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Depression in Persons with Autism: Implications for Research and Clinical Care
Open accessAbstract
Although several studies have investigated the occurrence of medical and neurological conditions in persons with autism, relatively few reports have focused on the phenomenology and treatment of psychiatric disorders in this population. There is emerging evidence that depression is probably the most common psychiatric disorder that occurs in autistic persons. In this review, we examine the factors that influence the presence of depression in this population, such as the level of intelligence, age, gender, associated medical conditions, and the role of genetic factors and life events. We discuss the various forms of treatment available and highlight the need for early detection.
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“Co-occurring depression among individuals with ASD, especially among those with low IQs, has been associated with an increase in RRBs (Ghaziuddin et al. 2002).”
From The Diagnosis of Autism: From Kanner to DSM-III to DSM-5 and Beyond (2021) · cites this paper as Ghaziuddin et al. 2002
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“Whereas anxiety seemed to reduce from childhood to young adulthood (Davis et al. 2011), the risk for depression seemed to increase with increasing age (Ghaziuddin et al. 2002).”
Metadata
- Authors
- Ghaziuddin, M., Ghaziuddin, N., & Greden, J.
- Affiliations
- University of Michigan (US)
- Corresponding author
- Ghaziuddin, Mohammad
- Venue
- Journal of Autism and Developmental Disorders
- Published
- 2002-08
- Volume
- 32
- Issue
- 4
- Pages
- 299-306
- ISSN
- 0162-3257 (ISSN-L)
- 1573-3432
- OpenAlex
- W1546207985
- Semantic Scholar
- 4d8051a1b77a04b327a9b05e8234d2ee7ec4897b
- Cited by
- 579
- References
- 73
- Citations by year
- 2026: 10 · 2025: 13 · 2024: 14 · 2023: 14 · 2022: 22 · 2021: 22 · 2020: 33 · 2019: 34 · 2018: 24 · 2017: 37 · 2016: 37 · 2015: 47 · 2014: 32 · 2013: 45 · 2012: 33
- FWCI
- 0.69
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of Autism and Developmental Disorders (publishedVersion)
- PubMed (publishedVersion)
- Deep Blue (University of Michigan) (submittedVersion)
- Funders
- Deutsches Krebsforschungszentrum
- National Alliance for Research on Schizophrenia and Depression
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Social Sciences › Psychology › Clinical Psychology › Child and Adolescent Psychosocial and Emotional Development
- Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
- Keywords
- depression, autism spectrum disorder, psychiatric comorbidity, risk factors, intelligence level, gender differences, health conditions, genetic factors, life events, depression treatment, early detection
- MeSH terms
- Antidepressive Agents, Autistic Disorder, Combined Modality Therapy, Major Depressive Disorder, Depressive Disorder, Major, Humans, Psychotherapy, Comorbidity
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