Cited by 183Inflammatory Bowel DiseaseIron Metabolism and DisordersInflammatory mediators and NSAID effects

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Dietary Iron Supplementation Enhances DSS-Induced Colitis and Associated Colorectal Carcinoma Development in Mice

Seril, Darren N., Liao, Jie, Ho, Kwok-Lam K., Warsi, Asim, Yang, Chung S., Yang, Guang-Yu·2002·Digestive Diseases and Sciences

DOI 10.1023/a:1015362228659

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Abstract

Chronic ulcerative colitis (UC) patients frequently require iron supplementation to remedy anemia due to blood loss. However, the effect of iron supplementation on UC-associated carcinogenesis is unknown. In this study, the effect of an iron-enriched diet on dextran sulfate sodium-induced acute and chronic colitis in mice was assessed. In a short-term study, mice administered 1% DSS in the drinking fluid and an AIN76A diet containing increasing levels of iron exhibited dose-dependent increases in the severity of acute UC as compared to mice fed a control diet. A marked increase in iron deposition on the epithelial surface of the colon and in the inflamed areas and immunostaining for iNOS and nitrotyrosine were observed in the animals supplemented with diets containing different levels of iron. In a long-term carcinogenesis experiment, a twofold iron-enriched diet significantly increased colorectal tumor incidence (14/16, 88%) as compared with animals fed the control diet (3/16, 19%; P < 0.001). The present findings have implications for the management of human UC and suggest that dietary iron can enhance UC and its associated carcinogenesis by augmenting oxidative and nitrosative stress.

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A novel method in the induction of reliable experimental acute and chronic ulcerative colitis in mice
Okayasu, I., Hatakeyama, S., Yamada, M., Ohkusa, T., Inagaki, Y., & NAKAYA, R. (1990) · Gastroenterology · doi:10.1016/0016-5085(90)90290-h · Cited by 2,408
Inflammatory bowel disease: Etiology and pathogenesis
Fiocchi, C. (1998) · Gastroenterology · doi:10.1016/s0016-5085(98)70381-6 · Cited by 2,059
Dysplasia in inflammatory bowel disease: Standardized classification with provisional clinical applications
Riddell, R. H., Goldman, H., Ransohoff, D. F., Appelman, H. D., Fenoglio, C. M., Haggitt, R. C., hren, C., Correa, P., Hamilton, S. R., Morson, B. C., et al. (1983) · Human Pathology · doi:10.1016/s0046-8177(83)80175-0 · Cited by 1,857
Ulcerative Colitis and Colorectal Cancer
Ekbom, A., Helmick, C. G., Zack, M. M., & Adami, H. (1990) · New England Journal of Medicine · doi:10.1056/nejm199011013231802 · Cited by 1,794
The multifaceted roles of nitric oxide in cancer
Wink, D. (1998) · Carcinogenesis · doi:10.1093/carcin/19.5.711 · Cited by 682
Iron Homeostasis, Oxidative Stress, and DNA Damage
Meneghini, R. (1997) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(97)00016-6 · Cited by 578
Evaluation of cyclooxygenase-2 inhibitor for potential chemopreventive properties in colon carcinogenesis.
Reddy, B. S., Rao, C. V., & Seibert, K. (1996) · PubMed · Cited by 421
Oxidative damage and defense
Jacob, R., & Burri, B. (1996) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/63.6.985 · Cited by 408
Differential susceptibility of inbred mouse strains to dextran sulfate sodium-induced colitis
Mähler, M., Bristol, I. J., Leiter, E. H., Workman, A. E., Birkenmeier, E. H., Elson, C. O., & Sundberg, J. P. (1998) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1998.274.3.g544 · Cited by 398
Role of oxidative DNA damage in cancer initiation and promotion.
Poulsen, H. E., Priemé, H., & Loft, S. H. (1998) · PubMed · Cited by 339

Show all 37 references

Research works printed but not linked: 1

Meeting Report: Molecular mechanism for inflammationpromoted pathogenesis of cancer-the sixteenth international symposium of the Sapporo cancer seminar. Cancer Res 57:3620–3623, 1997

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Wang, X., Quan, J., Xiu, C., Wang, J., & Zhang, J. (2023) · Chinese Medicine · doi:10.1186/s13020-023-00819-4 · Cited by 52
Preventive Therapy of Experimental Colitis with Selected iron Chelators and Anti-oxidants.
Minaiyan, M., Mostaghel, E. A., & Mahzouni, P. (2012) · Europe PMC (PubMed Central) · Cited by 52
Iron and health
Calder, P. C. (2010) · ePrints Soton (University of Southampton) · Cited by 49
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Rizvi, S. H., & Schoen, R. E. (2011) · The American Journal of Gastroenterology · doi:10.1038/ajg.2011.232 · Cited by 49
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Yeoh, B. S., Olvera, R. A., Singh, V., Xiao, X., Kennett, M. J., Joe, B., Lambert, J. D., & Vijay–Kumar, M. (2016) · American Journal Of Pathology · doi:10.1016/j.ajpath.2015.12.004 · Cited by 49
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Kumar, A., & Brookes, M. (2020) · Nutrients · doi:10.3390/nu12113478 · Cited by 53
The effect of iron therapy on oxidative stress and intestinal microbiota in inflammatory bowel diseases: A review on the conundrum
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Ursodeoxycholic Acid versus Sulfasalazine in Colitis-Related Colon Carcinogenesis in Mice
Kohno, H., Suzuki, R., Yasui, Y., Miyamoto, S., Wakabayashi, K., & Tanaka, T. (2007) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-06-2727 · Cited by 48
Stimulating erythropoiesis in inflammatory bowel disease associated anemia
Tsiolakidou, G. (2007) · World Journal of Gastroenterology · doi:10.3748/wjg.v13.i36.4798 · Cited by 47
Inflammatory Bowel Disease: A Model of Chronic Inflammation-Induced Cancer
Yang, G., Taboada, S., & Liao, J. (2009) · Methods in molecular biology · doi:10.1007/978-1-59745-447-6_9 · Cited by 46
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Uritski, R., Bilkis, I. I., Reifen, R. M., Barshack, I., & Ghebremeskel, K. (2004) · Journal of Nutrition · doi:10.1093/jn/134.9.2251 · Cited by 46
Cancer in inflammatory bowel disease
Sussman, D. A., Santaolalla, R., Strobel, S., Dheer, R., & Abreu, M. T. (2012) · Current Opinion in Gastroenterology · doi:10.1097/mog.0b013e328354cc36 · Cited by 46
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Xiao, P., Cai, X., Zhang, Z., Guo, K., Ke, Y., Hu, Z., Song, Z., Zhao, Y., Yao, L., Shen, M., et al. (2024) · Advanced Science · doi:10.1002/advs.202306571 · Cited by 43
Macroscopic, microscopic and biochemical characterisation of spontaneous colitis in a transgenic mouse, deficient in the multiple drug resistance 1a gene
Banner, K. H., Cattaneo, C., Net, J.-L. L., Popovic, A., Collins, D., & Gale, J. D. (2004) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0705982 · Cited by 44
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Seril, D. N., Liao, J., West, A. B., & Yang, G. (2006) · Journal of Clinical Gastroenterology · doi:10.1097/00004836-200605000-00006 · Cited by 44
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Latunde-Dada, G. O., Pereira, D. I. A., Tempest, B., Ilyas, H., Flynn, A. C., Aslam, M. F., Simpson, R. J., & Powell, J. J. (2014) · Journal of Nutrition · doi:10.3945/jn.114.201715 · Cited by 42
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Diagnosis and treatment of anemia in patients with inflammatory bowel disease
Mücke, V. T. (2016) · Annals of Gastroenterology · doi:10.20524/aog.2016.0083 · Cited by 43
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Soluble epoxide hydrolase deficiency inhibits dextran sulfate sodium-induced colitis and carcinogenesis in mice.
Zhang, W., Li, H., Dong, H., Liao, J., Hammock, B. D., & Yang, G.-Y. (2013) · PubMed · Cited by 40
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Li, G., Lee, M., Liu, A. B., Yang, Z., Lin, Y., Shih, W. J., & Yang, C. S. (2011) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.12.005 · Cited by 40
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Colorectal carcinoma development in inducible nitric oxide synthase‐deficient mice with dextran sulfate sodium‐induced ulcerative colitis
Seril, D. N., Liao, J., & Yang, G. (2007) · Molecular Carcinogenesis · doi:10.1002/mc.20282 · Cited by 39
Self-citation
Prevention of colitis‐associated carcinogenesis in a mouse model by diet supplementation with ursodeoxycholic acid
Loddenkemper, C., Keller, S., Hanski, M., Cao, M., Jahreis, G., Stein, H., Zeitz, M., & HANSKI, C. (2005) · International Journal of Cancer · doi:10.1002/ijc.21729 · Cited by 39
Nitrotyrosine formation in splenic toxicity of aniline
Khan, M. F., Wu, X., Kaphalia, B. S., Boor, P. J., & Ansari, G. A. S. (2003) · Toxicology · doi:10.1016/j.tox.2003.08.008 · Cited by 38

Authors: Seril, D. N., Liao, J., Ho, K.-L. K., Warsi, A., Yang, C. S., & Yang, G.-Y.
Affiliations: Rutgers, The State University of New Jersey (US)
ORCID: Liao, Jie
Yang, Chung S.
Yang, Guang-Yu
Venue: Digestive Diseases and Sciences
Publisher: Springer Science and Business Media LLC
Published: 2002-06
Volume: 47
Issue: 6
Pages: 1266-1278
ISSN: 0163-2116 (ISSN-L)
1573-2568
DOI: 10.1023/a:1015362228659
OpenAlex: W1591222484
Cited by: 183
References: 37
Citations by year: 2026: 2 · 2025: 4 · 2024: 6 · 2023: 4 · 2022: 9 · 2021: 11 · 2020: 10 · 2019: 9 · 2018: 6 · 2017: 7 · 2016: 7 · 2015: 4 · 2014: 14 · 2013: 11 · 2012: 9
FWCI: 4.43
Type: journal article
Language: en
Open access: closed
Licence: www.springernature.com/gp/researchers/text-and-data-mining (tdm)
www.springernature.com/gp/researchers/text-and-data-mining (vor)
Locations: Digestive Diseases and Sciences (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of Environmental Health Sciences (ES0052)
Topics: Health Sciences › Medicine › Gastroenterology › Inflammatory Bowel Disease
Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
Health Sciences › Medicine › Pharmacology (medical) › Inflammatory mediators and NSAID effects
Keywords: dietary iron supplementation, ulcerative colitis, DSS-induced colitis, colorectal carcinogenesis, nitrosative stress, oxidative stress, inducible nitric oxide synthase, nitrotyrosine, AIN-76A diet
MeSH terms: Animals, Colitis, Ulcerative, Colon, Disease Models, Animal, Dose-Response Relationship, Drug, Female, Mice, Inbred C57BL, Colorectal Neoplasms, Dextran Sulfate, Oxidative Stress, Disease Progression, Iron, Dietary, Dietary Supplements, Mice

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Dietary Iron Supplementation Enhances DSS-Induced Colitis and Associated Colorectal Carcinoma Development in Mice

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