Cited by 316Wound Healing and TreatmentsSkin Protection and AgingDermatologic Treatments and Research

The DOI matches its Crossref record; 78 of the 78 references it cites were found in a registry or an index.

Ageing and wound healing

Ashcroft, Gillian S., Mills, Stuart J., Ashworth, Jason J.·2002·Biogerontology

Open this paper in CoChat — free account

Abstract

Cutaneous wound healing is a complex process encompassing a number of overlapping events including leukocyte recruitment, matrix deposition, epithelialization, and ultimately resolution of inflammation with the formation of a mature scar. Morbidity associated with age-related delayed wound healing imposes an enormous social and financial burden; unless improved wound care strategies are developed the projected relative and absolute increase in the elderly population will further exacerbate this problem. In recent years insight has been gained into the impact of ageing on cellular and tissue responses, resulting from impaired cytokine signal transduction, unchecked inflammation, an altered balance of protein synthesis and degradation, and subsequent downstream effects on the rate and quality of the wound healing response. Further understanding of the complex interaction between the ageing cell and its microenvironment is essential in order to develop focussed therapeutic strategies to improve healing in the elderly.

Integrity signals

Registry

Crossref · 10.1023/a:1021399228395

Cites

78 of 78 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Longevity, Stress Response, and Cancer in Aging Telomerase-Deficient Mice
Rudolph, K. L., Chang, S., Lee, H.-W., Blasco, M., Gottlieb, G. J., Greider, C., & DePinho, R. A. (1999) · Cell · doi:10.1016/s0092-8674(00)80580-2 · Cited by 1,349 · cited 2×
“In the telomerase null mouse age-dependent telomere shortening and accompanying genetic instability were associated with shortened life span as well as a reduced capacity to respond to stresses such as wound healing ( Rudolph et al. 1999; Gonzalez-Suarez et al. 2001), whereas the epidermis of telomerase-transgenic mic…”
Background
Transforming growth factor type beta induces monocyte chemotaxis and growth factor production.
Wahl, S. M., Hunt, D. A., Wakefield, L. M., McCartney-Francis, N. L., Wahl, L. M., Roberts, A. B., & Sporn, M. B. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.16.5788 · Cited by 1,256
Matrix Metalloproteinase-2 Is an Interstitial Collagenase
Aimes, R. T., & Quigley, J. P. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.11.5872 · Cited by 944
Mice lacking Smad3 show accelerated wound healing and an impaired local inflammatory response
Ashcroft, G. S., Yang, X., Glick, A. B., Weinstein, M., Letterio, J. J., Mizel, D. E., Anzano, M., Greenwell-Wild, T., Wahl, S. M., Deng, C., et al. (1999) · Nature Cell Biology · doi:10.1038/12971 · Cited by 911
Self-citation
Wound Fluid from Chronic Leg Ulcers Contains Elevated Levels of Metalloproteinases MMP-2 and MMP-9
Wysocki, A. B., Staiano-Coico, L., & Grinnell, F. (1993) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12359590 · Cited by 732
Cell migration is essential for sustained growth of keratinocyte colonies: The roles of transforming growth factor-α and epidermal growth factor
Barrandon, Y., & Green, H. (1987) · Cell · doi:10.1016/0092-8674(87)90179-6 · Cited by 693
Estrogen accelerates cutaneous wound healing associated with an increase in TGF-β1 levels
Ashcroft, G. S., Dodsworth, J., Boxtel, E. V., Tarnuzzer, R. W., Horan, M. A., Schultz, G. S., & Ferguson, M. W. J. (1997) · Nature Medicine · doi:10.1038/nm1197-1209 · Cited by 573
Self-citation
Structural and functional changes of normal aging skin
Fenske, N. A., & Lober, C. W. (1986) · Journal of the American Academy of Dermatology · doi:10.1016/s0190-9622(86)70208-9 · Cited by 535
Sequential appearance of fibronectin and collagen in experimental granulation tissue.
Kurkinen, M. T., Vaheri, A. I., Roberts‎, P., & Stenman, S. (1980) · PubMed · Cited by 447
Senescence in innate immune responses: reduced neutrophil phagocytic capacity and CD16 expression in elderly humans
Butcher, S. K., Chahal, H., Nayak, L., Sinclair, A., Henriquez, N. V., Sapey, E., O'Mahony, D., & Lord, J. M. (2001) · Journal of Leukocyte Biology · doi:10.1189/jlb.70.6.881 · Cited by 436

Flagged first, then by citations

Show all 78 references

Research works printed but not linked: 3

Compton CC (1993) Wound healing potential of cultured epithelium. Wounds Compend Skin Res Pract 5: 97-111
Katsuda S, Okada Y, Okada Y, Imai K and Nakanishi I (1994) matrix metalloproteinase-9 can degrade arterial elastin. Am J Pathol 145: 1208-1218
Pieraggi MJ, Bouissou H, Angelier C, Uhart D, Magnol J and Kokolo J (1985) Le fibroblaste. Ann Path 5: 65-76

Sorted by citations

Items 201–300 of 316

The Importance of Sex-Based Comparisons in Preclinical Nanomedicine and Regenerative Chronic Wound Therapies
Mahmoudi, N., Saeed, M. H., Peereboom, L., Liu, X., Nisbet, D. R., & Mahmoudi, M. (2025) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.5c00996 · Cited by 8
Keratinocyte Integrin α3β1 Promotes Efficient Healing of Wound Epidermis
Dhulipalla, S., Duarte, G. A., Wu, L., DiPersio, M. R., Lamar, J. M., DiPersio, C. M., & Longmate, W. M. (2024) · JID Innovations · doi:10.1016/j.xjidi.2024.100310 · Cited by 8
Oral Administration of Nacre Extract from Pearl Oyster Shells Has Anti-Aging Effects on Skin and Muscle, and Extends the Lifespan in SAMP8 Mice
Yamamoto, H., Shimomura, N., & Hasegawa, Y. (2024) · Pharmaceuticals · doi:10.3390/ph17060713 · Cited by 8
Toxicological evaluation of the effects of 2-stroke auto-rickshaw smoke solutions on wound healing
Ejaz, S., Iqbal, A., Rahman, S. A., Bari, F., Ashraf, M. A., Nawaz, M., Lim, C. W., & Kim, B. (2008) · Environmental Toxicology and Pharmacology · doi:10.1016/j.etap.2008.12.003 · Cited by 8
Exercise influences the impact of polychlorinated biphenyl exposure on immune function
Pillai, M. R., Keylock, K. T., Cromwell, H. C., & Meserve, L. A. (2020) · PLoS ONE · doi:10.1371/journal.pone.0237705 · Cited by 8
Wearable device for iontophoretic treatment and monitoring of pressure ulcers: Proof-of-concept
Chaudon, M.-J., Hulea, O., Yakoub, A., Monnier, P., & Saadaoui, M. (2022) · Medical Engineering & Physics · doi:10.1016/j.medengphy.2022.103861 · Cited by 8
Facilitating Positive Outcomes in Older Adults with Wounds
Stotts, N. A., & Hopf, H. W. (2005) · Nursing Clinics of North America · doi:10.1016/j.cnur.2004.09.005 · Cited by 8
Research progress on the role of fascia in skin wound healing
Xu, J., Zhang, H., & Ye, H. (2025) · Burns & Trauma · doi:10.1093/burnst/tkaf002 · Cited by 7
A bell-shaped dose–response of topical FGF-1 in accelerating dermal wound healing in aged female BALB/cByJ mice
Hagerott, B. N., Blumstein, A. J., McGarry, L. E., Cohen, H. M., Tenorio, C. A., Powell, B. D., Nagy, T., & Blaber, M. (2020) · Journal of Proteins and Proteomics · doi:10.1007/s42485-020-00040-z · Cited by 7
Wound Healing in the Elderly
Engeland, C. G., & Gajendrareddy, P. K. (2011) · Springer eBooks · doi:10.1007/978-1-4419-0892-6_19 · Cited by 7
Cisterna magna arachnoid membrane suturing decreases incidence of pseudomeningocele formation and incisional CSF leakage
Pitskhelauri, D. I., Kudieva, E. S., Moshchev, D., Ананьев, Е. П., Shifrin, M. A., Danilov, G., Melnikova-Pitskhelauri, T. V., Kachkov, I. A., Bykanov, A., & Sanikidze, A. Z. (2018) · Acta Neurochirurgica · doi:10.1007/s00701-018-3507-y · Cited by 7
6.13 Tissue Engineering of Muscle Tissue ☆
Conboy, I. M., Freimer, J. W., Weisenstein, L., Liu, Y., Mehdipour, M., & Gathwala, R. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-803581-8.10178-x · Cited by 7
Challenges in conducting research on sexual violence and HIV and approaches to overcome them
Aldous, A. M., Magnus, M., Roberts, A. D., DeVore, H. K., Moriarty, T., Schultz, C. H., Zumer, M., Simon, G. L., & Ghosh, M. (2017) · American Journal of Reproductive Immunology · doi:10.1111/aji.12699 · Cited by 7
Capillary alginate gel (Capgel™) for the treatment of full-thickness dermal wounds in a hypoxic mouse model
Bosak, A. J., Kwan, M. W. C., Willenberg, A. R., Perle, K. M. D. L., Weinstein, D. A., Hines, R. B., Schultz, G. S., Ross, E. A., & Willenberg, B. J. (2018) · International Journal of Polymeric Materials · doi:10.1080/00914037.2018.1534112 · Cited by 7
Age-Dependent Changes in Skeletal MuscleRegeneration
Brack, A. S., & Rando, T. A. (2008) · Springer eBooks · doi:10.1007/978-1-4020-6768-6_16 · Cited by 7
Tissue Engineering of Muscle Tissue
Conboy, I. M., Freimer, J. W., & Weisenstein, L. (2011) · Elsevier eBooks · doi:10.1016/b978-0-08-055294-1.00176-8 · Cited by 6
Epidermal Growth Factor Therapy Impact on Scar Tissue Resilience of Diabetic Lower Limbs Ulcers-An Enlightening Hypothesis
Acosta, J. B., Mendoza‐Marí, Y., Ojalvo, A. G., Fernández‐Mayola, M., & Nieto, G. G. (2018) · Journal of Diabetes & Metabolism · doi:10.4172/2155-6156.1000798 · Cited by 6
Cleft Repair in Adults
Fuller, J., Drake, D., Felstead, A., & Colbert, S. D. (2016) · The Cleft Palate-Craniofacial Journal · doi:10.1597/16-38 · Cited by 6
The fourth state of matter: Plasma and applications of atmospheric pressure cold plasmas ın dentistry
Küçük, D., Ercan, U. K., & Köseoğlu, S. (2018) · Yeditepe Dental Journal · doi:10.5505/yeditepe.2018.09609 · Cited by 6
Effects of PTEN on the longevity of cultured human umbilical vein endothelial cells: The role of antioxidants
Tait, I., Li, Y., & Lu, J. (2014) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2014.1999 · Cited by 6
The Treatment of Periodontal Diseases in Elderly Patients
Grusovin, M. G. (2019) · Oral Rehabilitation for Compromised and Elderly Patients · doi:10.1007/978-3-319-76129-9_3 · Cited by 5
Evaluating Soft Tissue Healing after Implant Placement Using Two Different Mouthwashes (Myrrh and Chlorhexidine Gluconate): A Randomized Control Trial
Ibraheem, W., Hakami, A. A., Shafei, A. A., Jerah, S. A., Almarghlani, A. A., Makrami, A. M., & Bhati, A. K. (2022) · Medicina · doi:10.3390/medicina58101351 · Cited by 5
Skin care: Incontinence dermatitis
Nazarko, L. (2007) · Nursing and Residential Care · doi:10.12968/nrec.2007.9.7.23838 · Cited by 5
Anatomy and Physiology
Snow, C. E., Goettsche, K. R., & Avari, J. (2018) · Springer eBooks · doi:10.1007/978-3-319-73078-3_8 · Cited by 5
Korrekturm�glichkeiten der gest�rten Wundheilung
Becker, H. D., Coerper, S., & Beckert, S. (2004) · Der Chirurg · doi:10.1007/s00104-004-0843-7 · Cited by 5
A multi-component herbal preparation (PADMA 28) improves structure/function of corticosteroid-treated skin, leading to improved wound healing of subsequently induced abrasion wounds in rats
Aslam, M. N., Warner, R. L., Bhagavathula, N., Ginsburg, I., & Varani, J. (2010) · Archives of Dermatological Research · doi:10.1007/s00403-010-1066-z · Cited by 5
Early wound healing at 1 week postoperatively in periodontal tissue regeneration therapy: enamel matrix derivative versus recombinant human fibroblast growth factor
Nakayama, Y., Ogihara-Takeda, M., Saito, Y., Yamaguchi, A., & Ogata, Y. (2024) · Journal of Periodontal & Implant Science · doi:10.5051/jpis.2400740037 · Cited by 4
Trying times: domestication of healthcare technologies amidst challenging dynamic contexts
Fox, S. (2019) · Social Theory & Health · doi:10.1057/s41285-019-00107-y · Cited by 4
Comparison of early wound healing using modified papilla preservation technique between enamel matrix derivative and recombinant human fibroblast growth factor
Nakayama, Y., Tabe, S., Igarashi, K., Moriya, S., Katsumata, T., Kobayashi, R., Nakagawa, S., Nishino, T., Fukuoka, N., Hosono, K., et al. (2023) · Journal of Periodontal & Implant Science · doi:10.5051/jpis.2303080154 · Cited by 4
Molecular Regulation and Rejuvenation of Muscle Stem (Satellite) Cell Aging
Meiliana, A., Dewi, N. M., & Wijaya, A. (2015) · The Indonesian Biomedical Journal · doi:10.18585/inabj.v7i2.73 · Cited by 4
The effects of ageing on fibroblast function during proliferation
Brown, J. A. (2004) · Journal of Wound Care · doi:10.12968/jowc.2004.13.3.26586 · Cited by 4
Dicarbonyl-mediated protein modifications affect matrix metalloproteinase (MMP) activity
Bartling, B., Desole, M., Silber, R.-E., & Simm, A. (2007) · Zeitschrift für Gerontologie und Geriatrie · doi:10.1007/s00391-007-0485-8 · Cited by 4
Improving Senescent Wound Healing With Local and Systemic Therapies
Szpalski, C., Butala, P., Vandegrift, M. T., Knobel, D., Allen, R. J., Saadeh, P. B., & Warren, S. M. (2018) · Annals of Plastic Surgery · doi:10.1097/sap.0000000000001473 · Cited by 4
A chronic low dose of Δ9-tetrahydrocannabinol (3 mg / kg / 21 d) reorganizes the disturbed wound healing process and accelerates wound closure in old female mice
Plum, M., Beier, J. P., & Ruhl, T. (2025) · Experimental Gerontology · doi:10.1016/j.exger.2025.112832 · Cited by 3
Microcirculation in Wound Healing
MAYROVITZ, H. N., & Aoki, K. C. (2025) · Physiology in health and disease · doi:10.1007/978-3-031-99609-2_10 · Cited by 3
Oral wound healing in the elderly: Mechanisms, challenges, and innovations
Decker, A. M., Stuhr, S. H., Ávila‐Ortiz, G., Pilloni, A., Marini, L., CASTILHO, R. M., Wallace, B. I., & Kapila, Y. L. (2026) · Periodontology 2000 · doi:10.1111/prd.70027 · Cited by 3
Evaluation of the wound healing effect of Nishamalaki, an Ayurvedic formulation comprising Curcuma longa and Phyllanthus emblica in aging rats
Panda, V., Vaswani, L., Sudhamani, S., Hingorani, L., & Deshmukh, A. (2024) · Clinical Phytoscience · doi:10.1186/s40816-024-00367-w · Cited by 3
Fine-Sampled Photographic Quantitation of Dermal Wound Healing Senescence in Aged BALB/cByJ Mice and Therapeutic Intervention with Fibroblast Growth Factor-1
Mellers, A. P., Tenorio, C. A., Lacatusu, D. A., Powell, B. D., Patel, B. N., Harper, K. M., & Blaber, M. (2018) · Advances in Wound Care · doi:10.1089/wound.2018.0801 · Cited by 3
Ageing impairs restoration of endometrial blood flow impedance after laparoscopic myomectomy in infertile women with uterine fibroids
Ota, K., Sato, K., Shiraishi, S., & Takahashi, T. (2021) · Journal of Obstetrics and Gynaecology · doi:10.1080/01443615.2021.1945011 · Cited by 3
Surgical outcomes in patients aged 70 years and older following uterosacral ligament suspension: a comparative study
Chill, H. H., Dick, A., Cohen, A., Ryvkin, I., Rosenbloom, J. I., Salzman, A. R., & Shveiky, D. (2023) · Archives of Gynecology and Obstetrics · doi:10.1007/s00404-023-06974-1 · Cited by 3
Synthesis and characterization of nanoherbal formulations for topical wound healing applications
Pandey, V., Barve, K. H., & Londhe, V. Y. (2023) · Elsevier eBooks · doi:10.1016/b978-0-323-99527-6.00012-4 · Cited by 3
Simultaneous Skin Rejuvenation in Patients Undergoing Medical Treatment for Actinic Keratosis and Non-Melanoma Skin Cancer: A Case Series Analysis
Sciamarrelli, N., Rosset, F., Boskovic, S., Borriello, S., Mastorino, L., Ribero, S., Quaglino, P., & Broganelli, P. (2023) · Cosmetics · doi:10.3390/cosmetics11010003 · Cited by 3
External influences on ageing skin health
Lawton, S. (2011) · Nursing and Residential Care · doi:10.12968/nrec.2011.13.11.522 · Cited by 3
Tissue-Specific Ageing of Rat Tendon-Derived Progenitor Cells
Scutt, N., Johnson, A. A., & Scutt, A. M. (2015) · Journal of Stem Cell Research & Therapy · doi:10.4172/2157-7633.1000309 · Cited by 3
Combined Ultrasound and Electric Field Stimulation Aids the Healing of Chronic Pressure Ulcers
Rosenblum, J. I., & Papamichael, M. (2016) · Journal of Gerontology & Geriatric Research · doi:10.4172/2167-7182.1000319 · Cited by 3
Postamputation Pain in the Geriatric Population
Siefferman, J. W. (2013) · Topics in Pain Management · doi:10.1097/01.tpm.0000427292.89347.f6 · Cited by 2
Suprathel Versus Hypafix in the Management of Split-Thickness Donor Site Wounds in the Elderly: A Randomised Controlled Trial
Cussons, D., Sullivan, J., Frew, Q., & Barnes, D. (2024) · European Burn Journal · doi:10.3390/ebj5040031 · Cited by 2
CD4 expression controls epidermal stem cell balance
Brandes, N., Hahn, H., & Uhmann, A. (2025) · Scientific Reports · doi:10.1038/s41598-025-87915-7 · Cited by 2
Metformin promotes wound healing in senescent fibroblasts by regulating SIRT1 and FAP-α
Çetinavcı, D., Yaşar, V., Yiğittürk, G., & Elbe, H. (2025) · Histochemistry and Cell Biology · doi:10.1007/s00418-025-02431-z · Cited by 2
Bioactive peptide matrikines: discovery approaches for skin rejuvenation
Birtles, T., El-Houni, Z., Mistry, K., Ozols, M., Bradley, E. J., Bell, M., Swift, J., Sherratt, M. J., & Eckersley, A. (2026) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00881.2025 · Cited by 2
Treatment of striae albae with combination of fractional radiofrequency and topical tretinoin: A randomized controlled trial
Grove, G. L., Karmisholt, K. E., Philipsen, P. A., Bjerring, P., & Hædersdal, M. (2026) · Lasers in Medical Science · doi:10.1007/s10103-026-04975-5 · Cited by 2
Endoscopic push through tragal cartilage tympanoplasty: A 10-year retrospective review of our technique and outcomes
Rahman, K. M. A., Majeed, K., Finnegan, E. A., & Keogh, I. J. (2024) · World Journal of Otorhinolaryngology · doi:10.5319/wjo.v11.i2.18 · Cited by 2
3D-cultured DFAT spheroid-derived exosomes promote aged wound healing via modulation of the NF-κB/Serpine1 pathway
Ma, X., Wei, W., Zeng, H., & Dong, M. (2025) · Tissue and Cell · doi:10.1016/j.tice.2025.103049 · Cited by 2
Enhanced RNA quality control maintains long-term regenerative ability in planarians
Zelko, M., Li, D., Parambil, S. A., Poulet, A., Verdesca, A. D., Mazeika, K., Dasgupta, K., & van Wolfswinkel, J. C. (2025) · Development · doi:10.1242/dev.204762 · Cited by 2
Pathophysiologie der Wundheilung und modernes Wundmanagement im urologischen Kontext
Wicke, C., Schilling, D., Feyerabend, S., Königsrainer, A., & Stenzl, A. (2007) · Der Urologe · doi:10.1007/s00120-007-1593-1 · Cited by 2
Nitric oxide effects on the function of aged cells ex vivo and in vivo.
Reed, M. J., Eyman, D., & Karres, N. (2008) · PubMed · Cited by 2
Effects of Ginger (Zingiber officinale) on Skin Conditions:
(2013) · Journal of the Turkish Academy of Dermatology · doi:10.6003/jtad.1372r2 · Cited by 2
Impaired integumentary integrity
Rabbia, J. (2011) · Elsevier eBooks · doi:10.1016/b978-0-323-02948-3.00028-6 · Cited by 2
Stress and Wound Healing: Animal Models
Padgett, D. A., Marucha, P. T., & Sheridan, J. F. (2007) · Elsevier eBooks · doi:10.1016/b978-012088576-3/50046-0 · Cited by 2
Pathogenic bacteria of diabetic-associated infections and their pathogenesis
Khazaal, S. S., Talha, M. H. Z., & Raheem, A. A. (2020) · Reviews in Medical Microbiology · doi:10.1097/mrm.0000000000000222 · Cited by 2
Hard-to-heal ulcers treated with hypochlorous acid oxidising solution and standard of care: a 32-week follow-up
Ricci, E., & Pittarello, M. (2021) · Journal of Wound Care · doi:10.12968/jowc.2021.30.10.840 · Cited by 2
Presurgical Orthopedic Treatment of a 3-Year-Old Child with Unoperated Complete Bilateral Cleft Lip and Palate and Protruding Premaxilla
Radojičić, J., Trifunović, B., Čutović, T., & Radojičić, A. (2022) · The Cleft Palate-Craniofacial Journal · doi:10.1177/10556656221074190 · Cited by 2
Skin damage in the aged: it’s more than cosmetic
Varani, J. (2009) · Expert Review of Dermatology · doi:10.1586/edm.09.58 · Cited by 2
Therapie pathologischer Narben
Riedemann, H. I., Schmidt, M. F., & Baron, J. M. (2023) · JDDG Journal der Deutschen Dermatologischen Gesellschaft · doi:10.1111/ddg.15088_g · Cited by 1
Financial Aspects of Elderly Care that Enhances their Quality of Life: A Scientometric Review
Azmi, A. C., Hong, O. K., Aziz, N. A., Shahimi, S., & Ling, L. W. (2023) · Journal of Scientometric Research · doi:10.5530/jscires.12.3.067 · Cited by 1
Physiology of Wound Healing and Clinical Considerations
Lopez, D. J. (2024) · Wiley eBooks · doi:10.1002/9781119933861.ch2 · Cited by 1
Redox state of aging skin: A double-edged sword in wound healing
Chen, Q., Sophabmixay, A., Albertson, T., Ghasb, G., Terzian, A., Yan, L., Young, L. H., & Barsotti, R. (2024) · Advances in biogerontology · doi:10.1016/bs.abger.2024.05.008 · Cited by 1
The perioperative management of geriatric patients in transplantation surgery—clinical, immunological, and translational considerations
Knoedler, L., Boroumand, S., Hinze, C. A., Knoedler, S. A., Lellouch, A. G., Maheta, B. J., Iske, J., & Panayi, A. C. (2025) · Frontiers in Transplantation · doi:10.3389/frtra.2025.1566466 · Cited by 1
Collapsed fibroblasts in aged human skin in vivo: A critical driver of dermal aging
Quan, T., Wang, F., Marella, S., Billi, A. C., Qin, Z., Weng, S., Fu, J., Gudjonsson, J. E., Voorhees, J. J., & Fisher, G. J. (2026) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2026.07.028 · Cited by 1
Cell and Tissue Destruction in Selected Disorders
Arnhold, J. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-816388-7.00009-7 · Cited by 1
Mesenchymal Stem Cells Therapeutic Applications in Integumentary System Disorders
Gugjoo, M. B. (2022) · Springer eBooks · doi:10.1007/978-981-19-3277-9_11 · Cited by 1
THE CONTENT OF METALLOPROTEINASE-2 AND METALLOPROTEINASE-9 IN THE SKIN OF RATS OF DIFFERENT AGES AFTER CLOSURE OF THE WOUND BED
Hrytsevych, N., Vereshchaka, V. V., Nikitina, N., Stepanova, L. I., & Beregova, T. V. (2022) · Wiadomości Lekarskie · doi:10.36740/wlek202208206 · Cited by 1
Histological and morphological development of the prepuce from birth to prepubertal age
Erdem, E., Caliskan, M. K., Karagül, M. İ., Akbay, E., Yılmaz, B. C., & Aygün, C. (2024) · Korean journal of urology · doi:10.4111/icu.20230034 · Cited by 1
The effects of Phosphatase and Tensin Homolog (PTEN) overexpression on longevity of cultured Human Umbilical Vein Endothelial Cells (HUVEC)
Tait, I. (2014) · Tuwhera (Auckland University of Technology)
Influencia de las fuerzas oclusales sobre la reabsorción radicular en dientes con enfermedad periodontal
Vázquez, E. C. (2011) · Tesis Doctorals en Xarxa (Consorci de Serveis Universitaris de Catalunya)
Avaliação do efeito da Artin M no processo de repação em mucosa mastigatória
Kim, Y. J. (2011) · Americanae (AECID Library)
Cellular mechanisms of myofibroblast differentiation and dysfunctions in wound healing
Midgley, A. C. (2014) · ORCA Online Research @Cardiff (Cardiff University)
Control of normal and abnormal proliferation in the epidermis: EGF receptor function and epidermal hyperplasia
Varani, J. (2007) · Expert Review of Dermatology · doi:10.1586/17469872.2.5.629
The benefits of a self-management telephone based intervention for promoting exercise and healing rates for venous leg ulcer patients
O’Brien, J. (2015)
Special Considerations in Lung Transplantation in Older Patients
Floreth, T., & Bhorade, S. M. (2011) · Humana Press eBooks · doi:10.1007/978-1-60761-727-3_13
Wound Healing as We Age
Rahal, J. A., & Nassar, D. (2015) · Springer eBooks · doi:10.1007/978-3-642-27814-3_143-1
Dermal Connective Tissue as the Foundation for Healthy-Looking Skin
Varani, J. (2009) · Elsevier eBooks · doi:10.1016/b978-0-8155-2029-0.50021-1
Approach and management modalities in Esophageal Perforations
Desai, R., Srivastava, R., Chitrapu, C., Kaleemuddin, M., & Amenha, C. (2018) · International Surgery Journal · doi:10.18203/2349-2902.isj20180333
Caracterização do perfil de síndromes dolorosas, psicofísica e medidas de excitabilidade cortical em doentes com neuromielite óptica controlada
Valério, F. (2019) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.5.2019.tde-01072019-150317
AGED MUSCLE ECM RECAPITULATES ALTERED HOST RESPONSE OBSERVED IN AGED MUSCLE INJURY
LoPresti, S. T. (2019) · D-Scholarship@Pitt (University of Pittsburgh)
Evaluation of wound healing activity of dalbergia sisso leaves in alloxan induced hyperglycemic rats
Soni, P., Qureshi, Z., Masood, M., & Jain, S. (2020) · Journal of Emerging Technologies and Innovative Research
Tissue repair and stress responses of aged skin epidermis
Wong, W. (2020) · Digital Repository Service (Northeastern University) · doi:10.17760/d20383670
The Age-Dependent Characterization of the ER-Alpha Positive Breast Cancer Tumor Microenvironment
Hamel, K. M. (2021) · Louisiana State University · doi:10.31390/gradschool_dissertations.5482
Wound Healing Activity Of Extract Of Gratiola Officinalis In Vivo
Mylnikov, A. M., Mudrak, D. A., Наволокин, Н. А., Khramova, Y. A., Bucharskaya, A. B., Polukonova, N. V., & Maslyakova, G. N. (2021) · Russian Open Medical Journal · doi:10.15275/rusomj.2021.0413
Wound Healing as We Age
Rahal, J. A., & Nassar, D. (2016) · Springer eBooks · doi:10.1007/978-3-662-47398-6_143
Ageing decreases the healing of wounds in the skin of alcohol-preferring rats
Martinez, F. E., Cassettari, L. L., Nicolaua, N. C., Camargo, V. M. D. B., Chuffaa, L. G. D. A., Pinheiro, P. F. F., Padovania, C. R., & Martinez, M. (2022) · Journal of Wound Care · doi:10.12968/jowc.2022.31.10.872
Does Gingival Carcinoma in the Elderly Correspond to a Distinct Entity?
MEUNIER, A. (2023) · Journal of Clinical and Medical Surgery · doi:10.52768/2833-5465/1070
Delayed Wound Healing in Aged Mice is Associated with Traumatic Stress, not with EGFR Block
Fuentes, D. (2023) · Journal on Surgery · doi:10.52768/2691-7785/1084
Etude et développement de méthodes préventives et curatives contre les escarres : détection par réseau de capteur sur textile et traitement par patch d'électrostimulation et iontophorèse
Chaudon, M.-J. (2021) · theses.fr (ABES) · doi:10.70675/2bfd65f8ze394z46f4zb13bz01dc5148a644
Traitements des plaies chroniques par plasma froid à pression atmosphérique : étude des mécanismes biologiques mis en jeu
Marchès, A. (2023) · theses.fr (ABES) · doi:10.70675/2cefc9c9zbe72z4d12zb889z811ed3da7deb
Effects of concurrent optical and magnetic stimulation in hard-to-heal wounds: a real-world evidence case series
Neyens, J. C. L., van Heusden, W., Veenendaal, D. V., & Schols, J. M. G. A. (2024) · Journal of Wound Care · doi:10.12968/jowc.2024.0133
Étude de l'homéostasie et de la cicatrisation cutanées du rat-taupe nu (Heterocephalus glaber) au cours du vieillissement
Savina, A. (2023) · theses.fr (ABES) · doi:10.70675/c9a3daa6z8f0az4175z91cez8b6eb43ebf45
New Basic and Translational Perspectives on Skin Repair
Deng, C. (2024) · Frontiers research topics · doi:10.3389/978-2-8325-5494-4
The effect of nitrile gloves on temperature perception during hot water immersion
Cussons, D., Pérusseau-Lambert, A., Frew, Q., Barnes, D., Myers, S. R., & Dziewulski, P. G. (2025) · Burns · doi:10.1016/j.burns.2025.107392
Comparison Between Two Mucoperiosteal Flap Techniques in Repairing Small-to-Medium-Sized Hard Palate Postpalatoplasty Fistulas
Li, Y., Yin, X., Shi, B., Zheng, Q., & Li, J. (2025) · The Cleft Palate-Craniofacial Journal · doi:10.1177/10556656251357460

Authors: Ashcroft, G. S., Mills, S. J., & Ashworth, J. J.
Affiliations: University of Manchester (GB)
Corresponding author: Ashcroft, Gillian S.
ORCID: Mills, Stuart J.
Venue: Biogerontology
Publisher: Springer Science and Business Media LLC
Published: 2002-11
Volume: 3
Issue: 6
Pages: 337-345
ISSN: 1389-5729 (ISSN-L)
1573-6768
DOI: 10.1023/a:1021399228395
OpenAlex: W1530924711
Cited by: 309
References: 78
Citations by year: 2026: 13 · 2025: 20 · 2024: 17 · 2023: 16 · 2022: 14 · 2021: 15 · 2020: 15 · 2019: 19 · 2018: 14 · 2017: 8 · 2016: 8 · 2015: 14 · 2014: 15 · 2013: 11 · 2012: 4
FWCI: 0.96
Type: journal article
Language: en
Open access: closed
Licence: www.springernature.com/gp/researchers/text-and-data-mining (tdm)
www.springernature.com/gp/researchers/text-and-data-mining (vor)
Locations: Biogerontology (publishedVersion)
PubMed (publishedVersion)
Research Explorer (The University of Manchester) (submittedVersion)
Topics: Health Sciences › Medicine › Surgery › Wound Healing and Treatments
Health Sciences › Medicine › Dermatology › Skin Protection and Aging
Health Sciences › Medicine › Dermatology › Dermatologic Treatments and Research
Keywords: aging, skin wound healing, delayed wound healing, older adults, cytokine signaling, chronic inflammation, protein synthesis and degradation, re-epithelialization, scar formation, wound care, cell microenvironment
MeSH terms: Aging, Extracellular Matrix, Humans, Inflammation, Wound Healing, Neovascularization, Physiologic

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Ageing and wound healing

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks