Cited by 682Nitric Oxide and Endothelin EffectsRedox biology and oxidative stressCancer and biochemical research

The multifaceted roles of nitric oxide in cancer

Wink, D.·1998·Carcinogenesis

Abstract

The roles of nitric oxide (NO) in numerous disease states have generated considerable discussion over the past several years. NO has been labeled as the causative agent in different pathophysiological mechanisms, yet appears to protect against various chemical species such as those generated under oxidative stress. Similarly, NO appears to exert a dichotomy of effects within the multistage model of cancer. Chronic inflammation can lead to the production of chemical intermediates, among them NO, which in turn can mediate damage to DNA. Yet, NO also appears to be critical for the tumoricidal activity of the immune system. Furthermore, NO can also have a multitude of effects on other aspects of tumor biology, including angiogenesis and metastasis. This report will discuss how the chemistry of NO may impact the initiation and progression stages of cancer.

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Crossref · 10.1093/carcin/19.5.711

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155 of 155 references verified0 citation errors · 0 not checkable

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  • Depending on the sites and amounts of NO generation, NO might represent a double-edged sword in that it confers both protective and deleterious effects on cancer development.

    “Depending on the sites and amounts of NO generation, NO might represent a double-edged sword in the sense that it confers both protective and deleterious effects on cancer development [150,151].”

    From NO-Rich Diet for Lifestyle-Related Diseases (2015) · cites this paper as [150]

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Authors
Wink, D.
Affiliations
National Institutes of Health (US)
Corresponding author
Wink, D.
Venue
Carcinogenesis
Published
1998-05-01
Volume
19
Issue
5
Pages
711-721
ISSN
  • 0143-3334 (ISSN-L)
  • 1460-2180
OpenAlex
W2135783367
Cited by
682
References
155
Citations by year
2026: 2 · 2025: 5 · 2024: 10 · 2023: 15 · 2022: 21 · 2021: 16 · 2020: 22 · 2019: 25 · 2018: 28 · 2017: 28 · 2016: 13 · 2015: 22 · 2014: 25 · 2013: 28 · 2012: 27
FWCI
5.63
Type
journal article
Language
en
Open access
closed
Locations
  • Carcinogenesis (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cancer and biochemical research
Keywords
nitric oxide, cancer, oxidative stress, chronic inflammation, DNA damage, antitumor immunity, angiogenesis, metastasis, tumor initiation, tumor progression
MeSH terms
Animals, DNA Damage, Humans, Neoplasms, Nitric Oxide, Oxidative Stress

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