Cited by 316Wound Healing and TreatmentsSkin Protection and AgingDermatologic Treatments and Research

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Ageing and wound healing

Ashcroft, Gillian S., Mills, Stuart J., Ashworth, Jason J.·2002·Biogerontology

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Abstract

Cutaneous wound healing is a complex process encompassing a number of overlapping events including leukocyte recruitment, matrix deposition, epithelialization, and ultimately resolution of inflammation with the formation of a mature scar. Morbidity associated with age-related delayed wound healing imposes an enormous social and financial burden; unless improved wound care strategies are developed the projected relative and absolute increase in the elderly population will further exacerbate this problem. In recent years insight has been gained into the impact of ageing on cellular and tissue responses, resulting from impaired cytokine signal transduction, unchecked inflammation, an altered balance of protein synthesis and degradation, and subsequent downstream effects on the rate and quality of the wound healing response. Further understanding of the complex interaction between the ageing cell and its microenvironment is essential in order to develop focussed therapeutic strategies to improve healing in the elderly.

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Longevity, Stress Response, and Cancer in Aging Telomerase-Deficient Mice
Rudolph, K. L., Chang, S., Lee, H.-W., Blasco, M., Gottlieb, G. J., Greider, C., & DePinho, R. A. (1999) · Cell · doi:10.1016/s0092-8674(00)80580-2 · Cited by 1,349 · cited 2×
“In the telomerase null mouse age-dependent telomere shortening and accompanying genetic instability were associated with shortened life span as well as a reduced capacity to respond to stresses such as wound healing ( Rudolph et al. 1999; Gonzalez-Suarez et al. 2001), whereas the epidermis of telomerase-transgenic mic…”
Background
Transforming growth factor type beta induces monocyte chemotaxis and growth factor production.
Wahl, S. M., Hunt, D. A., Wakefield, L. M., McCartney-Francis, N. L., Wahl, L. M., Roberts, A. B., & Sporn, M. B. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.16.5788 · Cited by 1,256
Matrix Metalloproteinase-2 Is an Interstitial Collagenase
Aimes, R. T., & Quigley, J. P. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.11.5872 · Cited by 944
Mice lacking Smad3 show accelerated wound healing and an impaired local inflammatory response
Ashcroft, G. S., Yang, X., Glick, A. B., Weinstein, M., Letterio, J. J., Mizel, D. E., Anzano, M., Greenwell-Wild, T., Wahl, S. M., Deng, C., et al. (1999) · Nature Cell Biology · doi:10.1038/12971 · Cited by 911
Self-citation
Wound Fluid from Chronic Leg Ulcers Contains Elevated Levels of Metalloproteinases MMP-2 and MMP-9
Wysocki, A. B., Staiano-Coico, L., & Grinnell, F. (1993) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12359590 · Cited by 732
Cell migration is essential for sustained growth of keratinocyte colonies: The roles of transforming growth factor-α and epidermal growth factor
Barrandon, Y., & Green, H. (1987) · Cell · doi:10.1016/0092-8674(87)90179-6 · Cited by 693
Estrogen accelerates cutaneous wound healing associated with an increase in TGF-β1 levels
Ashcroft, G. S., Dodsworth, J., Boxtel, E. V., Tarnuzzer, R. W., Horan, M. A., Schultz, G. S., & Ferguson, M. W. J. (1997) · Nature Medicine · doi:10.1038/nm1197-1209 · Cited by 573
Self-citation
Structural and functional changes of normal aging skin
Fenske, N. A., & Lober, C. W. (1986) · Journal of the American Academy of Dermatology · doi:10.1016/s0190-9622(86)70208-9 · Cited by 535
Sequential appearance of fibronectin and collagen in experimental granulation tissue.
Kurkinen, M. T., Vaheri, A. I., Roberts‎, P., & Stenman, S. (1980) · PubMed · Cited by 447
Senescence in innate immune responses: reduced neutrophil phagocytic capacity and CD16 expression in elderly humans
Butcher, S. K., Chahal, H., Nayak, L., Sinclair, A., Henriquez, N. V., Sapey, E., O'Mahony, D., & Lord, J. M. (2001) · Journal of Leukocyte Biology · doi:10.1189/jlb.70.6.881 · Cited by 436
Topical Estrogen Accelerates Cutaneous Wound Healing in Aged Humans Associated with an Altered Inflammatory Response
Ashcroft, G. S., Greenwell-Wild, T., Horan, M. A., Wahl, S. M., & Ferguson, M. W. J. (1999) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)65217-0 · Cited by 420
Self-citation
Secretory leukocyte protease inhibitor mediates non-redundant functions necessary for normal wound healing
Ashcroft, G. S., Lei, K.-J., Jin, W., Longenecker, G., Kulkarni, A. B., Greenwell‐Wild, T., Hale‐Donze, H., McGrady, G., Song, X.-Y., & Wahl, S. M. (2000) · Nature Medicine · doi:10.1038/80489 · Cited by 416
Self-citation
Extension of the Life-Span of Human Endothelial Cells by an Interleukin-1αAntisense Oligomer
Maier, J. A. M., Voulalas, P. J., Roeder, D., & Maciag, T. (1990) · Science · doi:10.1126/science.2218499 · Cited by 400
Age-Related Alterations in the Inflammatory Response to Dermal Injury
Swift, M. E., Burns, A. L., Gray, K. L., & DiPietro, L. A. (2001) · Journal of Investigative Dermatology · doi:10.1046/j.0022-202x.2001.01539.x · Cited by 398
Increased epidermal tumors and increased skin wound healing in transgenic mice overexpressing the catalytic subunit of telomerase, mTERT, in basal keratinocytes
González‐Suárez, E., Samper, E., Ramírez, A., Flores, J. M., Martín‐Caballero, J., Jorcano, J. L., & Blasco, M. A. (2001) · The EMBO Journal · doi:10.1093/emboj/20.11.2619 · Cited by 372
The Inflammation Hypothesis of Aging: Molecular Modulation by Calorie Restriction
Chung, H. Y., Kim, H. J., Kim, J. W., & Yu, B. P. (2001) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2001.tb05662.x · Cited by 305
Induction of Keratinocyte Growth Factor Expression Is reduced and Delayed During Wound Healing in the Genetically Diabetic Mouse
Werner, S., Breeden, M. P., Hübner, G., Greenhalgh, D. G., & Longaker, M. T. (1994) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12395564 · Cited by 282
Tissue Inhibitor of Metalloproteinases-1 Is Decreased and Activated Gelatinases Are Increased in Chronic Wounds
Bullen, E. C., Longaker, M. T., Updike, D. L., Benton, R. L., Ladin, D. A., Hou, Z., & Howard, E. W. (1995) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12612786 · Cited by 271
Promotion of wound repair in old mice by local injection of macrophages.
Danon, D., Kowatch, M. A., & Roth, G. S. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.6.2018 · Cited by 252
Aging Is Associated with Reduced Deposition of Specific Extracellular Matrix Components, an Upregulation of Angiogenesis, and an Altered Inflammatory Response in a Murine Incisional Wound Healing Model
Ashcroft, G. S., Horan, M. A., & Ferguson, M. W. J. (1997) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12289705 · Cited by 240
Self-citation
One systemic administration of transforming growth factor-beta 1 reverses age- or glucocorticoid-impaired wound healing.
Beck, L. S., Deguzman, L., Lee, W. P., Xu, Y., Siegel, M., & Amento, E. P. (1993) · Journal of Clinical Investigation · doi:10.1172/jci116904 · Cited by 233
Untitled work
(1998) · PubMed · Cited by 203
Self-citation
Effect of age on wound healing in healthy human beings.
Holt, D. R., Kirk, S., Regan, M., Hurson, M., Lindblad, W. J., & Barbul, A. (1992) · PubMed · Cited by 189
Age-related differences in the temporal and spatial regulation of matrix metalloproteinases (MMPs) in normal skin and acute cutaneous wounds of healthy humans
Ashcroft, G. S., Horan, M. A., Herrick, S. E., Tarnuzzer, R. W., Schultz, G. S., & Ferguson, M. W. J. (1997) · Cell and Tissue Research · doi:10.1007/s004410050963 · Cited by 188
Self-citation
Histologic changes in skin associated with aging
KURBAN, R. S., & BHAWAN, J. (1990) · The Journal of Dermatologic Surgery and Oncology · doi:10.1111/j.1524-4725.1990.tb01554.x · Cited by 187
TGF‐β1 induces the expression of type I collagen and SPARC, and enhances contraction of collagen gels, by fibroblasts from young and aged donors
Reed, M. J., Vernon, R. B., Abrass, I. B., & Sage, E. H. (1994) · Journal of Cellular Physiology · doi:10.1002/jcp.1041580121 · Cited by 177
Structural changes in ageing skin
Montagna, W., & Carlisle, K. S. (1990) · British Journal of Dermatology · doi:10.1111/j.1365-2133.1990.tb16127.x · Cited by 169
Stimulatory Effects of Transforming Growth Factor-beta and Epidermal Growth Factor on Epidermal Cell Outgrowth from Porcine Skin Explant Cultures
Hebda, P. A. (1988) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12476480 · Cited by 157
Up-regulation of elastase in acute wounds of healthy aged humans and chronic venous leg ulcers are associated with matrix degradation.
Herrick, S. E., Ashcroft, G. S., Ireland, G. W., Horan, M. A., McCollum, C. N., & Ferguson, M. W. J. (1997) · PubMed · Cited by 146
Self-citation
Characterization of the Skin In Vivo by High Resolution Magnetic Resonance Imaging: Water Behavior and Age-Related Effects
Richard, S., Querleux, B., Bittoun, J., Jolivet, O., Idy-Peretti, I., de Lacharrière, O., & Lévêque, J. (1993) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12472356 · Cited by 135
Fibroblast senescence in pressure ulcers
Berg, J. S. V., Rudolph, R., Hollan, C., & Haywood‐Reid, P. L. (1998) · Wound Repair and Regeneration · doi:10.1046/j.1524-475x.1998.60107.x · Cited by 133
The proliferative capacity of neonatal skin fibroblasts is reduced after exposure to venous ulcer wound fluid: A potential mechanism for senescence in venous ulcers
Mendez, M. V., Raffetto, J. D., Phillips, T. J., Menzoı́an, J. O., & Park, H. (1999) · Journal of Vascular Surgery · doi:10.1016/s0741-5214(99)70113-8 · Cited by 128
Impaired migration, integrin function, and actin cytoskeletal organization in dermal fibroblasts from a subset of aged human donors
Reed, M. J., Ferara, N. S., & Vernon, R. B. (2001) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(01)00260-3 · Cited by 124
Aging Fibroblasts Present Reduced Epidermal Growth Factor (EGF) Responsiveness Due to Preferential Loss of EGF Receptors
Shiraha, H., Gupta, K. B., Drabik, K., & Wells, A. H. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m000008200 · Cited by 120
Multiple pathways control cell growth and transformation: overlapping and independent activities of p53 and p21Cip1/WAF1/Sdi1
Cox, L. S. (1997) · The Journal of Pathology · doi:10.1002/(sici)1096-9896(199710)183:2 · Cited by 115
The effects of ageing on wound healing: immunolocalisation of growth factors and their receptors in a murine incisional model
Ashcroft, G. S., Horan, M. A., & Ferguson, M. W. J. (1997) · Journal of Anatomy · doi:10.1046/j.1469-7580.1997.19030351.x · Cited by 113
Self-citation
Stereological analysis of collagen and elastic fibers in the normal human dermis: Variability with age, sex, and body region
Vitellaro‐Zuccarello, L., Cappelletti, S., Rossi, V. D. P., & Sari-Gorla, M. (1994) · The Anatomical Record · doi:10.1002/ar.1092380202 · Cited by 105
Differential Activation of Migration by Hypoxia in Keratinocytes Isolated from Donors of Increasing Age: Implication for Chronic Wounds in the Elderly
Xia, Y., Zhao, Y., Tyrone, J. W., Chen, A., & Mustoe, T. A. (2001) · Journal of Investigative Dermatology · doi:10.1046/j.1523-1747.2001.00209.x · Cited by 103
Aging differentially modulates the expression of collagen and collagenase in dermal fibroblasts
Khorramizadeh, M. R., Tredget, E. E., Telasky, C., Shen, Q. “., & Ghahary, A. (1999) · Molecular and Cellular Biochemistry · doi:10.1023/a:1006909021352 · Cited by 102
Similar, but not identical, modulation of expression of extracellular matrix components during in vitro and in vivo aging of human skin fibroblasts
Takeda, K., Gosiewska, A., & Peterkofsky, B. (1992) · Journal of Cellular Physiology · doi:10.1002/jcp.1041530303 · Cited by 99
Growth factor responsiveness declines during adulthood for human skin-derived cells
Stanulis-Praeger, B., & Gilchrest, B. A. (1986) · Mechanisms of Ageing and Development · doi:10.1016/0047-6374(86)90009-6 · Cited by 94
Effect of age and hypoxia on TGFβ1 receptor expression and signal transduction in human dermal fibroblasts: Impact on cell migration
Mogford, J. E., Tawil, N. J., Chen, A., Gies, D., Xia, Y., & Mustoe, T. A. (2002) · Journal of Cellular Physiology · doi:10.1002/jcp.10060 · Cited by 89
Delayed wound healing in aged rats is associated with increased collagen gel remodeling and contraction by skin fibroblasts, not with differences in apoptotic or myofibroblast cell populations
Ballas, C. B., & Davidson, J. M. (2001) · Wound Repair and Regeneration · doi:10.1046/j.1524-475x.2001.00223.x · Cited by 86
Age-related changes in the temporal and spatial distributions of fibrillin and elastin mRNAS and proteins in acute cutaneous wounds of healthy humans
Ashcroft, G. S., Kielty, C. M., Horan, M. A., & Ferguson, M. W. J. (1997) · The Journal of Pathology · doi:10.1002/(sici)1096-9896(199709)183:1 · Cited by 84
Self-citation
Matrix metalloproteinase-9 (92-kd gelatinase/type IV collagenase equals gelatinase B) can degrade arterial elastin.
Katsuda, S., Okada, Y., Okada, Y., Imai, K., & Nakanishi, I. (1994) · PubMed Central · Cited by 83
Determination of the tensile strength of the healing wound as a clinical test.
Sandblom, P., Petersen, P., & MUREN, A. (1953) · PubMed · Cited by 81
Diminished Response of Werner's Syndrome Fibroblasts to Growth Factors PDGF and FGF
Bauer, E. A., Silverman, N., Busiek, D. F., Kronberger, A., & Deuel, T. F. (1986) · Science · doi:10.1126/science.3022382 · Cited by 78
Dehiscence of laparotomy wounds
Halasz, N. A. (1968) · The American Journal of Surgery · doi:10.1016/0002-9610(68)90495-9 · Cited by 76
Wound Repair in Mice as Influenced by Age and Antimacrophage Serum
Cohen, B. J., Danon, D., & Roth, G. S. (1987) · Journal of Gerontology · doi:10.1093/geronj/42.3.295 · Cited by 74
The influence of age on the healing of normal and ischemic incisional skin wounds
Quirinia, A., & Viidik, A. (1991) · Mechanisms of Ageing and Development · doi:10.1016/0047-6374(91)90094-g · Cited by 70
Synthesis of extracellular matrix glycoproteins by cultured microvascular endothelial cells isolated from the dermis of neonatal and adult skin
Kramer, R. H., Fuh, G.-M., Bensch, K. G., & Karasek, M. A. (1985) · Journal of Cellular Physiology · doi:10.1002/jcp.1041230102 · Cited by 69
Longitudinal study of in vivo wound repair and in vitro cellular senescence of dermal fibroblasts
Bruce, S. A., & Deamond, S. F. (1991) · Experimental Gerontology · doi:10.1016/0531-5565(91)90058-t · Cited by 66
Decrease in capillary growth during aging
Yamaura, H., & Matsuzawa, T. (1980) · Experimental Gerontology · doi:10.1016/0531-5565(80)90086-8 · Cited by 62
Aging and Cellular Defense Mechanisms
Giacomoni, P. U. (1992) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1992.tb38642.x · Cited by 59
The effect of passage number on fibroblast cellular senescence in patients with chronic venous insufficiency with and without ulcer
Raffetto, J. D., Mendez, M. V., Phillips, T. J., Park, H., & Menzoı́an, J. O. (1999) · The American Journal of Surgery · doi:10.1016/s0002-9610(99)00134-8 · Cited by 57
Altered cellular responsiveness during ageing
Rattan, S. I. S., & Derventzi, A. (1991) · BioEssays · doi:10.1002/bies.950131111 · Cited by 56
Influence of Aging and Protein Deficiency on Neutrophil Function
Lipschitz, D. A., & Udupa, K. B. (1986) · Journal of Gerontology · doi:10.1093/geronj/41.6.690 · Cited by 55
Effect of Donor Age on Epidermal Growth Factor Processing in Man
Reenstra, W. R., Yaar, M., & Gilchrest, B. A. (1993) · Experimental Cell Research · doi:10.1006/excr.1993.1291 · Cited by 54
Characterization of the subtypes of cell motility in ageing human skin fibroblasts
Pienta, K. J., & Coffey, D. S. (1990) · Mechanisms of Ageing and Development · doi:10.1016/0047-6374(90)90001-v · Cited by 53
Increased Cytokine Production by Peripheral Blood Mononuclear Cells from Healthy Elderly Peoplea
FAGIOLO, U., COSSARIZZA, A., SANTACATERINA, S., ORTOLANI, C., MONTI, D., PAGANELLI, R., & FRANCESCHI, C. (1992) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1992.tb38712.x · Cited by 52
Decline of Fibroblast Chemotaxis with Age of Donor and Cell Passage Number
Albini, A., Pontz, B. F., Pulz, M., Allavena, G., Mensing, H., & Müller, P. K. (1988) · Collagen and Related Research · doi:10.1016/s0174-173x(88)80033-5 · Cited by 46
In vitro characterization of response to stimulus (wounding) with regard to ageing in human skin fibroblasts
Muggleton-Harris, A. L., Reisert, P. S., & Burghoff, R. L. (1982) · Mechanisms of Ageing and Development · doi:10.1016/0047-6374(82)90048-3 · Cited by 42
Strength Development of skin Incisions in young and old Rats
Holm‐Pedersen, P., & Zederfeldt, B. (1971) · Scandinavian Journal of Plastic and Reconstructive Surgery · doi:10.3109/02844317109042930 · Cited by 40
Injury of arterial endothelial cells in diabetic, sucrose-fed and aged rats
ARBOGAST, B., BERRY, D., & Newell, C. L. (1984) · Atherosclerosis · doi:10.1016/0021-9150(84)90142-4 · Cited by 38
Granulocyte Adherence in the Elderly
Silverman, E. M., & Silverman, A. G. (1977) · American Journal of Clinical Pathology · doi:10.1093/ajcp/67.1.49 · Cited by 30
Experimental tumors and aging: local factors that may account for the observed age advantage in the B16 murine melanoma model
Ershler, W. B., Gamelli, R. L., Moore, A. L., Hacker, M. P., & Blow, A. J. (1984) · Experimental Gerontology · doi:10.1016/0531-5565(84)90046-9 · Cited by 29
Fibronectin synthesis and degradation in human fibroblasts with aging
Shevitz, J., Jenkins, C. S. P., & Hatcher, V. B. (1986) · Mechanisms of Ageing and Development · doi:10.1016/0047-6374(86)90125-9 · Cited by 26
Age, gonadectomy, and wound healing in the palatal mucosa of the rat
Butcher, E. O., & Klingsberg, J. (1963) · Oral Surgery Oral Medicine Oral Pathology · doi:10.1016/0030-4220(63)90178-6 · Cited by 23
Interferon and the epidermis: Implications for cellular senescence
Peacocke, M., Yaar, M., & Gilchrest, B. A. (1989) · Experimental Gerontology · doi:10.1016/0531-5565(89)90048-x · Cited by 22
Effects of serum from human subjects of different ages on migration in vitro of human fibroblasts
Kondo, H., Nomaguchi, T. A., & Yonezawa, Y. (1989) · Mechanisms of Ageing and Development · doi:10.1016/0047-6374(89)90004-3 · Cited by 22
Accelerated Wound Repair in Old Deer Mice (peromyscus Maniculatus) and White-footed Mice (peromyscus Leucopus)
Cohen, B. J., Cutler, R. G., & Roth, G. S. (1987) · Journal of Gerontology · doi:10.1093/geronj/42.3.302 · Cited by 22
Tumor necrosis factor reduces lifespan of human endothelial cells in vitro
Shimada, Y., Ito, H., Kaji, K., & Fukuda, M. (1990) · Mechanisms of Ageing and Development · doi:10.1016/0047-6374(90)90152-6 · Cited by 20
Age-related changes in serotonin content and its release reaction of rat platelets
Yonezawa, Y., Kondo, H., & Nomaguchi, T. A. (1989) · Mechanisms of Ageing and Development · doi:10.1016/0047-6374(89)90008-0 · Cited by 18
Effect of aging on macrophage adherence to extracellular matrix proteins
Iiyama, M., Shimada, Y., Kita, T., & Ito, H. (1992) · Mechanisms of Ageing and Development · doi:10.1016/0047-6374(92)90132-w · Cited by 16
Internalization and processing of epidermal growth factor in aging human fibroblasts in culture
Matrisian, L. M., Davis, D. E., & Magun, B. E. (1987) · Experimental Gerontology · doi:10.1016/0531-5565(87)90043-x · Cited by 14
Late passage cells display an increase in contractile behavior
GIBSON, J., Milam, S. B., & Klebe, R. J. (1989) · Mechanisms of Ageing and Development · doi:10.1016/0047-6374(89)90042-0 · Cited by 13
TGF-β and macrophages in the rise and fall of inflammation
McCartney-Francis, N. L., & Wahl, S. M. (2001) · Birkhäuser Basel eBooks · doi:10.1007/978-3-0348-8354-2_4 · Cited by 12
[Effect of in vivo aging on the growth of rat fibroblastic cells from cutaneous explants].
Lombard, N., & Masse, R. S. (1987) · PubMed · Cited by 6

Flagged first, then by citations

Research works printed but not linked: 3

Compton CC (1993) Wound healing potential of cultured epithelium. Wounds Compend Skin Res Pract 5: 97-111
Katsuda S, Okada Y, Okada Y, Imai K and Nakanishi I (1994) matrix metalloproteinase-9 can degrade arterial elastin. Am J Pathol 145: 1208-1218
Pieraggi MJ, Bouissou H, Angelier C, Uhart D, Magnol J and Kokolo J (1985) Le fibroblaste. Ann Path 5: 65-76

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Satellite Cells and the Muscle Stem Cell Niche
Yin, H., Price, F., & Rudnicki, M. A. (2013) · Physiological Reviews · doi:10.1152/physrev.00043.2011 · Cited by 2,166
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Martin, P., & Leibovich, S. J. (2005) · Trends in Cell Biology · doi:10.1016/j.tcb.2005.09.002 · Cited by 1,340
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Authors: Ashcroft, G. S., Mills, S. J., & Ashworth, J. J.
Affiliations: University of Manchester (GB)
Corresponding author: Ashcroft, Gillian S.
ORCID: Mills, Stuart J.
Venue: Biogerontology
Publisher: Springer Science and Business Media LLC
Published: 2002-11
Volume: 3
Issue: 6
Pages: 337-345
ISSN: 1389-5729 (ISSN-L)
1573-6768
DOI: 10.1023/a:1021399228395
OpenAlex: W1530924711
Cited by: 309
References: 78
Citations by year: 2026: 13 · 2025: 20 · 2024: 17 · 2023: 16 · 2022: 14 · 2021: 15 · 2020: 15 · 2019: 19 · 2018: 14 · 2017: 8 · 2016: 8 · 2015: 14 · 2014: 15 · 2013: 11 · 2012: 4
FWCI: 0.96
Type: journal article
Language: en
Open access: closed
Licence: www.springernature.com/gp/researchers/text-and-data-mining (tdm)
www.springernature.com/gp/researchers/text-and-data-mining (vor)
Locations: Biogerontology (publishedVersion)
PubMed (publishedVersion)
Research Explorer (The University of Manchester) (submittedVersion)
Topics: Health Sciences › Medicine › Surgery › Wound Healing and Treatments
Health Sciences › Medicine › Dermatology › Skin Protection and Aging
Health Sciences › Medicine › Dermatology › Dermatologic Treatments and Research
Keywords: aging, skin wound healing, delayed wound healing, older adults, cytokine signaling, chronic inflammation, protein synthesis and degradation, re-epithelialization, scar formation, wound care, cell microenvironment
MeSH terms: Aging, Extracellular Matrix, Humans, Inflammation, Wound Healing, Neovascularization, Physiologic

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