The DOI matches its Crossref record; 78 of the 78 references it cites were found in a registry or an index.
Ageing and wound healing
Abstract
Cutaneous wound healing is a complex process encompassing a number of overlapping events including leukocyte recruitment, matrix deposition, epithelialization, and ultimately resolution of inflammation with the formation of a mature scar. Morbidity associated with age-related delayed wound healing imposes an enormous social and financial burden; unless improved wound care strategies are developed the projected relative and absolute increase in the elderly population will further exacerbate this problem. In recent years insight has been gained into the impact of ageing on cellular and tissue responses, resulting from impaired cytokine signal transduction, unchecked inflammation, an altered balance of protein synthesis and degradation, and subsequent downstream effects on the rate and quality of the wound healing response. Further understanding of the complex interaction between the ageing cell and its microenvironment is essential in order to develop focussed therapeutic strategies to improve healing in the elderly.
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In the citing paper
“In the hemostasis phase, aggregation and degranulation of platelets are enhanced in the elderly [263].”
From Transition from inflammation to proliferation: a critical step during wound healing (2016) · cites this paper as [263]
In the citing paper
“Moreover, the phagocytic activity of wound macrophages in aged mice is decreased compared with young mice, which may account for increased production of proinflammatory cytokines, including IL-1, IL-6, TNF-α, but decreased secretion of VEGF [74, 263, 265].”
From Transition from inflammation to proliferation: a critical step during wound healing (2016) · cites this paper as [263]
Citations
Cites
Longevity, Stress Response, and Cancer in Aging Telomerase-Deficient Mice
Rudolph, K. L., Chang, S., Lee, H.-W., Blasco, M., Gottlieb, G. J., Greider, C., & DePinho, R. A. (1999) · Cell · doi:10.1016/s0092-8674(00)80580-2 · Cited by 1,349 · cited 2×
“In the telomerase null mouse age-dependent telomere shortening and accompanying genetic instability were associated with shortened life span as well as a reduced capacity to respond to stresses such as wound healing ( Rudolph et al. 1999; Gonzalez-Suarez et al. 2001), whereas the epidermis of telomerase-transgenic mic…”
BackgroundTransforming growth factor type beta induces monocyte chemotaxis and growth factor production.
Wahl, S. M., Hunt, D. A., Wakefield, L. M., McCartney-Francis, N. L., Wahl, L. M., Roberts, A. B., & Sporn, M. B. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.16.5788 · Cited by 1,256
Matrix Metalloproteinase-2 Is an Interstitial Collagenase
Aimes, R. T., & Quigley, J. P. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.11.5872 · Cited by 944
Mice lacking Smad3 show accelerated wound healing and an impaired local inflammatory response
Ashcroft, G. S., Yang, X., Glick, A. B., Weinstein, M., Letterio, J. J., Mizel, D. E., Anzano, M., Greenwell-Wild, T., Wahl, S. M., Deng, C., et al. (1999) · Nature Cell Biology · doi:10.1038/12971 · Cited by 911
Self-citationWound Fluid from Chronic Leg Ulcers Contains Elevated Levels of Metalloproteinases MMP-2 and MMP-9
Wysocki, A. B., Staiano-Coico, L., & Grinnell, F. (1993) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12359590 · Cited by 732
Barrandon, Y., & Green, H. (1987) · Cell · doi:10.1016/0092-8674(87)90179-6 · Cited by 693
Estrogen accelerates cutaneous wound healing associated with an increase in TGF-β1 levels
Ashcroft, G. S., Dodsworth, J., Boxtel, E. V., Tarnuzzer, R. W., Horan, M. A., Schultz, G. S., & Ferguson, M. W. J. (1997) · Nature Medicine · doi:10.1038/nm1197-1209 · Cited by 573
Self-citationStructural and functional changes of normal aging skin
Fenske, N. A., & Lober, C. W. (1986) · Journal of the American Academy of Dermatology · doi:10.1016/s0190-9622(86)70208-9 · Cited by 535
Sequential appearance of fibronectin and collagen in experimental granulation tissue.
Kurkinen, M. T., Vaheri, A. I., Roberts, P., & Stenman, S. (1980) · PubMed · Cited by 447
Butcher, S. K., Chahal, H., Nayak, L., Sinclair, A., Henriquez, N. V., Sapey, E., O'Mahony, D., & Lord, J. M. (2001) · Journal of Leukocyte Biology · doi:10.1189/jlb.70.6.881 · Cited by 436
Research works printed but not linked: 3
- Compton CC (1993) Wound healing potential of cultured epithelium. Wounds Compend Skin Res Pract 5: 97-111
- Katsuda S, Okada Y, Okada Y, Imai K and Nakanishi I (1994) matrix metalloproteinase-9 can degrade arterial elastin. Am J Pathol 145: 1208-1218
- Pieraggi MJ, Bouissou H, Angelier C, Uhart D, Magnol J and Kokolo J (1985) Le fibroblaste. Ann Path 5: 65-76
Cited by
Sorted by citations
Inflammation in Wound Repair: Molecular and Cellular Mechanisms
Eming, S. A., Krieg, T., & Davidson, J. M. (2007) · Journal of Investigative Dermatology · doi:10.1038/sj.jid.5700701 · Cited by 2,429
Satellite Cells and the Muscle Stem Cell Niche
Yin, H., Price, F., & Rudnicki, M. A. (2013) · Physiological Reviews · doi:10.1152/physrev.00043.2011 · Cited by 2,166
Transition from inflammation to proliferation: a critical step during wound healing
Landén, N. X., Li, D., & Ståhle, M. (2016) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-016-2268-0 · Cited by 1,980
Inflammatory cells during wound repair: the good, the bad and the ugly
Martin, P., & Leibovich, S. J. (2005) · Trends in Cell Biology · doi:10.1016/j.tcb.2005.09.002 · Cited by 1,340
Inflammation in Chronic Wounds
Zhao, R., Liang, H. H., Clarke, E., Jackson, C., & Xue, M. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17122085 · Cited by 1,250
Metadata
- Authors
- Ashcroft, G. S., Mills, S. J., & Ashworth, J. J.
- Affiliations
- University of Manchester (GB)
- Corresponding author
- Ashcroft, Gillian S.
- ORCID
- Mills, Stuart J.
- Venue
- Biogerontology
- Published
- 2002-11
- Volume
- 3
- Issue
- 6
- Pages
- 337-345
- ISSN
- 1389-5729 (ISSN-L)
- 1573-6768
- OpenAlex
- W1530924711
- Cited by
- 309
- References
- 78
- Citations by year
- 2026: 13 · 2025: 20 · 2024: 17 · 2023: 16 · 2022: 14 · 2021: 15 · 2020: 15 · 2019: 19 · 2018: 14 · 2017: 8 · 2016: 8 · 2015: 14 · 2014: 15 · 2013: 11 · 2012: 4
- FWCI
- 0.96
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Biogerontology (publishedVersion)
- PubMed (publishedVersion)
- Research Explorer (The University of Manchester) (submittedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Wound Healing and Treatments
- Health Sciences › Medicine › Dermatology › Skin Protection and Aging
- Health Sciences › Medicine › Dermatology › Dermatologic Treatments and Research
- Keywords
- aging, skin wound healing, delayed wound healing, older adults, cytokine signaling, chronic inflammation, protein synthesis and degradation, re-epithelialization, scar formation, wound care, cell microenvironment
- MeSH terms
- Aging, Extracellular Matrix, Humans, Inflammation, Wound Healing, Neovascularization, Physiologic
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