Cited by 316Wound Healing and TreatmentsSkin Protection and AgingDermatologic Treatments and Research

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Ageing and wound healing

Ashcroft, Gillian S., Mills, Stuart J., Ashworth, Jason J.·2002·Biogerontology

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Abstract

Cutaneous wound healing is a complex process encompassing a number of overlapping events including leukocyte recruitment, matrix deposition, epithelialization, and ultimately resolution of inflammation with the formation of a mature scar. Morbidity associated with age-related delayed wound healing imposes an enormous social and financial burden; unless improved wound care strategies are developed the projected relative and absolute increase in the elderly population will further exacerbate this problem. In recent years insight has been gained into the impact of ageing on cellular and tissue responses, resulting from impaired cytokine signal transduction, unchecked inflammation, an altered balance of protein synthesis and degradation, and subsequent downstream effects on the rate and quality of the wound healing response. Further understanding of the complex interaction between the ageing cell and its microenvironment is essential in order to develop focussed therapeutic strategies to improve healing in the elderly.

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Authors: Ashcroft, G. S., Mills, S. J., & Ashworth, J. J.
Affiliations: University of Manchester (GB)
Corresponding author: Ashcroft, Gillian S.
ORCID: Mills, Stuart J.
Venue: Biogerontology
Publisher: Springer Science and Business Media LLC
Published: 2002-11
Volume: 3
Issue: 6
Pages: 337-345
ISSN: 1389-5729 (ISSN-L)
1573-6768
DOI: 10.1023/a:1021399228395
OpenAlex: W1530924711
Cited by: 309
References: 78
Citations by year: 2026: 13 · 2025: 20 · 2024: 17 · 2023: 16 · 2022: 14 · 2021: 15 · 2020: 15 · 2019: 19 · 2018: 14 · 2017: 8 · 2016: 8 · 2015: 14 · 2014: 15 · 2013: 11 · 2012: 4
FWCI: 0.96
Type: journal article
Language: en
Open access: closed
Licence: www.springernature.com/gp/researchers/text-and-data-mining (tdm)
www.springernature.com/gp/researchers/text-and-data-mining (vor)
Locations: Biogerontology (publishedVersion)
PubMed (publishedVersion)
Research Explorer (The University of Manchester) (submittedVersion)
Topics: Health Sciences › Medicine › Surgery › Wound Healing and Treatments
Health Sciences › Medicine › Dermatology › Skin Protection and Aging
Health Sciences › Medicine › Dermatology › Dermatologic Treatments and Research
Keywords: aging, skin wound healing, delayed wound healing, older adults, cytokine signaling, chronic inflammation, protein synthesis and degradation, re-epithelialization, scar formation, wound care, cell microenvironment
MeSH terms: Aging, Extracellular Matrix, Humans, Inflammation, Wound Healing, Neovascularization, Physiologic

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