S. E., & Montgomery, H. (2016) · BioEssays · doi:10.1002/bies.201670909 · Cited by 8

Mitochondria and the regulation of free radical damage in the eye

Barnstable, C. J. (2009) · Journal of ocular biology, diseases, and informatics · doi:10.1007/s12177-009-9036-4 · Cited by 7

The roles of orexins on sleep/wakefulness, energy homeostasis and intestinal secretion

Mäkelä, K. A. (2010) · Cited by 7

A Risky Job: In Search of Noncanonical Pathways

Skulachev, V. P. (2003) · Comprehensive biochemistry · doi:10.1016/s0069-8032(03)42011-1 · Cited by 5

Thermoregulation in the appendix of the Sauromatum guttatum (Schott) inflorescence

Skubatz, H. (2014) · Botanical studies · doi:10.1186/s40529-014-0068-0 · Cited by 3

Mutational analysis of Arabidopsis thaliana plant uncoupling mitochondrial protein

Fávaro, R. D., Borecký, J., Colombi, D., Vercesi, A. E., & Maia, I. G. (2007) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2007.09.005 · Cited by 3

Characterization of cold responsive uncoupling protein1 (UCP1) gene from Brassica juncea L. (Czern. and Coss.)

Lakhanpal, N., Verma, D., Kaur, R., & Singh, K. (2017) · Journal of Plant Biochemistry and Biotechnology · doi:10.1007/s13562-017-0421-y · Cited by 3

Brown Adipose Tissue: Development and Function

Nedergaard, J., & Cannon, B. (2004) · Elsevier eBooks · doi:10.1016/b978-0-7216-9654-6.50044-8 · Cited by 3

Genómica nutricional y obesidad

Reyes, J. G. G., Meléndez, G., Rivera, A. Z., & Zúñiga, A. S. (2006) · Revista de Endocrinología y Nutrición · Cited by 2

Conformation and Ion Transport of Neuronal Uncoupling Proteins

Hoang, T. A., Smith, M. D., & Jelokhani‐Niaraki, M. (2011) · Biophysical Journal · doi:10.1016/j.bpj.2010.12.2148 · Cited by 1

Conformation and ion transport of neuronal uncoupling proteins: UCP2, UCP4, and UCP5

Hoang, T. A. (2011) · Scholars Commons (Wilfrid Laurier University) · Cited by 1

Untersuchung von Muskelgewebe amyotorpher lateraler Sklerose : Etiologie, Diagnose und therapeutische Aspekte

Scala, F. D. (2006) · edoc (University of Basel) · doi:10.5451/unibas-004071740

Análise funcional das proteínas desacopladas mitocondriais de plantas utilizando RNA-seq e mutantes de inserção

Nunes-Laitz, A. V. (2014) · Americanae (AECID Library)

ANÁLISE BIOQUÍMICA, ESTUDOS DA RELAÇÃO ESTRUTURA-FUNÇÃO E DE EXPRESSÃO DA PROTEÍNA DESACOPLADORA MITOCONDRIAL DE PLANTAS

Fávaro, R. D. (2008) · Americanae (AECID Library)

Modulação da atividade mitocondrial pela S-nitrosoglutationa redutase em resposta ao estresse nutricional em suspensões celulares de Arabidopsis thaliana

Lima, L. F. (2011) · doi:10.47749/t/unicamp.2011.807010

Efeito do estresse pelo frio sobre células embriogênicas de Araucaria angustifolia em cultura: disfunção mitocondrial e estresse oxidativo

Valente, C. (2012) · LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas)

Efecto agudo de la ingesta de cafeína en personas con baja o alta activación del tejido adiposo pardo estimado por termografía infrarroja = Acute effect of caffeine intake on people with low or high activation of brown adipose tissue estimated by infrared thermography

Pérez, D. V. (2020) · doi:10.20868/upm.thesis.66181

Uncoupling proteins : regulation by IGF-1 and neuroprotection during hyperglycemia in vitro.

Gustafsson, H. (2004) · KTH Publication Database DiVA (KTH Royal Institute of Technology)

Plant respiration. Functions and regulation of respiratory pathways

Garmash, E. V. (2026) · doi:10.19110/978-5-89606-709-2

Genomic Structure and Regulation of Mitochondrial Uncoupling Protein Genes in Mammals and Plants

Nogueira, F. T. S., Borecký, J., Vercesi, A. E., & Arruda, P. (2005) · Bioscience Reports · doi:10.1007/s10540-005-2886-5 · Cited by 18

Uncoupling proteins (UCP) in unicellular eukaryotes: True UCPs or UCP1‐like acting proteins?

Luévano‐Martínez, L. A. (2012) · FEBS Letters · doi:10.1016/j.febslet.2012.03.009 · Cited by 8

The plant uncoupling protein homologues: a new family of energy-dissipating proteins in plant mitochondria

Hourton-Cabassa, C., Rita Matos, A., Zachowski, A., & Moreau, F. (2004) · Plant Physiology and Biochemistry · doi:10.1016/j.plaphy.2004.01.007 · Cited by 65

The uncoupling protein homologues: UCP1, UCP2, UCP3, StUCP and AtUCP

Ricquier, D., & Bouillaud, F. (2000) · Biochemical Journal · doi:10.1042/bj3450161 · Cited by 811

The Biology of Mitochondrial Uncoupling Proteins

Rousset, S., Alves‐Guerra, M., Mozo, J., Miroux, B., Cassard, A., Bouillaud, F., & Ricquier, D. (2004) · Diabetes · doi:10.2337/diabetes.53.2007.s130 · Cited by 560