Fatty acid circuit as a physiological mechanism of uncoupling of oxidative phosphorylation
Open accessAbstract
Free fatty acids, natural uncouplers of oxidative phosphorylation, are shown to differ from artificial ones in that they fail to increase conductance of phospholipid bilayers which are permeable for the protonated form of fatty acids but impermeable for their anionic form. Recent studies have revealed that uncoupling by fatty acids in mitochondria is mediated by the ATP/ADP antiporter and, in brown fat, by thermogenin which is structurally very similar to the antiporter. It is suggested that both the ATP/ADP antiporter and thermogenin facilitate translocation of the fatty anions through the mitochondrial membrane.
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An increase in UCP-1 protein expression and activity accounted for the promoted thermogenic capacity in PUFA-enriched HFD mice.
“An increase in UCP-1 protein expression and activity (acting as an efficient monocarboxylic FA anion flippase and regulated by GDP [283]) accounted for the promoted thermogenic capacity [282].”
From Mitochondrial Uncoupling: A Key Controller of Biological Processes in Physiology and Diseases (2019) · cites this paper as [283]
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“During dietary insufficiency, the brain (Knobloch et al., 2013), liver (Dorn et al., 2010) and adipose tissues (Mayas et al., 2010) can synthesize fatty acids (Skulachev 1991; Menendez and Lupu 2007; Knobloch et al., 2013).”
Background
- Authors
- Skulachev, V. P.
- Affiliations
- Lomonosov Moscow State University (RU)
- Corresponding author
- Skulachev, Vladimir P.
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 1991-12-09
- Volume
- 294
- Issue
- 3
- Pages
- 158-162
- ISSN
- 0014-5793 (ISSN-L)
- 1873-3468
- OpenAlex
- W2031165402
- Cited by
- 467
- References
- 33
- Citations by year
- 2026: 1 · 2025: 10 · 2024: 5 · 2023: 7 · 2022: 10 · 2021: 14 · 2020: 11 · 2019: 13 · 2018: 19 · 2017: 10 · 2016: 16 · 2015: 12 · 2014: 15 · 2013: 11 · 2012: 13
- FWCI
- 0.98
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- FEBS Letters (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › ATP Synthase and ATPases Research
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Keywords
- free fatty acids, mitochondrial uncoupling, thermogenin, brown adipose tissue, mitochondrial membrane, uncouplers
- MeSH terms
- Uncoupling Protein 1, Mitochondrial ADP, ATP Translocases, Animals, Adipose Tissue, Brown, Carrier Proteins, Fatty Acids, Intracellular Membranes, Ion Channels, Membrane Proteins, Mitochondria, Models, Biological, Oxidative Phosphorylation, Uncoupling Agents, Mitochondrial Proteins
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