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Cited by 91Alcohol Consumption and Health EffectsEsophageal Cancer Research and TreatmentHead and Neck Cancer Studies

Alcohol drinking cessation and its effect on esophageal and head and neck cancers: A pooled analysis

Rehm, Jürgen, Patra, Jayadeep, Popova, Svetlana·2007·International Journal of Cancer
DOI 10.1002/ijc.22798
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Abstract

The objective of this study was to conduct a pooled analysis to evaluate the strength of the evidence available in the epidemiological literature on the association between alcohol drinking cessation and reduction in esophageal and head and neck cancer risks. A search using several electronic bibliographic databases was performed for relevant epidemiological literature between 1966 and 2006. A total of 13 unique studies including over 5,000 cases were found. Categorical and third order polynomial (cubic) regression models were fitted to estimate the temporal relationship between years of drinking cessation and risk of cancer. The risk of esophageal cancer significantly increased within the first 2 yr following cessation [odds ratios (ORs)0–2 yr: 2.50, 95% confidence intervals (CI): 2.23–2.80], then decreased rapidly and significantly after longer periods of abstention (OR 15+ yr: 0.37, 95% CI: 0.33–0.41). An elevated risk, although not strong as for esophageal cancer, was observed for head and neck cancer up to 10 yr of quitting drinking (OR 5–10 yr: 1.26, 95% CI: 1.18–1.35). Such risk only reduced after 10 yr of cessation (OR 10–16 yr: 0.67, 95% CI: 0.63–0.73). After more than 20 yr of alcohol cessation, the risks for both cancers were no longer significantly different from the risk of never drinkers. Our findings demonstrate an important role of alcohol cessation on esophageal and head and neck carcinogenesis. © 2007 Wiley‐Liss, Inc.

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  • Current estimates of the number of cancer cases and cancer deaths caused by alcohol are limited due to the inability to incorporate biological latency which, for many cancer sites, can be 20 years or more.

    “However, current estimates of the number of cancer cases and cancer deaths caused by alcohol are limited due to the inability to incorporate biological latency which, for many cancer sites, can be 20 years or more 185, 186.”

    From The relationship between different dimensions of alcohol use and the burden of disease—an update (2017) · cites this paper as [186]

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Authors
Rehm, J., Patra, J., & Popova, S.
Affiliations
  • University of Toronto (CA)
  • Centre for Addiction and Mental Health (CA)
Corresponding author
Rehm, Jürgen
ORCID
Venue
International Journal of Cancer
Publisher
Wiley
Published
2007-05-08
Volume
121
Issue
5
Pages
1132-1137
ISSN
  • 0020-7136 (ISSN-L)
  • 1097-0215
DOI
10.1002/ijc.22798
OpenAlex
W2163640992
Cited by
91
References
51
Citations by year
2026: 4 · 2025: 3 · 2024: 2 · 2023: 4 · 2022: 3 · 2021: 4 · 2020: 2 · 2019: 4 · 2018: 8 · 2017: 7 · 2016: 7 · 2015: 6 · 2014: 2 · 2013: 8 · 2012: 5
FWCI
3.30
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • International Journal of Cancer (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
  • Health Sciences › Medicine › Surgery › Esophageal Cancer Research and Treatment
  • Health Sciences › Medicine › Otorhinolaryngology › Head and Neck Cancer Studies
Keywords
esophageal cancer, head and neck cancer, alcohol and cancer risk, abstinence duration, cancer risk reduction, carcinogenesis, pooled analysis
MeSH terms
Alcohol Drinking, Esophageal Neoplasms, Head and Neck Neoplasms, Humans, Substance Withdrawal Syndrome, Odds Ratio, Case-Control Studies

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