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Cited by 311Gastrointestinal motility and disordersCongenital gastrointestinal and neural anomaliesGastroesophageal reflux and treatments

Fundamentals of neurogastroenterology

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Wood, J D, Alpers, D H, Andrews, P L R·1999·Gut
DOI 10.1136/gut.45.2008.ii6PMC PMC1766686
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Abstract

Current concepts and basic principles of neurogastroenterology in relation to functional gastrointestinal disorders are reviewed. Neurogastroenterology is emphasized as a new and advancing subspecialty of clinical gastroenterology and digestive science. As such, it embraces the investigative sciences dealing with functions, malfunctions, and malformations in the brain and spinal cord, and the sympathetic, parasympathetic and enteric divisions of the autonomic innervation of the digestive tract. Somatomotor systems are included insofar as pharyngeal phases of swallowing and pelvic floor involvement in defecation, continence, and pelvic pain are concerned. Inclusion of basic physiology of smooth muscle, mucosal epithelium, and the enteric immune system in the neurogastroenterologic domain relates to requirements for compatibility with neural control mechanisms. Psychologic and psychiatric relations to functional gastrointestinal disorders are included because they are significant components of neurogastroenterology, especially in relation to projections of discomfort and pain to the digestive tract.

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  • The parasympathetic system may activate defensive programs such as fear-induced bradycardia, nausea, vomiting or diarrhea, and expulsion of urine by the bladder that work alongside the sympathetic system to defend the body from danger.

    “The parasympathetic system may now activate defensive programsfear-induced bradycardia in the heart; nausea, vomiting, or diarrhea programs in the gut; expulsion of urine by the bladder -that work alongside the sympathetic system to defend the body from danger (Kozlowska et al., 2015;Wood et al., 1999).”

    From Physiological feelings (2019) · cites this paper as Wood et al., 1999

    The sections “Nausea and vomiting” and “Neuroimmunophysiologic paradigm for functional gastrointestinal disorders” describe neural programs for emesis and intestinal defense, including diarrhea and expulsion of intestinal threats (page numbers unavailable). The copy does not support fear-induced bradycardia, bladder emptying, or the broader claim that these programs work alongside the sympathetic system to defend the body from danger. (LLM, conf=0.88)

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Cites

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Research works printed but not linked: 45

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Cited by

Sorted by citations

Authors
Wood, J. D., Alpers, D. H., & Andrews, P. L. R.
Affiliations
Washington University in St. Louis (US)
Corresponding author
Wood, J D
ORCID
Venue
Gut
Publisher
BMJ
Published
1999-09-01
Volume
45
Issue
suppl 2
Pages
II6-II16
ISSN
  • 0017-5749 (ISSN-L)
  • 1468-3288
DOI
10.1136/gut.45.2008.ii6
PMC
PMC1766686
OpenAlex
W2004818680
Cited by
311
References
2
Citations by year
2026: 3 · 2025: 3 · 2024: 6 · 2023: 8 · 2022: 7 · 2021: 10 · 2020: 8 · 2019: 8 · 2018: 11 · 2017: 9 · 2016: 9 · 2015: 7 · 2014: 8 · 2013: 7 · 2012: 19
FWCI
2.72
Type
journal article
Language
en
Open access
Locations
  • Gut (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • HighWire Press Open Archive (submittedVersion)
Topics
  • Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
  • Health Sciences › Medicine › Surgery › Congenital gastrointestinal and neural anomalies
  • Health Sciences › Medicine › Gastroenterology › Gastroesophageal reflux and treatments
Keywords
neurogastroenterology, functional gastrointestinal disorders, enteric nervous system, brain-gut interaction, swallowing, pelvic floor dysfunction, defecation, continence, pelvic pain, smooth muscle physiology, mucosal epithelium, psychosomatic pain
MeSH terms
Colonic Diseases, Functional, Digestive System, Digestive System Physiological Phenomena, Humans, Mast Cells, Motor Neurons, Enteric Nervous System

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