Cited by 63Mitochondrial Function and PathologyATP Synthase and ATPases ResearchAdipose Tissue and Metabolism

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Mitochondrial Uncoupling Proteins in Mammals and Plants

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Borecký, Jirí, Maia, Ivan G., Arruda, Paulo·2001·Bioscience Reports

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Abstract

Uncoupling proteins (UCPs) belong to a distinct cluster of the mitochondrial anion carrier family. Up to five different uncoupling protein types were found in mitochondria of mammals and plants, and recently in fishes, fungi and protozoa. They exhibit a significantly conserved structure with several motifs specific to either the whole cluster or protein type. Uncoupling proteins, as well as the whole mitochondrial anion carrier gene family, probably emerged in evolution before the separation of animal, fungi, and plant kingdoms and originate from an anion/nucleotide or anion/anion transporter ancestor. Mammalian UCP1, UCP2, UCP3, and plant uncoupling proteins pUCP1 and pUCP2 are similar and seem to form one subgroup, whereas UCP4 and BMCP1 belong to a different group. Molecular, biochemical, and phylogenic data suggest that UCP2 could be considered as an UCP-prototype. UCP1 plays its biological role mainly in the non-shivering thermogenesis while the role of the other types is unknown. However, hypotheses have suggested that they are involved in the general balance of basic energy expenditure, protection from reactive oxygen species, and, in plants, in fruit ripening and seed ontogeny.

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Authors: Borecký, J., Maia, I. G., & Arruda, P.
Affiliations: Department of Membrane Transport Biophysics, Institute of Physiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic
Universidade Estadual de Campinas (UNICAMP) (BR)
ORCID: Maia, Ivan G.
Arruda, Paulo
Venue: Bioscience Reports
Publisher: Portland Press Ltd.
Published: 2001-04-01
Volume: 21
Issue: 2
Pages: 201-212
ISSN: 0144-8463 (ISSN-L)
1573-4935
DOI: 10.1023/a:1013604526175
OpenAlex: W1848253824
Cited by: 63
References: 57
Citations by year: 2026: 1 · 2024: 1 · 2020: 1 · 2018: 1 · 2017: 2 · 2016: 4 · 2015: 1 · 2014: 5 · 2013: 4 · 2012: 1
FWCI: 1.04
Type: journal article
Language: en
Open access: green
www.repositorio.unicamp.br
Licence: other-oa
Locations: Bioscience Reports (publishedVersion)
PubMed (publishedVersion)
LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (publishedVersion, other-oa)
Americanae (AECID Library) (submittedVersion, other-oa)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › ATP Synthase and ATPases Research
Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
Keywords: uncoupling proteins, UCP1, UCP2, UCP3, UCP4, protein evolution, phylogenetic analysis, non-shivering thermogenesis, fruit ripening, seed ontogeny, energy expenditure, mammals, plants
MeSH terms: Uncoupling Protein 1, Amino Acid Sequence, Animals, Carrier Proteins, Ion Channels, Membrane Proteins, Mitochondria, Molecular Sequence Data, Phylogeny, Plant Proteins, Protein Structure, Tertiary, Plant Physiological Phenomena, Thermogenesis, Mitochondrial Proteins

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Mitochondrial Uncoupling Proteins in Mammals and Plants

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