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Cited by 208Neuroscience and Neuropharmacology ResearchNeural dynamics and brain functionMemory and Neural Mechanisms

The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.

Cortical area and species differences in dendritic spine morphology

Benavides-Piccione, Ruth, Ballesteros-Yáñez, Inmaculada, DeFelipe, Javier, Yuste, Rafael·2002·Journal of Neurocytology
DOI 10.1023/a:1024134312173
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Abstract

Dendritic spines receive most excitatory inputs in the neocortex and are morphologically very diverse. Recent evidence has demonstrated linear relationships between the size and length of dendritic spines and important features of its synaptic junction and time constants for calcium compartmentalisation. Therefore, the morphologies of dendritic spines can be directly interpreted functionally. We sought to explore whether there were potential differences in spine morphologies between areas and species that could reflect potential functional differences. For this purpose, we reconstructed and measured thousands of dendritic spines from basal dendrites of layer III pyramidal neurons from mouse temporal and occipital cortex and from human temporal cortex. We find systematic differences in spine densities, spine head size and spine neck length among areas and species. Human spines are systematically larger and longer and exist at higher densities than those in mouse cortex. Also, mouse temporal spines are larger than mouse occipital spines. We do not encounter any correlations between the size of the spine head and its neck length. Our data suggests that the average synaptic input is modulated according to cortical area and differs among species. We discuss the implications of these findings for common algorithms of cortical processing.

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Research works printed but not linked: 5

  1. Feldman, M. L. (1984) Morphology of the neocortical pyramidal neuron. In Cerebral Cortex, Vol. 1, Cellular Components of the Cerebral Cortex (edited by Peters, A. &; Jones, E. G.) pp. 123–200. New York: Plenum Press.
  2. Franklin, K. B. J. &; Paxinos, G. (1997) Themouse brain in stereotaxic coordinates. San Diego: Academic Press.
  3. Lorente de NÓ, R. (1922) La corteza cerebral del ratón. Trabajos Laboratorio Investigaciones Biológicas 20, 41–78.
  4. Lorente de NÓ, R. (1933) Studies on the structure of the cerebral cortex. Journal of Psychology und Neurology 45, 381–438.
  5. RamÓn Y Cajal, S. (1899) La Textura del Sistema Nerviosa del Hombre y los Vertebrados. (Primera Edicion). Madrid: Moya.

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Metadata

Authors
Benavides-Piccione, R., Ballesteros-Yáñez, I., DeFelipe, J., & Yuste, R.
Affiliations
Instituto Cajal (ES)
ORCID
Venue
Journal of Neurocytology
Publisher
Springer Science and Business Media LLC
Published
2002-03
Volume
31
Issue
3-5
Pages
337-346
ISSN
  • 0300-4864 (ISSN-L)
  • 1573-7381
DOI
10.1023/a:1024134312173
OpenAlex
W1482113029
Cited by
207
References
34
Citations by year
2026: 10 · 2025: 8 · 2024: 18 · 2023: 13 · 2022: 11 · 2021: 15 · 2020: 9 · 2019: 8 · 2018: 9 · 2017: 9 · 2016: 8 · 2015: 6 · 2014: 14 · 2013: 5 · 2012: 11
FWCI
1.51
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Journal of Neurocytology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • John Merck Fund
  • Instituo Cajal
  • Ministerio de Ciencia y Tecnología
  • National Eye Institute (R01EY013237, EY 13237)
  • National Institute of Neurological Disorders and Stroke (NS 40726, R01NS040726)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Keywords
dendritic spines, dendritic spine morphology, species differences, layer III pyramidal neurons, basal dendrites, spine density, synaptic input, neocortex
MeSH terms
Adult, Animals, Brain Mapping, Cell Count, Cerebral Cortex, Dendrites, Fluorescent Dyes, Humans, Image Processing, Computer-Assisted, Isoquinolines, Male, Species Specificity, Pyramidal Cells, Cell Size, Mice

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