CoChat
Sign Up
Cited by 183Inflammatory Bowel DiseaseIron Metabolism and DisordersInflammatory mediators and NSAID effects

The DOI matches its Crossref record; 36 of the 37 references it cites were found in a registry or an index.

Dietary Iron Supplementation Enhances DSS-Induced Colitis and Associated Colorectal Carcinoma Development in Mice

Seril, Darren N., Liao, Jie, Ho, Kwok-Lam K., Warsi, Asim, Yang, Chung S., Yang, Guang-Yu·2002·Digestive Diseases and Sciences
DOI 10.1023/a:1015362228659
Open this paper in CoChat — free account

Abstract

Chronic ulcerative colitis (UC) patients frequently require iron supplementation to remedy anemia due to blood loss. However, the effect of iron supplementation on UC-associated carcinogenesis is unknown. In this study, the effect of an iron-enriched diet on dextran sulfate sodium-induced acute and chronic colitis in mice was assessed. In a short-term study, mice administered 1% DSS in the drinking fluid and an AIN76A diet containing increasing levels of iron exhibited dose-dependent increases in the severity of acute UC as compared to mice fed a control diet. A marked increase in iron deposition on the epithelial surface of the colon and in the inflamed areas and immunostaining for iNOS and nitrotyrosine were observed in the animals supplemented with diets containing different levels of iron. In a long-term carcinogenesis experiment, a twofold iron-enriched diet significantly increased colorectal tumor incidence (14/16, 88%) as compared with animals fed the control diet (3/16, 19%; P < 0.001). The present findings have implications for the management of human UC and suggest that dietary iron can enhance UC and its associated carcinogenesis by augmenting oxidative and nitrosative stress.

Overview

Integrity signals

Registry

Crossref · 10.1023/a:1015362228659

Cites

36 of 36 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Flagged first, then by citations

1 of the 37 references couldn’t be matched to a known paper.

Research works printed but not linked: 1

  1. Meeting Report: Molecular mechanism for inflammationpromoted pathogenesis of cancer-the sixteenth international symposium of the Sapporo cancer seminar. Cancer Res 57:3620–3623, 1997

Cited by

Sorted by citations

See all 183

Related

See all

Metadata

Authors
Seril, D. N., Liao, J., Ho, K.-L. K., Warsi, A., Yang, C. S., & Yang, G.-Y.
Affiliations
Rutgers, The State University of New Jersey (US)
ORCID
Venue
Digestive Diseases and Sciences
Publisher
Springer Science and Business Media LLC
Published
2002-06
Volume
47
Issue
6
Pages
1266-1278
ISSN
  • 0163-2116 (ISSN-L)
  • 1573-2568
DOI
10.1023/a:1015362228659
OpenAlex
W1591222484
Cited by
183
References
37
Citations by year
2026: 2 · 2025: 4 · 2024: 6 · 2023: 4 · 2022: 9 · 2021: 11 · 2020: 10 · 2019: 9 · 2018: 6 · 2017: 7 · 2016: 7 · 2015: 4 · 2014: 14 · 2013: 11 · 2012: 9
FWCI
4.43
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Digestive Diseases and Sciences (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institute of Environmental Health Sciences (ES0052)
Topics
  • Health Sciences › Medicine › Gastroenterology › Inflammatory Bowel Disease
  • Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
  • Health Sciences › Medicine › Pharmacology (medical) › Inflammatory mediators and NSAID effects
Keywords
dietary iron supplementation, ulcerative colitis, DSS-induced colitis, colorectal carcinogenesis, nitrosative stress, oxidative stress, inducible nitric oxide synthase, nitrotyrosine, AIN-76A diet
MeSH terms
Animals, Colitis, Ulcerative, Colon, Disease Models, Animal, Dose-Response Relationship, Drug, Female, Mice, Inbred C57BL, Colorectal Neoplasms, Dextran Sulfate, Oxidative Stress, Disease Progression, Iron, Dietary, Dietary Supplements, Mice

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review