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Cited by 289Head and Neck Cancer StudiesOral Health Pathology and TreatmentEsophageal Cancer Research and Treatment

Combined effect of tobacco and alcohol on laryngeal cancer risk: a case–control study

Talamini, R., Bosetti, C., La Vecchia, C., Dal Maso, L., Levi, F., Bidoli, E., Negri, E., Pasche, C. +3 more·2002·Cancer Causes & Control
DOI 10.1023/a:1021944123914
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Abstract

Objective To provide information on the effects of alcohol and tobacco on laryngeal cancer and its subsites.Methods This was a case-control study conducted between 1992 and 2000 in northern Italy and Switzerland. A total of 527 cases of incident squamous-cell carcinoma of the larynx and 1297 hospital controls frequency-matched with cases on age, sex, and area of residence were included. Odds ratios (ORs) and corresponding 95% confidence intervals (CIs) were estimated using multiple logistic regression.Results In comparison with never smokers, ORs were 19.8 for current smokers and 7.0 for ex-smokers. The risk increased in relation to the number of cigarettes (OR = 42.9 for > or = 25 cigarettes/day) and for duration of smoking (OR = 37.2 for > or = 40 years). For alcohol, the risk increased in relation to number of drinks (OR = 5.9 for > or = 56 drinks per week). Combined alcohol and tobacco consumption showed a multiplicative (OR = 177) rather than an additive risk. For current smokers and current drinkers the risk was higher for supraglottis (ORs 54.9 and 2.6, respectively) than for glottis (ORs 7.4 and 1.8) and others subsites (ORs 10.9 and 1.9).Conclusions Our study shows that both cigarette smoking and alcohol drinking are independent risk factors for laryngeal cancer. Heavy consumption of alcohol and cigarettes determined a multiplicative risk increase, possibly suggesting biological synergy.

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Crossref · 10.1023/a:1021944123914

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  • Alcohol has a strong interaction with tobacco smoking, particularly in terms of its carcinogenic effects on the oral cavity and oesophagus (SCC), acting as a solvent for tobacco carcinogens.

    “Lastly, alcohol also has a strong interaction with tobacco smoking, particularly in terms of its carcinogenic effects on the oral cavity and oesophagus (SCC). Specifically, alcohol acts as a solvent for tobacco carcinogens 157, 158.”

    From The relationship between different dimensions of alcohol use and the burden of disease—an update (2017) · cites this paper as [158]

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Authors
Talamini, R., Bosetti, C., La Vecchia, C., Dal Maso, L., Levi, F., Bidoli, E., Negri, E., Pasche, C., Vaccarella, S., Barzan, L., & Franceschi, S.
Affiliations
  • Centro di Riferimento Oncologico (IT)
  • Mario Negri Institute for Pharmacological Research (IT)
  • Institute of Social and Preventive Medicine (CH)
  • Azienda Ospedaliera Santa Maria Degli Angeli (IT)
  • Centre international de recherche sur le cancer (FR)
Corresponding author
Talamini, R.
ORCID
Venue
Cancer Causes & Control
Publisher
Springer Science and Business Media LLC
Published
2002-12
Volume
13
Issue
10
Pages
957-964
ISSN
  • 0957-5243 (ISSN-L)
  • 1573-7225
DOI
10.1023/a:1021944123914
OpenAlex
W1594464537
Cited by
289
References
42
Citations by year
2026: 4 · 2025: 9 · 2024: 15 · 2023: 13 · 2022: 20 · 2021: 11 · 2020: 18 · 2019: 14 · 2018: 8 · 2017: 8 · 2016: 11 · 2015: 15 · 2014: 16 · 2013: 8 · 2012: 17
FWCI
8.07
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Cancer Causes & Control (publishedVersion)
  • PubMed (publishedVersion)
  • Archivio istituzionale della ricerca (Alma Mater Studiorum Università di Bologna) (submittedVersion)
  • IRIS (submittedVersion)
  • SERVAL (Université de Lausanne) (submittedVersion)
Topics
  • Health Sciences › Medicine › Otorhinolaryngology › Head and Neck Cancer Studies
  • Health Sciences › Dentistry › Periodontics › Oral Health Pathology and Treatment
  • Health Sciences › Medicine › Surgery › Esophageal Cancer Research and Treatment
Keywords
laryngeal cancer, squamous cell carcinoma, smoking, alcohol consumption, synergistic risk
MeSH terms
Adult, Aged, Alcohol Drinking, Carcinoma, Squamous Cell, Female, Humans, Italy, Laryngeal Neoplasms, Male, Middle Aged, Risk Factors, Smoking, Switzerland, Logistic Models, Case-Control Studies

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