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Cited by 168Hormonal and reproductive studiesSperm and Testicular FunctionHypothalamic control of reproductive hormones

Androgens and obesity

Allan, Carolyn A, McLachlan, Robert I·2010·Current Opinion in Endocrinology, Diabetes & Obesity
DOI 10.1097/med.0b013e3283398ee2
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Abstract

PURPOSE OF REVIEW: As testosterone levels are frequently reduced in obesity, an understanding of the relationship between serum testosterone and adiposity is necessary in the clinical evaluation of these men, in particular when considering testosterone therapy. RECENT FINDINGS: Population and interventional data suggest a bi-directional relationship exists between testosterone and obesity in men, with lower total testosterone and sex hormone binding globulin (SHBG) (and to a lesser extent free testosterone) levels than their nonobese peers; obesity having an impact at least as important as ageing. Abnormalities in the hypothalamo-pituitary-testicular axis are seen with increasing obesity. Weight loss in massive obesity increases testosterone levels but its role in mild-moderate obesity is unclear. Testosterone supplementation reduces total body fat in hypogonadal and ageing men although the effects on regional fat distribution are less well described. SUMMARY: Favourable changes in total body fat and regional fat distribution suggest a potential role for testosterone in obesity. However, lifestyle advice to achieve sustained weight loss should be the mainstay of management. Obese men with confirmed androgen deficiency can be offered treatment, whereas in those with low-normal testosterone levels more research is needed.

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Crossref · 10.1097/med.0b013e3283398ee2

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86 of 86 references verified0 citation errors · 0 not checkable

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  • Reductions in testosterone levels correlate with the severity of obesity and men with a BMI >35-40 kg/m2 have >50% reduction in total and free testosterone levels compared to lean men.

    “Reductions in testosterone levels correlate with the severity of obesity and men with a BMI >35–40 kg m−2 have >50% reduction in total and free testosterone levels compared to lean men.15”

    From Lowered testosterone in male obesity: Mechanisms, morbidity and management (2014) · cites this paper as [15]

  • Multiple groups have observed a significant negative association between obesity and testosterone levels.

    “A significant negative association has also been observed between obesity and T levels by multiple groups,72-74 emphasizing the metabolic importance of maintaining T production with age.”

    From Hormonal and Metabolic Changes of Aging and the Influence of Lifestyle Modifications (2021) · cites this paper as [74]

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Authors
Allan, C. A., & McLachlan, R. I.
Affiliations
Monash Medical Centre (AU)
Corresponding author
McLachlan, Robert I
ORCID
Venue
Current Opinion in Endocrinology, Diabetes & Obesity
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2010-06
Volume
17
Issue
3
Pages
224-232
ISSN
1752-296X (ISSN-L)
DOI
10.1097/med.0b013e3283398ee2
OpenAlex
W2005638302
Cited by
168
References
86
Citations by year
2026: 6 · 2025: 14 · 2024: 8 · 2023: 4 · 2022: 6 · 2021: 8 · 2020: 14 · 2019: 9 · 2018: 10 · 2017: 13 · 2016: 12 · 2015: 17 · 2014: 12 · 2013: 8 · 2012: 10
FWCI
1.58
Type
journal article
Language
en
Open access
closed
Locations
  • Current Opinion in Endocrinology Diabetes and Obesity (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
  • Health Sciences › Medicine › Reproductive Medicine › Sperm and Testicular Function
  • Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
Keywords
androgens, testosterone, obesity, sex hormone-binding globulin, free testosterone, hypogonadism, testosterone replacement therapy, hypothalamic-pituitary-testicular axis, weight loss, regional fat distribution, older men, androgen deficiency
MeSH terms
Adipose Tissue, Aging, Androgens, Body Composition, Humans, Male, Obesity, Sex Hormone-Binding Globulin, Testosterone

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