Lifestyle and nutritional determinants of bioavailable androgens and related hormones in British men
Abstract
Objective To investigate the lifestyle and nutritional determinants of serum bioavailable androgens and their related hormones in men. Methods This study is based on a sample of 696 men with a wide range of nutrient intakes, whose diet and lifestyle characteristics were assessed with a questionnaire and serum sex hormones measured using immunoassays. Results Men aged 70 years or older had 12% lower testosterone and 40% lower free-testosterone (FT) and androstanediol glucuronide (A-diol-g) concentrations than men who were 20-29 years of age. Conversely, sex hormone-binding globulin (SHBG) and luteinizing hormone (LH) concentrations were 90% and 49% higher in the oldest age group compared with the lowest, respectively. Men who had a body mass index (BMI) of 30+ kg/m2 had 30% lower testosterone, 45% lower SHBG, 22% lower LH and 5% lower FT concentrations compared with men with a BMI of Conclusions Age is the strongest determinant of serum bioavailable androgens. BMI and some lifestyle and dietary factors influence SHBG and testosterone concentrations, but have no strong association with FT, suggesting that homeostasis is effective. A-diol-g shows broadly similar associations to FT, with the exception of the effect of BMI and alcohol.
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Age and race are well-established, non-modifiable predictors of sex steroid hormone concentrations in men.
“Age [13, 14] and race [13–15] are well-established, but non-modifiable, predictors of sex steroid hormone concentrations in men.”
From Association of cigarette smoking, alcohol consumption, and physical activity with sex steroid hormone levels in US men (2009) · cites this paper as [15]
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- Authors
- Allen, N. E., Appleby, P. N., Davey, G. K., & Key, T. J.
- Affiliations
- Cancer Research UK (GB)
- Corresponding author
- Allen, Naomi E.
- Venue
- Cancer Causes & Control
- Published
- 2002-05
- Volume
- 13
- Issue
- 4
- Pages
- 353-363
- ISSN
- 0957-5243 (ISSN-L)
- 1573-7225
- OpenAlex
- W1491680646
- Cited by
- 153
- References
- 7
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 4 · 2023: 7 · 2022: 8 · 2021: 8 · 2020: 3 · 2019: 3 · 2018: 5 · 2017: 10 · 2016: 8 · 2015: 3 · 2014: 8 · 2013: 8 · 2012: 10
- FWCI
- 2.52
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Cancer Causes & Control (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
- Health Sciences › Medicine › Reproductive Medicine › Sperm and Testicular Function
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Keywords
- testosterone, free testosterone, sex hormone-binding globulin, luteinizing hormone, androstanediol glucuronide, aging, body mass index, waist circumference, smoking, physical activity, alcohol consumption, saturated fat intake, dietary factors, men's health, British men, obesity
- MeSH terms
- Adult, Age Factors, Biological Availability, Diet, England, Humans, Luteinizing Hormone, Life Style, Male, Middle Aged, Nutritional Status, Smoking, Testosterone, Body Mass Index
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