The multifaceted roles of nitric oxide in cancer
Abstract
The roles of nitric oxide (NO) in numerous disease states have generated considerable discussion over the past several years. NO has been labeled as the causative agent in different pathophysiological mechanisms, yet appears to protect against various chemical species such as those generated under oxidative stress. Similarly, NO appears to exert a dichotomy of effects within the multistage model of cancer. Chronic inflammation can lead to the production of chemical intermediates, among them NO, which in turn can mediate damage to DNA. Yet, NO also appears to be critical for the tumoricidal activity of the immune system. Furthermore, NO can also have a multitude of effects on other aspects of tumor biology, including angiogenesis and metastasis. This report will discuss how the chemistry of NO may impact the initiation and progression stages of cancer.
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Depending on the sites and amounts of NO generation, NO might represent a double-edged sword in that it confers both protective and deleterious effects on cancer development.
“Depending on the sites and amounts of NO generation, NO might represent a double-edged sword in the sense that it confers both protective and deleterious effects on cancer development [150,151].”
From NO-Rich Diet for Lifestyle-Related Diseases (2015) · cites this paper as [150]
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Nitric oxide release: Part II. Therapeutic applications
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Self-citationThe biphasic nature of nitric oxide responses in tumor biology
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“Together, the integration of these effects may define a powerful therapeutic target [235,236].”
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NO-Rich Diet for Lifestyle-Related Diseases
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Inhibition of poly(ADP-ribose) polymerase (PARP) by nitric oxide and reactive nitrogen oxide species
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- Authors
- Wink, D.
- Affiliations
- National Institutes of Health (US)
- Corresponding author
- Wink, D.
- ORCID
- Wink, D.
- Venue
- Carcinogenesis
- Publisher
- Oxford University Press (OUP)
- Published
- 1998-05-01
- Volume
- 19
- Issue
- 5
- Pages
- 711-721
- ISSN
- 0143-3334 (ISSN-L)
- 1460-2180
- OpenAlex
- W2135783367
- Cited by
- 682
- References
- 155
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 10 · 2023: 15 · 2022: 21 · 2021: 16 · 2020: 22 · 2019: 25 · 2018: 28 · 2017: 28 · 2016: 13 · 2015: 22 · 2014: 25 · 2013: 28 · 2012: 27
- FWCI
- 5.63
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Carcinogenesis (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cancer and biochemical research
- Keywords
- nitric oxide, cancer, oxidative stress, chronic inflammation, DNA damage, antitumor immunity, angiogenesis, metastasis, tumor initiation, tumor progression
- MeSH terms
- Animals, DNA Damage, Humans, Neoplasms, Nitric Oxide, Oxidative Stress
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