Principles for Designing Randomized Preventive Trials in Mental Health: An Emerging Developmental Epidemiology Paradigm
Abstract
An emerging population‐based paradigm is now being used to guide the design of preventive trials used to test developmental models. We discuss elements of the designs of several ongoing randomized preventive trials involving reduction of risk for children of divorce, for children who exhibit behavioral or learning problems, and for children whose parents are being treated for depression. To test developmental models using this paradigm, we introduce three classes of design issues: design for prerandomization, design for intervention, and design for postintervention. For each of these areas, we present quantitative results from power calculations. Both scientific and cost implications of these power calculations are discussed in terms of variation among subjects on preintervention measures, unit of intervention, assignment, balancing, number of pretest and posttest measures, and the examination of moderation effects.
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Our classroom blocked design allowed us to test intervention impact on ODRs and suspensions by holding fixed those school contextual effects.
“Our classroom blocked design (i.e., random assignment of children to intervention or control groups from the same classroom) allowed us to test intervention impact on ODRs and suspensions by holding fixed those school contextual effects (Brown and Liao 1999).”
From Intervention to Strengthen Emotional Self-Regulation in Children with Emerging Mental Health Problems: Proximal Impact on School Behavior (2010) · cites this paper as Brown and Liao 1999
This type of classroom blocked design allowed us to hold fixed teacher and classroom context effects in examining impact and is efficient in statistical power.
“This type of classroom blocked design allowed us to hold fixed teacher and classroom context effects in examining impact and is efficient in statistical power (Brown and Liao 1999).”
From Intervention to Strengthen Emotional Self-Regulation in Children with Emerging Mental Health Problems: Proximal Impact on School Behavior (2010) · cites this paper as Brown and Liao 1999
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Self-citation
- Authors
- Brown, C. H., & Liao, J.
- Venue
- American Journal of Community Psychology
- Publisher
- Wiley
- Published
- 1999-10
- Volume
- 27
- Issue
- 5
- Pages
- 673-710
- ISSN
- 0091-0562
- 1573-2770
- Cited by
- 116
- References
- 7
- Language
- en
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