Cited by 86Gastrointestinal motility and disordersMast cells and histaminePain Mechanisms and Treatments

Mast Cell Degranulation Induces Delayed Rectal Allodynia in Rats: Role of Histamine and 5-HT

Coelho, Anne-Marie, Fioramonti, Jean, Bueno, Lionel·1998·Digestive Diseases and Sciences

Abstract

Visceral hypersensitivity is a common feature of functional bowel disorders, where an increased number of mast cells have often been described. Thus, we investigated the effect of an experimental mast cell degranulation induced by BrX-537A on somatic (tail heating) and visceral (rectal distension) sensitivity in rats and the involvement of histamine and/or serotonin on this last response. After BrX-537A administration, the latency of tail withdrawal reflex was shortened within the 2- to 8-hr period. Moreover, BrX-537A reduced the distension volume threshold from 0.8 ml to 0.4 ml inducing allodynia, from 6 to 12 hr after its administration. This effect was suppressed by doxantrazole (mast cell stabilizing agent) and WAY 100635 (5-HT1A receptor antagonist), and reproduced by 5-HTP (5-HT precursor) and 8-OH-DPAT (5-HT1A receptor agonist). However, neither granisetron (5-HT3 receptor antagonist) nor H1, H2, or H3 histamine receptor antagonists modified the BrX-537A-induced allodynia. Consequently, mast cell degranulation initiates a delayed somatic and visceral allodynia, with the participation of serotonin, through 5-HT1A receptor activation, on the visceral response.

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Crossref · 10.1023/a:1018853728251

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48 of 48 references verified0 citation errors · 0 not checkable

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  • Activation of the 5-hydroxytryptamine receptor 1A, rather than histamine receptors, has been implicated in complex abdominal pain mediated by mast cell degranulation.

    “Furthermore, the activation of the 5-hydroxytryptamine receptor 1A (5-HT1A), rather than the histamine receptors, has also been implicated in the complex abdominal pain mediated by mast cell degranulation (82).”

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Authors
Coelho, A.-M., Fioramonti, J., & Bueno, L.
Affiliations
Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement (FR)
Venue
Digestive Diseases and Sciences
Published
1998-04
Volume
43
Issue
4
Pages
727-737
ISSN
  • 0163-2116 (ISSN-L)
  • 1573-2568
OpenAlex
W1588618357
Cited by
86
References
48
Citations by year
2026: 1 · 2025: 1 · 2024: 1 · 2023: 2 · 2022: 1 · 2021: 1 · 2020: 1 · 2019: 2 · 2018: 2 · 2017: 2 · 2016: 2 · 2015: 2 · 2014: 4 · 2013: 1 · 2012: 5
FWCI
3.87
Type
journal article
Language
en
Open access
closed
Locations
  • Digestive Diseases and Sciences (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
  • Life Sciences › Immunology and Microbiology › Immunology › Mast cells and histamine
  • Health Sciences › Medicine › Physiology › Pain Mechanisms and Treatments
Keywords
mast cell degranulation, visceral hypersensitivity, histamine, serotonin, 5-HT1A receptor, doxantrazole, tail withdrawal reflex, functional bowel disorders, 5-hydroxytryptophan, 8-OH-DPAT
MeSH terms
Animals, Histamine, Ionophores, Lasalocid, Male, Mast Cells, Receptors, Serotonin, Rectum, Serotonin, Skin Physiological Phenomena, Time Factors, Cell Degranulation, Rats, Wistar, Pain Threshold, Receptors, Serotonin, 5-HT1, Rats

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