Preliminary findings suggest the number and volume of supragranular and infragranular pyramidal neurons are similar in the anterior superior temporal area of control subjects and subjects with autism
Open accessAbstract
We investigated the cytoarchitecture of the anterior superior temporal area (TA2) of the postmortem cerebral cortex in 9 subjects with autism and 9 age-matched typically developing subjects between the ages of 13 and 56 years. The superior temporal gyrus is involved in auditory processing and social cognition and its pathology has been correlated with autism. We quantified the number and soma volume of pyramidal neurons in the supragranular layers and pyramidal neurons in the infragranular layers in each subject. We did not find significant differences in the number or volume of supragranular or infragranular neurons in the cerebral cortex of subjects with autism compared to typically developing subjects. This report does not support an alteration of supragranular to infragranular neurons in autism. However, further stereological analysis of the number of cells and cell volumes in specific cortical areas is needed to better establish the cellular phenotype of the autistic cerebral cortex and to understand its clinical relevance in autism.
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No differences in number and soma volume of pyramidal neurons in supragranular and infragranular layers of the anterior superior temporal area are found between ASD adolescents/adults and age-matched neurotypical individuals.
“Results showed no differences between ASD adolescents and adults age-matched with a neurotypical group (Kim et al. 2015).”
From Autism Spectrum Disorder and auditory sensory alterations: a systematic review on the integrity of cognitive and neuronal functions related to auditory processing (2023) · cites this paper as Kim et al. 2015
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- Authors
- Kim, E., Camacho, J., Combs, Z., Ariza, J., Lechpammer, M., Noctor, S. C., & Martínez-Cerdeño, V.
- Affiliations
- Shriners Hospitals for Children - Northern California (US)
- University of California, Davis (US)
- Venue
- Neuroscience Letters
- Publisher
- Elsevier BV
- Published
- 2015-03
- Volume
- 589
- Pages
- 98-103
- ISSN
- 0304-3940 (ISSN-L)
- PMC
- PMC4336808
- OpenAlex
- W2013494683
- Cited by
- 17
- References
- 34
- Citations by year
- 2026: 1 · 2024: 2 · 2023: 3 · 2021: 2 · 2020: 1 · 2019: 1 · 2017: 3 · 2016: 4
- FWCI
- 1.40
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Neuroscience Letters (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- NIH (R01 MH094681)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- autism spectrum disorder, pyramidal neurons, supragranular layers, infragranular layers, cortical cytoarchitecture, superior temporal gyrus, postmortem brain, stereology
- MeSH terms
- Adolescent, Adult, Autistic Disorder, Cell Count, Humans, Male, Middle Aged, Temporal Lobe, Case-Control Studies, Pyramidal Cells, Cell Size, Young Adult
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